Natural stilbenoids isolated from grapevine exhibiting inhibitory effects against HIV-1 integrase and eukaryote MOS1 transposase in vitro activities

Polynucleotidyl transferases are enzymes involved in several DNA mobility mechanisms in prokaryotes and eukaryotes. Some of them such as retroviral integrases are crucial for pathogenous processes and are therefore good candidates for therapeutic approaches. To identify new therapeutic compounds and...

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Veröffentlicht in:	PloS one 2013-11, Vol.8 (11), p.e81184-e81184
Hauptverfasser:	Pflieger, Aude, Waffo Teguo, Pierre, Papastamoulis, Yorgos, Chaignepain, Stéphane, Subra, Frederic, Munir, Soundasse, Delelis, Olivier, Lesbats, Paul, Calmels, Christina, Andreola, Marie-Line, Merillon, Jean-Michel, Auge-Gouillou, Corinne, Parissi, Vincent
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Bark Biological Products - isolation & purification Biological Products - pharmacology Cancer Cell cycle Chemical compounds Chromatography Deoxyribonucleic acid Dimers DNA DNA-Binding Proteins - antagonists & inhibitors Drug Evaluation, Preclinical Enzymes Eukaryota - enzymology Eukaryotes Genomes HEK293 Cells HIV HIV Integrase - metabolism HIV Integrase Inhibitors - isolation & purification HIV Integrase Inhibitors - pharmacology Human immunodeficiency virus Humans Inhibition Integrase Intermediates Lead compounds Lentivirus - drug effects Lentivirus - physiology Life Sciences Medical research Microbiology and Parasitology Mobility Pharmacology Piceatannol Prokaryotes Proteins Resveratrol Stilbenes - isolation & purification Stilbenes - pharmacology Transposase Transposases - antagonists & inhibitors Virus Replication - drug effects Vitis - chemistry
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