Ubiquitin ligase HUWE1 regulates axon branching through the Wnt/β-catenin pathway in a Drosophila model for intellectual disability

We recently reported that duplication of the E3 ubiquitin ligase HUWE1 results in intellectual disability (ID) in male patients. However, the underlying molecular mechanism remains unknown. We used Drosophila melanogaster as a model to investigate the effect of increased HUWE1 levels on the developi...

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Veröffentlicht in:	PloS one 2013-11, Vol.8 (11), p.e81791-e81791
Hauptverfasser:	Vandewalle, Joke, Langen, Marion, Zschätzsch, Marlen, Zschaetzsch, Marlen, Nijhof, Bonnie, Kramer, Jamie M, Brems, Hilde, Bauters, Marijke, Lauwers, Elsa, Srahna, Mohammed, Marynen, Peter, Verstreken, Patrik, Schenck, Annette, Hassan, Bassem A, Froyen, Guy
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animals Animals, Genetically Modified Axons - metabolism Biology Cell cycle Cognition & reasoning Cognitive ability Courtship Disease Models, Animal Dishevelled protein Drosophila Gene Expression Genes Genetics Genomes Homology Humans Huwe1 protein Insects Intellectual disabilities Intellectual Disability - genetics Intellectual Disability - metabolism Intellectual Disability - physiopathology Laboratories Learning Life sciences Memory mRNA Mushroom Bodies - metabolism Mushroom Bodies - physiopathology Nervous system Neuromuscular Junction - metabolism Neuromuscular junctions Neurons - metabolism Neurotransmission Patients Presynapse Studies Synaptic Transmission Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligases - metabolism Wnt protein Wnt Signaling Pathway β-Catenin
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