A dexamethasone prodrug reduces the renal macrophage response and provides enhanced resolution of established murine lupus nephritis

We evaluated the ability of a macromolecular prodrug of dexamethasone (P-Dex) to treat lupus nephritis in (NZB × NZW)F1 mice. We also explored the mechanism underlying the anti-inflammatory effects of this prodrug. P-Dex eliminated albuminuria in most (NZB × NZW)F1 mice. Furthermore, P-Dex reduced t...

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Veröffentlicht in:	PloS one 2013-11, Vol.8 (11), p.e81483
Hauptverfasser:	Yuan, Fang, Tabor, Dana E, Nelson, Richard K, Yuan, Hongjiang, Zhang, Yijia, Nuxoll, Jenny, Bynoté, Kimberly K, Lele, Subodh M, Wang, Dong, Gould, Karen A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal glands Albuminuria - complications Animals Anti-DNA antibodies Antibodies Antigen-antibody complexes Atrophy Autoimmune diseases Biology Dexamethasone Dexamethasone - metabolism Disease Models, Animal Drug dosages Females Hypertension Hypertension - complications Infiltration Inflammation Inflammatory response Injury prevention Kidney - drug effects Kidney - immunology Kidneys Leukocytes Life span Lupus Lupus nephritis Lupus Nephritis - complications Lupus Nephritis - drug therapy Lupus Nephritis - immunology Macromolecules Macrophages Macrophages - drug effects Macrophages - immunology Mice Nephritis Nephritis, Interstitial - complications Osteoporosis Pharmaceutical sciences Prodrugs - metabolism Prodrugs - pharmacology Prodrugs - therapeutic use Rheumatoid arthritis Rodents Serum levels Splenomegaly - complications Steroids Survival Analysis Time Factors Vasculitis
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