CD4+NKG2D+ T cells exhibit enhanced migratory and encephalitogenic properties in neuroinflammation

Migration of encephalitogenic CD4(+) T lymphocytes across the blood-brain barrier is an essential step in the pathogenesis of multiple sclerosis (MS). We here demonstrate that expression of the co-stimulatory receptor NKG2D defines a subpopulation of CD4(+) T cells with elevated levels of markers fo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2013-11, Vol.8 (11), p.e81455-e81455
Hauptverfasser:	Ruck, Tobias, Bittner, Stefan, Gross, Catharina C, Breuer, Johanna, Albrecht, Stefanie, Korr, Sabrina, Göbel, Kerstin, Pankratz, Susann, Henschel, Christian M, Schwab, Nicholas, Staszewski, Ori, Prinz, Marco, Kuhlmann, Tanja, Meuth, Sven G, Wiendl, Heinz
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood-Brain Barrier CD4 antigen CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - immunology Cell activation Cell adhesion & migration Central nervous system Cerebrospinal fluid Chemotaxis, Leukocyte Cytokines Cytotoxicity Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - metabolism Encephalomyelitis, Autoimmune, Experimental - pathology Endothelial cells Experimental allergic encephalomyelitis Helper cells Humans Inflammation Interferon Interleukin 17 Kinases Lesions Leukocyte migration Ligands Lymphocytes Lymphocytes T Multiple sclerosis Multiple Sclerosis - immunology Multiple Sclerosis - pathology Nervous system Neurology Neuropathology NK Cell Lectin-Like Receptor Subfamily K - immunology NK Cell Lectin-Like Receptor Subfamily K - metabolism Oligodendrocytes Pathogenesis Patients Proteins Rodents Signal Transduction T cell receptors γ-Interferon
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!