Atorvastatin treatment of rats with ischemia-reperfusion injury improves adipose-derived mesenchymal stem cell migration and survival via the SDF-1α/CXCR-4 axis

Adipose-derived mesenchymal stem cells (ASCs) transplantation is a promising approach for myocardium repair. Promotion of ASCs migration and survival is the key for improving ASCs efficiency. SDF-1α is a critical factor responsible for ASCs migration and survival. Atorvastatin (Ator) is capable of u...

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Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e79100-e79100
Hauptverfasser:	Cai, Anping, Qiu, Ruofeng, Li, Liwen, Zheng, Dongdan, Dong, Yugang, Yu, Danqing, Huang, Yuli, Rao, Shaoqi, Zhou, Yingling, Mai, Weiyi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - metabolism Adipose Tissue - pathology Allografts Animals Anoxia Apoptosis Atorvastatin Atorvastatin Calcium Bone marrow Cardiology Cardiomyocytes Cardiovascular disease Cell migration Cell Movement - drug effects Cell survival Cell Survival - drug effects Chemokine CXCL12 - metabolism Differentiation Heart attacks Heptanoic Acids - pharmacology Hospitals Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology In vitro methods and tests In vivo methods and tests Injuries Injury analysis Ischemia Male Medical research Mesenchymal Stem Cell Transplantation Mesenchymal stem cells Mesenchymal Stromal Cells - metabolism Mesenchymal Stromal Cells - pathology Mesenchyme Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - therapy Myocardium Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology NG-Nitroarginine methyl ester Nitric oxide Pyrroles - pharmacology Rats Rats, Sprague-Dawley Receptors, CXCR4 - metabolism Reperfusion Rodents Stem cells Survival Transplantation
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