The role of TLR4 896 A>G and 1196 C>T in susceptibility to infections: a review and meta-analysis of genetic association studies
Toll-like receptor 4 plays a role in pathogen recognition, and common polymorphisms may alter host susceptibility to infectious diseases. To review the association of two common polymorphisms (TLR4 896A>G and TLR4 1196C>T) with infectious diseases. We searched PubMed and EMBASE up to March 201...
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| creator | Ziakas, Panayiotis D Prodromou, Michael L El Khoury, Joseph Zintzaras, Elias Mylonakis, Eleftherios |
| description | Toll-like receptor 4 plays a role in pathogen recognition, and common polymorphisms may alter host susceptibility to infectious diseases.
To review the association of two common polymorphisms (TLR4 896A>G and TLR4 1196C>T) with infectious diseases.
We searched PubMed and EMBASE up to March 2013 for pertinent literature in English, and complemented search with references lists of eligible studies.
We included all studies that: reported an infectious outcome; had a case-control design and reported the TLR4 896A>G and/or TLR4 1196C>T genotype frequencies; 59 studies fulfilled these criteria and were analyzed.
Two authors independently extracted study data.
The generalized odds ratio metric (ORG) was used to quantify the impact of TLR4 variants on disease susceptibility. A meta-analysis was undertaken for outcomes reported in >1 study. Eleven of 37 distinct outcomes were significant. TLR4 896 A>G increased risk for all parasitic infections (ORG 1.59; 95%CI 1.05-2.42), malaria (1.31; 95%CI 1.04-1.66), brucellosis (2.66; 95%CI 1.66-4.27), cutaneous leishmaniasis (7.22; 95%CI 1.91-27.29), neurocysticercosis (4.39; 95%CI 2.53-7.61), Streptococcus pyogenes tonsillar disease (2.93; 95%CI 1.24-6.93) , typhoid fever (2.51; 95%CI 1.18-5.34) and adult urinary tract infections (1.98; 95%CI 1.04-3.98), but was protective for leprosy (0.36; 95%CI 0.22-0.60). TLR4 1196 C>T effects were similar to TLR4 896 A>G for brucellosis, cutaneous leishmaniasis, leprosy, typhoid fever and S. pyogenes tonsillar disease, and was protective for bacterial vaginosis in pregnancy (0.55; 95%CI 0.31-0.98) and Haemophilus influenzae tonsillar disease (0.42; 95%CI 0.17-1.00). The majority of significant associations were among predominantly Asian populations and significant associations were rare among European populations.
Depending on the type of infection and population, TLR4 polymorphisms are associated with increased, decreased or no difference in infectious disease. This may be due to differential functional expression of TLR4, the co-segregation of TLR4 variants or a favorable inflammatory response. |
| doi_str_mv | 10.1371/journal.pone.0081047 |
| format | Article |
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To review the association of two common polymorphisms (TLR4 896A>G and TLR4 1196C>T) with infectious diseases.
We searched PubMed and EMBASE up to March 2013 for pertinent literature in English, and complemented search with references lists of eligible studies.
We included all studies that: reported an infectious outcome; had a case-control design and reported the TLR4 896A>G and/or TLR4 1196C>T genotype frequencies; 59 studies fulfilled these criteria and were analyzed.
Two authors independently extracted study data.
The generalized odds ratio metric (ORG) was used to quantify the impact of TLR4 variants on disease susceptibility. A meta-analysis was undertaken for outcomes reported in >1 study. Eleven of 37 distinct outcomes were significant. TLR4 896 A>G increased risk for all parasitic infections (ORG 1.59; 95%CI 1.05-2.42), malaria (1.31; 95%CI 1.04-1.66), brucellosis (2.66; 95%CI 1.66-4.27), cutaneous leishmaniasis (7.22; 95%CI 1.91-27.29), neurocysticercosis (4.39; 95%CI 2.53-7.61), Streptococcus pyogenes tonsillar disease (2.93; 95%CI 1.24-6.93) , typhoid fever (2.51; 95%CI 1.18-5.34) and adult urinary tract infections (1.98; 95%CI 1.04-3.98), but was protective for leprosy (0.36; 95%CI 0.22-0.60). TLR4 1196 C>T effects were similar to TLR4 896 A>G for brucellosis, cutaneous leishmaniasis, leprosy, typhoid fever and S. pyogenes tonsillar disease, and was protective for bacterial vaginosis in pregnancy (0.55; 95%CI 0.31-0.98) and Haemophilus influenzae tonsillar disease (0.42; 95%CI 0.17-1.00). The majority of significant associations were among predominantly Asian populations and significant associations were rare among European populations.
Depending on the type of infection and population, TLR4 polymorphisms are associated with increased, decreased or no difference in infectious disease. This may be due to differential functional expression of TLR4, the co-segregation of TLR4 variants or a favorable inflammatory response.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0081047</identifier><identifier>PMID: 24282567</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Bacteria ; Brucellosis ; Cutaneous leishmaniasis ; Cysticercosis ; Data processing ; Fever ; Genes ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Gum disease ; Health risks ; Hospitals ; Humans ; Immunology ; Infection - genetics ; Infections ; Infectious diseases ; Inflammation ; Inflammatory response ; Leprosy ; Lists ; Malaria ; Medical schools ; Meta-analysis ; Mutation ; Parasitic diseases ; Polymorphism, Genetic ; Populations ; Porphyromonas gingivalis ; Pregnancy ; Proteins ; Streptococcus infections ; Studies ; TLR4 protein ; Toll-Like Receptor 4 - genetics ; Toll-like receptors ; Tonsil ; Tuberculosis ; Typhoid ; Urinary tract ; Vaginosis ; Vector-borne diseases ; Waterborne diseases</subject><ispartof>PloS one, 2013-11, Vol.8 (11), p.e81047-e81047</ispartof><rights>2013 Ziakas et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/3.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Ziakas et al 2013 Ziakas et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4417-2cf307ab1bbda2b481694cab776307e4b241c4d1fe4419eb773cf78d722ad9da3</citedby><cites>FETCH-LOGICAL-c4417-2cf307ab1bbda2b481694cab776307e4b241c4d1fe4419eb773cf78d722ad9da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840016/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840016/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,2098,2917,23849,27907,27908,53774,53776,79351,79352</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24282567$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Norata, Giuseppe Danilo</contributor><creatorcontrib>Ziakas, Panayiotis D</creatorcontrib><creatorcontrib>Prodromou, Michael L</creatorcontrib><creatorcontrib>El Khoury, Joseph</creatorcontrib><creatorcontrib>Zintzaras, Elias</creatorcontrib><creatorcontrib>Mylonakis, Eleftherios</creatorcontrib><title>The role of TLR4 896 A>G and 1196 C>T in susceptibility to infections: a review and meta-analysis of genetic association studies</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Toll-like receptor 4 plays a role in pathogen recognition, and common polymorphisms may alter host susceptibility to infectious diseases.
To review the association of two common polymorphisms (TLR4 896A>G and TLR4 1196C>T) with infectious diseases.
We searched PubMed and EMBASE up to March 2013 for pertinent literature in English, and complemented search with references lists of eligible studies.
We included all studies that: reported an infectious outcome; had a case-control design and reported the TLR4 896A>G and/or TLR4 1196C>T genotype frequencies; 59 studies fulfilled these criteria and were analyzed.
Two authors independently extracted study data.
The generalized odds ratio metric (ORG) was used to quantify the impact of TLR4 variants on disease susceptibility. A meta-analysis was undertaken for outcomes reported in >1 study. Eleven of 37 distinct outcomes were significant. TLR4 896 A>G increased risk for all parasitic infections (ORG 1.59; 95%CI 1.05-2.42), malaria (1.31; 95%CI 1.04-1.66), brucellosis (2.66; 95%CI 1.66-4.27), cutaneous leishmaniasis (7.22; 95%CI 1.91-27.29), neurocysticercosis (4.39; 95%CI 2.53-7.61), Streptococcus pyogenes tonsillar disease (2.93; 95%CI 1.24-6.93) , typhoid fever (2.51; 95%CI 1.18-5.34) and adult urinary tract infections (1.98; 95%CI 1.04-3.98), but was protective for leprosy (0.36; 95%CI 0.22-0.60). TLR4 1196 C>T effects were similar to TLR4 896 A>G for brucellosis, cutaneous leishmaniasis, leprosy, typhoid fever and S. pyogenes tonsillar disease, and was protective for bacterial vaginosis in pregnancy (0.55; 95%CI 0.31-0.98) and Haemophilus influenzae tonsillar disease (0.42; 95%CI 0.17-1.00). The majority of significant associations were among predominantly Asian populations and significant associations were rare among European populations.
Depending on the type of infection and population, TLR4 polymorphisms are associated with increased, decreased or no difference in infectious disease. This may be due to differential functional expression of TLR4, the co-segregation of TLR4 variants or a favorable inflammatory response.</description><subject>Bacteria</subject><subject>Brucellosis</subject><subject>Cutaneous leishmaniasis</subject><subject>Cysticercosis</subject><subject>Data processing</subject><subject>Fever</subject><subject>Genes</subject><subject>Genetic Predisposition to Disease</subject><subject>Genome-Wide Association Study</subject><subject>Gum disease</subject><subject>Health risks</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunology</subject><subject>Infection - genetics</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Inflammation</subject><subject>Inflammatory response</subject><subject>Leprosy</subject><subject>Lists</subject><subject>Malaria</subject><subject>Medical schools</subject><subject>Meta-analysis</subject><subject>Mutation</subject><subject>Parasitic diseases</subject><subject>Polymorphism, Genetic</subject><subject>Populations</subject><subject>Porphyromonas gingivalis</subject><subject>Pregnancy</subject><subject>Proteins</subject><subject>Streptococcus infections</subject><subject>Studies</subject><subject>TLR4 protein</subject><subject>Toll-Like Receptor 4 - genetics</subject><subject>Toll-like receptors</subject><subject>Tonsil</subject><subject>Tuberculosis</subject><subject>Typhoid</subject><subject>Urinary tract</subject><subject>Vaginosis</subject><subject>Vector-borne diseases</subject><subject>Waterborne diseases</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptUstuEzEUHSEQLYU_QGCJTTcTfG1nPMMiUhWVUikSEgpry487qaPJONgzRdnx6TiPVi1iZfv4nHMfOkXxHugEuITP6zDGXneTbehxQmkNVMgXxTk0nJUVo_zlk_tZ8SalNaVTXlfV6-KMCVazaSXPiz_LOyQxdEhCS5aLH4LUTUWuZjdE944A5Md8tiS-J2lMFreDN77zw44MIYMt2sGHPn0hmkS89_j7INvgoEudm9sln_bGK-xx8JbolIL1eq8haRidx_S2eNXqLuG703lR_Px6vZx_Kxffb27nV4vSCgGyZLblVGoDxjjNjKihaoTVRsoq4ygME2CFgxYzvcGMc9vK2knGtGuc5hfFx6PvtgtJnZaXFIgKJDQCeGbcHhku6LXaRr_RcaeC9uoAhLhSOuYpOlSVtDAFagy3IGgt66ml2DhjrTRauiZ7zU7VRrNBZ7Efou6emT7_6f2dWoV7xWtBKVTZ4PJkEMOvEdOgNj7vv-t0j2E89M1yCuopZOqnf6j_n04cWTaGlCK2j80AVftAPajUPlDqFKgs-_B0kEfRQ4L4X2TMyFc</recordid><startdate>20131125</startdate><enddate>20131125</enddate><creator>Ziakas, Panayiotis D</creator><creator>Prodromou, Michael L</creator><creator>El Khoury, Joseph</creator><creator>Zintzaras, Elias</creator><creator>Mylonakis, Eleftherios</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20131125</creationdate><title>The role of TLR4 896 A>G and 1196 C>T in susceptibility to infections: a review and meta-analysis of genetic association studies</title><author>Ziakas, Panayiotis D ; Prodromou, Michael L ; El Khoury, Joseph ; Zintzaras, Elias ; Mylonakis, Eleftherios</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4417-2cf307ab1bbda2b481694cab776307e4b241c4d1fe4419eb773cf78d722ad9da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Bacteria</topic><topic>Brucellosis</topic><topic>Cutaneous leishmaniasis</topic><topic>Cysticercosis</topic><topic>Data processing</topic><topic>Fever</topic><topic>Genes</topic><topic>Genetic Predisposition to Disease</topic><topic>Genome-Wide Association Study</topic><topic>Gum disease</topic><topic>Health risks</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Immunology</topic><topic>Infection - genetics</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Inflammation</topic><topic>Inflammatory response</topic><topic>Leprosy</topic><topic>Lists</topic><topic>Malaria</topic><topic>Medical schools</topic><topic>Meta-analysis</topic><topic>Mutation</topic><topic>Parasitic diseases</topic><topic>Polymorphism, Genetic</topic><topic>Populations</topic><topic>Porphyromonas gingivalis</topic><topic>Pregnancy</topic><topic>Proteins</topic><topic>Streptococcus infections</topic><topic>Studies</topic><topic>TLR4 protein</topic><topic>Toll-Like Receptor 4 - genetics</topic><topic>Toll-like receptors</topic><topic>Tonsil</topic><topic>Tuberculosis</topic><topic>Typhoid</topic><topic>Urinary tract</topic><topic>Vaginosis</topic><topic>Vector-borne diseases</topic><topic>Waterborne diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ziakas, Panayiotis D</creatorcontrib><creatorcontrib>Prodromou, Michael L</creatorcontrib><creatorcontrib>El Khoury, Joseph</creatorcontrib><creatorcontrib>Zintzaras, Elias</creatorcontrib><creatorcontrib>Mylonakis, Eleftherios</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ziakas, Panayiotis D</au><au>Prodromou, Michael L</au><au>El Khoury, Joseph</au><au>Zintzaras, Elias</au><au>Mylonakis, Eleftherios</au><au>Norata, Giuseppe Danilo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of TLR4 896 A>G and 1196 C>T in susceptibility to infections: a review and meta-analysis of genetic association studies</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-11-25</date><risdate>2013</risdate><volume>8</volume><issue>11</issue><spage>e81047</spage><epage>e81047</epage><pages>e81047-e81047</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Toll-like receptor 4 plays a role in pathogen recognition, and common polymorphisms may alter host susceptibility to infectious diseases.
To review the association of two common polymorphisms (TLR4 896A>G and TLR4 1196C>T) with infectious diseases.
We searched PubMed and EMBASE up to March 2013 for pertinent literature in English, and complemented search with references lists of eligible studies.
We included all studies that: reported an infectious outcome; had a case-control design and reported the TLR4 896A>G and/or TLR4 1196C>T genotype frequencies; 59 studies fulfilled these criteria and were analyzed.
Two authors independently extracted study data.
The generalized odds ratio metric (ORG) was used to quantify the impact of TLR4 variants on disease susceptibility. A meta-analysis was undertaken for outcomes reported in >1 study. Eleven of 37 distinct outcomes were significant. TLR4 896 A>G increased risk for all parasitic infections (ORG 1.59; 95%CI 1.05-2.42), malaria (1.31; 95%CI 1.04-1.66), brucellosis (2.66; 95%CI 1.66-4.27), cutaneous leishmaniasis (7.22; 95%CI 1.91-27.29), neurocysticercosis (4.39; 95%CI 2.53-7.61), Streptococcus pyogenes tonsillar disease (2.93; 95%CI 1.24-6.93) , typhoid fever (2.51; 95%CI 1.18-5.34) and adult urinary tract infections (1.98; 95%CI 1.04-3.98), but was protective for leprosy (0.36; 95%CI 0.22-0.60). TLR4 1196 C>T effects were similar to TLR4 896 A>G for brucellosis, cutaneous leishmaniasis, leprosy, typhoid fever and S. pyogenes tonsillar disease, and was protective for bacterial vaginosis in pregnancy (0.55; 95%CI 0.31-0.98) and Haemophilus influenzae tonsillar disease (0.42; 95%CI 0.17-1.00). The majority of significant associations were among predominantly Asian populations and significant associations were rare among European populations.
Depending on the type of infection and population, TLR4 polymorphisms are associated with increased, decreased or no difference in infectious disease. This may be due to differential functional expression of TLR4, the co-segregation of TLR4 variants or a favorable inflammatory response.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24282567</pmid><doi>10.1371/journal.pone.0081047</doi><oa>free_for_read</oa></addata></record> |
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| language | eng |
| recordid | cdi_plos_journals_1461719413 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Bacteria Brucellosis Cutaneous leishmaniasis Cysticercosis Data processing Fever Genes Genetic Predisposition to Disease Genome-Wide Association Study Gum disease Health risks Hospitals Humans Immunology Infection - genetics Infections Infectious diseases Inflammation Inflammatory response Leprosy Lists Malaria Medical schools Meta-analysis Mutation Parasitic diseases Polymorphism, Genetic Populations Porphyromonas gingivalis Pregnancy Proteins Streptococcus infections Studies TLR4 protein Toll-Like Receptor 4 - genetics Toll-like receptors Tonsil Tuberculosis Typhoid Urinary tract Vaginosis Vector-borne diseases Waterborne diseases |
| title | The role of TLR4 896 A>G and 1196 C>T in susceptibility to infections: a review and meta-analysis of genetic association studies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T00%3A18%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20role%20of%20TLR4%20896%20A%3EG%20and%201196%20C%3ET%20in%20susceptibility%20to%20infections:%20a%20review%20and%20meta-analysis%20of%20genetic%20association%20studies&rft.jtitle=PloS%20one&rft.au=Ziakas,%20Panayiotis%20D&rft.date=2013-11-25&rft.volume=8&rft.issue=11&rft.spage=e81047&rft.epage=e81047&rft.pages=e81047-e81047&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0081047&rft_dat=%3Cproquest_plos_%3E3137376031%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1461719413&rft_id=info:pmid/24282567&rft_doaj_id=oai_doaj_org_article_67c1510bb3c1408785c0e9dbcc7ba7d9&rfr_iscdi=true |