c-MET regulates myoblast motility and myocyte fusion during adult skeletal muscle regeneration

Adult muscle stem cells, satellite cells (SCs), endow skeletal muscle with tremendous regenerative capacity. Upon injury, SCs activate, proliferate, and migrate as myoblasts to the injury site where they become myocytes that fuse to form new muscle. How migration is regulated, though, remains largel...

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Veröffentlicht in:	PloS one 2013-11, Vol.8 (11), p.e81757-e81757
Hauptverfasser:	Webster, Micah T, Fan, Chen-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Stem Cells - cytology Adult Stem Cells - metabolism Animals c-Met protein Cell adhesion & migration Cell Differentiation Cell Fusion Cell migration Cell Movement Cells (biology) Cytoskeleton Cytoskeleton - chemistry Cytoskeleton - metabolism Defects Embryo, Mammalian Embryogenesis Embryology Embryonic development Embryonic Development - genetics Embryonic growth stage Female Gene Expression Growth factors Injuries Kinases Lamellipodia Male Mice Mice, Transgenic Muscle Cells - cytology Muscle Cells - metabolism Muscle, Skeletal - injuries Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscles Musculoskeletal system Mutation Myoblasts Myoblasts, Skeletal - cytology Myoblasts, Skeletal - metabolism Myocytes Nitric oxide Phosphorylation Protein-tyrosine kinase receptors Proteins Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - metabolism Pseudopodia Pseudopodia - metabolism Regeneration Regeneration - genetics Rodents Satellite cells Skeletal muscle Stem cell transplantation Stem cells Tyrosine
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