Differences in brain morphological findings between narcolepsy with and without cataplexy
Maps of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) obtained by diffusion tensor imaging (DTI) can detect microscopic axonal changes by estimating the diffusivity of water molecules using magnetic resonance imaging (MRI). We applied an MRI voxel-based statistical approach to...
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| Veröffentlicht in: | PloS one 2013-11, Vol.8 (11), p.e81059-e81059 |
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| creator | Nakamura, Masaki Nishida, Shingo Hayashida, Kenichi Ueki, Yoichiro Dauvilliers, Yves Inoue, Yuichi |
| description | Maps of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) obtained by diffusion tensor imaging (DTI) can detect microscopic axonal changes by estimating the diffusivity of water molecules using magnetic resonance imaging (MRI). We applied an MRI voxel-based statistical approach to FA and ADC maps to evaluate microstructural abnormalities in the brain in narcolepsy and to investigate differences between patients having narcolepsy with and without cataplexy.
Twelve patients with drug-naive narcolepsy with cataplexy (NA/CA), 12 with drug-naive narcolepsy without cataplexy (NA w/o CA) and 12 age-matched healthy normal controls (NC) were enrolled. FA and ADC maps for these 3 groups were statistically compared by using voxel-based one-way ANOVA. In addition, we investigated the correlation between FA and ADC values and clinical variables in the patient groups.
Compared to the NC group, the NA/CA group showed higher ADC values in the left inferior frontal gyrus and left amygdala, and a lower ADC value in the left postcentral gyrus. The ADC value in the right inferior frontal gyrus and FA value in the right precuneus were higher for NA/CA group than for the NA w/o CA group. However, no significant differences were observed in FA and ADC values between the NA w/o CA and NC groups in any of the areas investigated. In addition, no correlation was found between the clinical variables and ADC and FA values of any brain areas in these patient groups.
Several microstructural changes were noted in the inferior frontal gyrus and amygdala in the NA/CA but not in the NA w/o CA group. These findings suggest that these 2 narcolepsy conditions have different pathological mechanisms: narcolepsy without cataplexy form appears to be a potentially broader condition without any significant brain imaging differences from normal controls. |
| doi_str_mv | 10.1371/journal.pone.0081059 |
| format | Article |
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Twelve patients with drug-naive narcolepsy with cataplexy (NA/CA), 12 with drug-naive narcolepsy without cataplexy (NA w/o CA) and 12 age-matched healthy normal controls (NC) were enrolled. FA and ADC maps for these 3 groups were statistically compared by using voxel-based one-way ANOVA. In addition, we investigated the correlation between FA and ADC values and clinical variables in the patient groups.
Compared to the NC group, the NA/CA group showed higher ADC values in the left inferior frontal gyrus and left amygdala, and a lower ADC value in the left postcentral gyrus. The ADC value in the right inferior frontal gyrus and FA value in the right precuneus were higher for NA/CA group than for the NA w/o CA group. However, no significant differences were observed in FA and ADC values between the NA w/o CA and NC groups in any of the areas investigated. In addition, no correlation was found between the clinical variables and ADC and FA values of any brain areas in these patient groups.
Several microstructural changes were noted in the inferior frontal gyrus and amygdala in the NA/CA but not in the NA w/o CA group. These findings suggest that these 2 narcolepsy conditions have different pathological mechanisms: narcolepsy without cataplexy form appears to be a potentially broader condition without any significant brain imaging differences from normal controls.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0081059</identifier><identifier>PMID: 24312261</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abnormalities ; Adult ; Amygdala ; Anisotropy ; Brain ; Brain - pathology ; Brain mapping ; Brain research ; Cataplexy ; Cataplexy - diagnosis ; Cataplexy - etiology ; Cataplexy - pathology ; Change detection ; Correlation ; Cortex (parietal) ; Diagnosis, Differential ; Diffusion ; Diffusion coefficient ; Diffusion Magnetic Resonance Imaging ; Female ; Frontal gyrus ; Humans ; Magnetic resonance ; Magnetic resonance imaging ; Male ; Medical imaging ; Morphology ; Narcolepsy ; Narcolepsy - complications ; Narcolepsy - diagnosis ; Narcolepsy - pathology ; Neuroimaging ; Patients ; Postcentral gyrus ; Sleep disorders ; Studies ; Values ; Variance analysis ; Water chemistry ; Young Adult</subject><ispartof>PloS one, 2013-11, Vol.8 (11), p.e81059-e81059</ispartof><rights>2013 Nakamura, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/3.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Nakamura, et al 2013 Nakamura, et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-bf51c3b2f951b59469fadbfc88c7a61fa967e1142ac0e30d21feb790c9fd2bfd3</citedby><cites>FETCH-LOGICAL-c526t-bf51c3b2f951b59469fadbfc88c7a61fa967e1142ac0e30d21feb790c9fd2bfd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842956/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842956/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24312261$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Arias-Carrion, Oscar</contributor><creatorcontrib>Nakamura, Masaki</creatorcontrib><creatorcontrib>Nishida, Shingo</creatorcontrib><creatorcontrib>Hayashida, Kenichi</creatorcontrib><creatorcontrib>Ueki, Yoichiro</creatorcontrib><creatorcontrib>Dauvilliers, Yves</creatorcontrib><creatorcontrib>Inoue, Yuichi</creatorcontrib><title>Differences in brain morphological findings between narcolepsy with and without cataplexy</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Maps of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) obtained by diffusion tensor imaging (DTI) can detect microscopic axonal changes by estimating the diffusivity of water molecules using magnetic resonance imaging (MRI). We applied an MRI voxel-based statistical approach to FA and ADC maps to evaluate microstructural abnormalities in the brain in narcolepsy and to investigate differences between patients having narcolepsy with and without cataplexy.
Twelve patients with drug-naive narcolepsy with cataplexy (NA/CA), 12 with drug-naive narcolepsy without cataplexy (NA w/o CA) and 12 age-matched healthy normal controls (NC) were enrolled. FA and ADC maps for these 3 groups were statistically compared by using voxel-based one-way ANOVA. In addition, we investigated the correlation between FA and ADC values and clinical variables in the patient groups.
Compared to the NC group, the NA/CA group showed higher ADC values in the left inferior frontal gyrus and left amygdala, and a lower ADC value in the left postcentral gyrus. The ADC value in the right inferior frontal gyrus and FA value in the right precuneus were higher for NA/CA group than for the NA w/o CA group. However, no significant differences were observed in FA and ADC values between the NA w/o CA and NC groups in any of the areas investigated. In addition, no correlation was found between the clinical variables and ADC and FA values of any brain areas in these patient groups.
Several microstructural changes were noted in the inferior frontal gyrus and amygdala in the NA/CA but not in the NA w/o CA group. These findings suggest that these 2 narcolepsy conditions have different pathological mechanisms: narcolepsy without cataplexy form appears to be a potentially broader condition without any significant brain imaging differences from normal controls.</description><subject>Abnormalities</subject><subject>Adult</subject><subject>Amygdala</subject><subject>Anisotropy</subject><subject>Brain</subject><subject>Brain - pathology</subject><subject>Brain mapping</subject><subject>Brain research</subject><subject>Cataplexy</subject><subject>Cataplexy - diagnosis</subject><subject>Cataplexy - etiology</subject><subject>Cataplexy - pathology</subject><subject>Change detection</subject><subject>Correlation</subject><subject>Cortex (parietal)</subject><subject>Diagnosis, Differential</subject><subject>Diffusion</subject><subject>Diffusion coefficient</subject><subject>Diffusion Magnetic Resonance Imaging</subject><subject>Female</subject><subject>Frontal gyrus</subject><subject>Humans</subject><subject>Magnetic resonance</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Morphology</subject><subject>Narcolepsy</subject><subject>Narcolepsy - complications</subject><subject>Narcolepsy - diagnosis</subject><subject>Narcolepsy - pathology</subject><subject>Neuroimaging</subject><subject>Patients</subject><subject>Postcentral gyrus</subject><subject>Sleep disorders</subject><subject>Studies</subject><subject>Values</subject><subject>Variance analysis</subject><subject>Water chemistry</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptUk1v1DAUjBAVLS3_AEEkLr3s4q848QUJlQKVKnGBQ0-WP553vfLawU4o--9Jd9OqRb3YT_bMvDf2VNVbjJaYtvjjJo05qrDsU4QlQh1GjXhRnWBByYITRF8-qo-r16VsEGpox_mr6pgwignh-KS6-eKdgwzRQKl9rHVW07pNuV-nkFbeqFA7H62Pq1JrGG4BYh1VNilAX3b1rR_WtYp2X6RxqI0aVB_g7-6sOnIqFHgz76fVr6-XPy--L65_fLu6-Hy9MA3hw0K7BhuqiRMN1o1gXDhltTNdZ1rFsVOCt4AxI8ogoMgS7EC3AhnhLNHO0tPq_UG3D6nI-VWKxIwT1k7mxYS4OiBsUhvZZ79VeSeT8nJ_kPJKqjx4E0A63ThqsGstp8yQTlhGOou4YIixVpNJ69PcbdRbsAbikFV4Ivr0Jvq1XKU_knaMiIZPAuezQE6_RyiD3PpiIAQVIY37uZuO0-mLJ-iH_6DPu2MHlMmplAzuYRiM5F1S7lnyLilyTspEe_fYyAPpPhr0HwbwvmY</recordid><startdate>20131128</startdate><enddate>20131128</enddate><creator>Nakamura, Masaki</creator><creator>Nishida, Shingo</creator><creator>Hayashida, Kenichi</creator><creator>Ueki, Yoichiro</creator><creator>Dauvilliers, Yves</creator><creator>Inoue, Yuichi</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20131128</creationdate><title>Differences in brain morphological findings between narcolepsy with and without cataplexy</title><author>Nakamura, Masaki ; Nishida, Shingo ; Hayashida, Kenichi ; Ueki, Yoichiro ; Dauvilliers, Yves ; Inoue, Yuichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-bf51c3b2f951b59469fadbfc88c7a61fa967e1142ac0e30d21feb790c9fd2bfd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Abnormalities</topic><topic>Adult</topic><topic>Amygdala</topic><topic>Anisotropy</topic><topic>Brain</topic><topic>Brain - pathology</topic><topic>Brain mapping</topic><topic>Brain research</topic><topic>Cataplexy</topic><topic>Cataplexy - diagnosis</topic><topic>Cataplexy - etiology</topic><topic>Cataplexy - pathology</topic><topic>Change detection</topic><topic>Correlation</topic><topic>Cortex (parietal)</topic><topic>Diagnosis, Differential</topic><topic>Diffusion</topic><topic>Diffusion coefficient</topic><topic>Diffusion Magnetic Resonance Imaging</topic><topic>Female</topic><topic>Frontal gyrus</topic><topic>Humans</topic><topic>Magnetic resonance</topic><topic>Magnetic resonance imaging</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Morphology</topic><topic>Narcolepsy</topic><topic>Narcolepsy - complications</topic><topic>Narcolepsy - diagnosis</topic><topic>Narcolepsy - pathology</topic><topic>Neuroimaging</topic><topic>Patients</topic><topic>Postcentral gyrus</topic><topic>Sleep disorders</topic><topic>Studies</topic><topic>Values</topic><topic>Variance analysis</topic><topic>Water chemistry</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakamura, Masaki</creatorcontrib><creatorcontrib>Nishida, Shingo</creatorcontrib><creatorcontrib>Hayashida, Kenichi</creatorcontrib><creatorcontrib>Ueki, Yoichiro</creatorcontrib><creatorcontrib>Dauvilliers, Yves</creatorcontrib><creatorcontrib>Inoue, Yuichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakamura, Masaki</au><au>Nishida, Shingo</au><au>Hayashida, Kenichi</au><au>Ueki, Yoichiro</au><au>Dauvilliers, Yves</au><au>Inoue, Yuichi</au><au>Arias-Carrion, Oscar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differences in brain morphological findings between narcolepsy with and without cataplexy</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-11-28</date><risdate>2013</risdate><volume>8</volume><issue>11</issue><spage>e81059</spage><epage>e81059</epage><pages>e81059-e81059</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Maps of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) obtained by diffusion tensor imaging (DTI) can detect microscopic axonal changes by estimating the diffusivity of water molecules using magnetic resonance imaging (MRI). We applied an MRI voxel-based statistical approach to FA and ADC maps to evaluate microstructural abnormalities in the brain in narcolepsy and to investigate differences between patients having narcolepsy with and without cataplexy.
Twelve patients with drug-naive narcolepsy with cataplexy (NA/CA), 12 with drug-naive narcolepsy without cataplexy (NA w/o CA) and 12 age-matched healthy normal controls (NC) were enrolled. FA and ADC maps for these 3 groups were statistically compared by using voxel-based one-way ANOVA. In addition, we investigated the correlation between FA and ADC values and clinical variables in the patient groups.
Compared to the NC group, the NA/CA group showed higher ADC values in the left inferior frontal gyrus and left amygdala, and a lower ADC value in the left postcentral gyrus. The ADC value in the right inferior frontal gyrus and FA value in the right precuneus were higher for NA/CA group than for the NA w/o CA group. However, no significant differences were observed in FA and ADC values between the NA w/o CA and NC groups in any of the areas investigated. In addition, no correlation was found between the clinical variables and ADC and FA values of any brain areas in these patient groups.
Several microstructural changes were noted in the inferior frontal gyrus and amygdala in the NA/CA but not in the NA w/o CA group. These findings suggest that these 2 narcolepsy conditions have different pathological mechanisms: narcolepsy without cataplexy form appears to be a potentially broader condition without any significant brain imaging differences from normal controls.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24312261</pmid><doi>10.1371/journal.pone.0081059</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Abnormalities Adult Amygdala Anisotropy Brain Brain - pathology Brain mapping Brain research Cataplexy Cataplexy - diagnosis Cataplexy - etiology Cataplexy - pathology Change detection Correlation Cortex (parietal) Diagnosis, Differential Diffusion Diffusion coefficient Diffusion Magnetic Resonance Imaging Female Frontal gyrus Humans Magnetic resonance Magnetic resonance imaging Male Medical imaging Morphology Narcolepsy Narcolepsy - complications Narcolepsy - diagnosis Narcolepsy - pathology Neuroimaging Patients Postcentral gyrus Sleep disorders Studies Values Variance analysis Water chemistry Young Adult |
| title | Differences in brain morphological findings between narcolepsy with and without cataplexy |
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