Insulin/IGF-I signaling pathways enhances tumor cell invasion through bisecting GlcNAc N-glycans modulation. an interplay with E-cadherin

Changes in glycosylation are considered a hallmark of cancer, and one of the key targets of glycosylation modifications is E-cadherin. We and others have previously demonstrated that E-cadherin has a role in the regulation of bisecting GlcNAc N-glycans expression, remaining to be determined the E-ca...

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Veröffentlicht in:	PloS one 2013-11, Vol.8 (11), p.e81579-e81579
Hauptverfasser:	de-Freitas-Junior, Julio Cesar Madureira, Carvalho, Sandra, Dias, Ana M, Oliveira, Patrícia, Cabral, Joana, Seruca, Raquel, Oliveira, Carla, Morgado-Díaz, José Andrés, Reis, Celso A, Pinho, Salomé S
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylglucosamine - metabolism beta Catenin - metabolism Blotting, Western Cadherins - metabolism Cancer Cell adhesion & migration Cell Line, Tumor Cellular biology Cytoplasm - metabolism E-cadherin Extracellular signal-regulated kinase Fluorescent Antibody Technique Gene expression Genotype & phenotype Glycosylation Humans Immunoglobulins Immunology Impact analysis Insulin Insulin - metabolism Insulin-like growth factor I Insulin-Like Growth Factor I - metabolism Insulin-like growth factors Kinases Localization Mesenchyme Metastasis Modulation N-glycans Neoplasm Invasiveness Networking Pathology Phosphorylation Polysaccharides Polysaccharides - metabolism Real-Time Polymerase Chain Reaction Signal Transduction Signaling Tyrosine
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