λ Phage nanobioparticle expressing apoptin efficiently suppress human breast carcinoma tumor growth in vivo

Using phages is a novel field of cancer therapy and phage nanobioparticles (NBPs) such as λ phage could be modified to deliver and express genetic cassettes into eukaryotic cells safely in contrast with animal viruses. Apoptin, a protein from chicken anemia virus (CAV) has the ability to specificall...

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Veröffentlicht in:	PloS one 2013-11, Vol.8 (11), p.e79907
Hauptverfasser:	Shoae-Hassani, Alireza, Keyhanvar, Peyman, Seifalian, Alexander Marcus, Mortazavi-Tabatabaei, Seyed Abdolreza, Ghaderi, Narmin, Issazadeh, Khosro, Amirmozafari, Nour, Verdi, Javad
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia Animals Antineoplastic Agents Apoptosis Bacteriophage lambda - genetics Biotechnology Breast Breast cancer Breast carcinoma Breast Neoplasms - pathology Cancer Cancer therapies Capsid Proteins - genetics Cassettes Cell Division - genetics ErbB-2 protein Female Flow Cytometry Fluorescence Humans Iodides Kinases Mice Mice, Nude Nanoparticles Phages Propidium iodide Recombinant Proteins - genetics Science Surgical implants Therapy Transfection Tumor cell lines Viruses
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