TGF-β Regulates Enamel Mineralization and Maturation through KLK4 Expression

Transforming growth factor-β (TGF-β) signaling plays an important role in regulating crucial biological processes such as cell proliferation, differentiation, apoptosis, and extracellular matrix remodeling. Many of these processes are also an integral part of amelogenesis. In order to delineate a pr...

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Veröffentlicht in:	PloS one 2013-11, Vol.8 (11), p.e82267
Hauptverfasser:	Cho, Andrew, Haruyama, Naoto, Hall, Bradford, Danton, Mary Jo S, Zhang, Lu, Arany, Praveen, Mooney, David J, Harichane, Yassine, Goldberg, Michel, Gibson, Carolyn W, Kulkarni, Ashok B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adapter proteins AMBN protein Amelogenin Apoptosis Biological activity Cell proliferation Cre recombinase Crystallites Crystals Defects Dental enamel Dental schools Deoxyribonucleic acid Developmental biology DNA Enamel Enamelin Extracellular matrix Gene expression Genomics Growth factors Laboratory animals Localization Maturation Mice Mineralization mRNA Potassium Signal transduction Signaling Teeth Transforming growth factor-b Transgenic mice
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