Torsadogenic risk of antipsychotics: combining adverse event reports with drug utilization data across Europe

Antipsychotics (APs) have been associated with risk of torsade de Pointes (TdP). This has important public health implications. Therefore, (a) we exploited the public FDA Adverse Event Reporting System (FAERS) to characterize their torsadogenic profile; (b) we collected drug utilization data from 12...

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Veröffentlicht in:	PloS one 2013-11, Vol.8 (11), p.e81208
Hauptverfasser:	Raschi, Emanuel, Poluzzi, Elisabetta, Godman, Brian, Koci, Ariola, Moretti, Ugo, Kalaba, Marija, Bennie, Marion, Barbui, Corrado, Wettermark, Bjorn, Sturkenboom, Miriam, De Ponti, Fabrizio
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Adverse Drug Reaction Reporting Systems Antipsychotic Agents - adverse effects Antipsychotic Agents - therapeutic use Antipsychotics Arrhythmia Chlorpromazine Clozapine Complications and side effects Confidence intervals Criteria Data processing Drug Utilization Drugs Europe Exposure Fluphenazine Haloperidol Heart Heart diseases Humans Inhabitants Metabolism Olanzapine Pharmacology Pharmacovigilance Pharmacy Prescription drugs Psychiatrists Psychotropic drugs Public health Quetiapine Risk Risperidone Signal strength Studies Torsades de Pointes - chemically induced Torsades de Pointes - epidemiology Trends United States United States Food and Drug Administration Utilization Ventricle Ziprasidone
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