A balanced IL-1β activity is required for host response to Citrobacter rodentium infection

Microbial sensing plays essential roles in the innate immune response to pathogens. In particular, NLRP3 forms a multiprotein inflammasome complex responsible for the maturation of interleukin (IL)-1β. Our aim was to delineate the role of the NLRP3 inflammasome in macrophages, and the contribution o...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2013-12, Vol.8 (12), p.e80656-e80656
Hauptverfasser:	Alipour, Misagh, Lou, Yuefei, Zimmerman, Daniel, Bording-Jorgensen, Michael W, Sergi, Consolato, Liu, Julia J, Wine, Eytan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteria Carrier Proteins - genetics Carrier Proteins - immunology Citrobacter Citrobacter rodentium - immunology Colitis Colonization Crohn's disease Crohns disease Crypts Cytokines Enterobacteriaceae Infections - genetics Enterobacteriaceae Infections - immunology Enterobacteriaceae Infections - pathology Female Homeostasis IL-1β Immune clearance Immune response Immune system Immunity, Innate Infections Infiltration Inflammasomes Inflammasomes - genetics Inflammasomes - immunology Inflammation Inflammatory bowel disease Innate immunity Integrity Interleukin-1beta - genetics Interleukin-1beta - immunology Interleukins Lymph nodes Macrophages Macrophages - immunology Macrophages - pathology Male Medical treatment Mice Mice, Knockout Microorganisms Microscopy NLR Family, Pyrin Domain-Containing 3 Protein Pediatrics Peritoneum Phagocytosis Proteins Rodents
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!