Impact of acute changes of left ventricular contractility on the transvalvular impedance: validation study by pressure-volume loop analysis in healthy pigs
The real-time and continuous assessment of left ventricular (LV) myocardial contractility through an implanted device is a clinically relevant goal. Transvalvular impedance (TVI) is an impedentiometric signal detected in the right cardiac chambers that changes during stroke volume fluctuations in pa...
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| creator | Lionetti, Vincenzo Romano, Simone Lorenzo Bianchi, Giacomo Bernini, Fabio Dushpanova, Anar Mascia, Giuseppe Nesti, Martina Di Gregorio, Franco Barbetta, Alberto Padeletti, Luigi |
| description | The real-time and continuous assessment of left ventricular (LV) myocardial contractility through an implanted device is a clinically relevant goal. Transvalvular impedance (TVI) is an impedentiometric signal detected in the right cardiac chambers that changes during stroke volume fluctuations in patients. However, the relationship between TVI signals and LV contractility has not been proven. We investigated whether TVI signals predict changes of LV inotropic state during clinically relevant loading and inotropic conditions in swine normal heart.
The assessment of RVTVI signals was performed in anesthetized adult healthy anesthetized pigs (n = 6) instrumented for measurement of aortic and LV pressure, dP/dtmax and LV volumes. Myocardial contractility was assessed with the slope (Ees) of the LV end systolic pressure-volume relationship. Effective arterial elastance (Ea) and stroke work (SW) were determined from the LV pressure-volume loops. Pigs were studied at rest (baseline), after transient mechanical preload reduction and afterload increase, after 10-min of low dose dobutamine infusion (LDDS, 10 ug/kg/min, i.v), and esmolol administration (ESMO, bolus of 500 µg and continuous infusion of 100 µg·kg-1·min-1).
We detected a significant relationship between ESTVI and dP/dtmax during LDDS and ESMO administration. In addition, the fluctuations of ESTVI were significantly related to changes of the Ees during afterload increase, LDDS and ESMO infusion.
ESTVI signal detected in right cardiac chamber is significantly affected by acute changes in cardiac mechanical activity and is able to predict acute changes of LV inotropic state in normal heart. |
| doi_str_mv | 10.1371/journal.pone.0080591 |
| format | Article |
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The assessment of RVTVI signals was performed in anesthetized adult healthy anesthetized pigs (n = 6) instrumented for measurement of aortic and LV pressure, dP/dtmax and LV volumes. Myocardial contractility was assessed with the slope (Ees) of the LV end systolic pressure-volume relationship. Effective arterial elastance (Ea) and stroke work (SW) were determined from the LV pressure-volume loops. Pigs were studied at rest (baseline), after transient mechanical preload reduction and afterload increase, after 10-min of low dose dobutamine infusion (LDDS, 10 ug/kg/min, i.v), and esmolol administration (ESMO, bolus of 500 µg and continuous infusion of 100 µg·kg-1·min-1).
We detected a significant relationship between ESTVI and dP/dtmax during LDDS and ESMO administration. In addition, the fluctuations of ESTVI were significantly related to changes of the Ees during afterload increase, LDDS and ESMO infusion.
ESTVI signal detected in right cardiac chamber is significantly affected by acute changes in cardiac mechanical activity and is able to predict acute changes of LV inotropic state in normal heart.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0080591</identifier><identifier>PMID: 24260431</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Animals ; Aorta ; Blood Pressure ; Carotid arteries ; Catheters ; Critical care ; Electric Impedance ; Electrodes ; Fluctuations ; Heart ; Heart diseases ; Heart failure ; Heart Valves - physiology ; Hemodynamics ; Impedance ; Laboratories ; Life sciences ; Livestock ; Male ; Measuring instruments ; Models, Animal ; Muscle contraction ; Myocardial Contraction - physiology ; Prostheses and implants ; Stroke ; Stroke Volume ; Swine ; Systolic pressure ; Validation studies ; Veins & arteries ; Ventricle ; Ventricular Function, Left</subject><ispartof>PloS one, 2013-11, Vol.8 (11), p.e80591-e80591</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Lionetti et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/3.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Lionetti et al 2013 Lionetti et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-71ef7e9b8a851e11fe774afb24a280d7238e20bee708d0748b05dfdbf942a5213</citedby><cites>FETCH-LOGICAL-c692t-71ef7e9b8a851e11fe774afb24a280d7238e20bee708d0748b05dfdbf942a5213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834044/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834044/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24260431$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Moretti, Claudio</contributor><creatorcontrib>Lionetti, Vincenzo</creatorcontrib><creatorcontrib>Romano, Simone Lorenzo</creatorcontrib><creatorcontrib>Bianchi, Giacomo</creatorcontrib><creatorcontrib>Bernini, Fabio</creatorcontrib><creatorcontrib>Dushpanova, Anar</creatorcontrib><creatorcontrib>Mascia, Giuseppe</creatorcontrib><creatorcontrib>Nesti, Martina</creatorcontrib><creatorcontrib>Di Gregorio, Franco</creatorcontrib><creatorcontrib>Barbetta, Alberto</creatorcontrib><creatorcontrib>Padeletti, Luigi</creatorcontrib><title>Impact of acute changes of left ventricular contractility on the transvalvular impedance: validation study by pressure-volume loop analysis in healthy pigs</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The real-time and continuous assessment of left ventricular (LV) myocardial contractility through an implanted device is a clinically relevant goal. Transvalvular impedance (TVI) is an impedentiometric signal detected in the right cardiac chambers that changes during stroke volume fluctuations in patients. However, the relationship between TVI signals and LV contractility has not been proven. We investigated whether TVI signals predict changes of LV inotropic state during clinically relevant loading and inotropic conditions in swine normal heart.
The assessment of RVTVI signals was performed in anesthetized adult healthy anesthetized pigs (n = 6) instrumented for measurement of aortic and LV pressure, dP/dtmax and LV volumes. Myocardial contractility was assessed with the slope (Ees) of the LV end systolic pressure-volume relationship. Effective arterial elastance (Ea) and stroke work (SW) were determined from the LV pressure-volume loops. Pigs were studied at rest (baseline), after transient mechanical preload reduction and afterload increase, after 10-min of low dose dobutamine infusion (LDDS, 10 ug/kg/min, i.v), and esmolol administration (ESMO, bolus of 500 µg and continuous infusion of 100 µg·kg-1·min-1).
We detected a significant relationship between ESTVI and dP/dtmax during LDDS and ESMO administration. In addition, the fluctuations of ESTVI were significantly related to changes of the Ees during afterload increase, LDDS and ESMO infusion.
ESTVI signal detected in right cardiac chamber is significantly affected by acute changes in cardiac mechanical activity and is able to predict acute changes of LV inotropic state in normal heart.</description><subject>Analysis</subject><subject>Animals</subject><subject>Aorta</subject><subject>Blood Pressure</subject><subject>Carotid arteries</subject><subject>Catheters</subject><subject>Critical care</subject><subject>Electric Impedance</subject><subject>Electrodes</subject><subject>Fluctuations</subject><subject>Heart</subject><subject>Heart diseases</subject><subject>Heart failure</subject><subject>Heart Valves - physiology</subject><subject>Hemodynamics</subject><subject>Impedance</subject><subject>Laboratories</subject><subject>Life sciences</subject><subject>Livestock</subject><subject>Male</subject><subject>Measuring instruments</subject><subject>Models, Animal</subject><subject>Muscle contraction</subject><subject>Myocardial Contraction - physiology</subject><subject>Prostheses and implants</subject><subject>Stroke</subject><subject>Stroke Volume</subject><subject>Swine</subject><subject>Systolic pressure</subject><subject>Validation studies</subject><subject>Veins & arteries</subject><subject>Ventricle</subject><subject>Ventricular Function, 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Lorenzo</au><au>Bianchi, Giacomo</au><au>Bernini, Fabio</au><au>Dushpanova, Anar</au><au>Mascia, Giuseppe</au><au>Nesti, Martina</au><au>Di Gregorio, Franco</au><au>Barbetta, Alberto</au><au>Padeletti, Luigi</au><au>Moretti, Claudio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of acute changes of left ventricular contractility on the transvalvular impedance: validation study by pressure-volume loop analysis in healthy pigs</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-11-19</date><risdate>2013</risdate><volume>8</volume><issue>11</issue><spage>e80591</spage><epage>e80591</epage><pages>e80591-e80591</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The real-time and continuous assessment of left ventricular (LV) myocardial contractility through an implanted device is a clinically relevant goal. Transvalvular impedance (TVI) is an impedentiometric signal detected in the right cardiac chambers that changes during stroke volume fluctuations in patients. However, the relationship between TVI signals and LV contractility has not been proven. We investigated whether TVI signals predict changes of LV inotropic state during clinically relevant loading and inotropic conditions in swine normal heart.
The assessment of RVTVI signals was performed in anesthetized adult healthy anesthetized pigs (n = 6) instrumented for measurement of aortic and LV pressure, dP/dtmax and LV volumes. Myocardial contractility was assessed with the slope (Ees) of the LV end systolic pressure-volume relationship. Effective arterial elastance (Ea) and stroke work (SW) were determined from the LV pressure-volume loops. Pigs were studied at rest (baseline), after transient mechanical preload reduction and afterload increase, after 10-min of low dose dobutamine infusion (LDDS, 10 ug/kg/min, i.v), and esmolol administration (ESMO, bolus of 500 µg and continuous infusion of 100 µg·kg-1·min-1).
We detected a significant relationship between ESTVI and dP/dtmax during LDDS and ESMO administration. In addition, the fluctuations of ESTVI were significantly related to changes of the Ees during afterload increase, LDDS and ESMO infusion.
ESTVI signal detected in right cardiac chamber is significantly affected by acute changes in cardiac mechanical activity and is able to predict acute changes of LV inotropic state in normal heart.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24260431</pmid><doi>10.1371/journal.pone.0080591</doi><tpages>e80591</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-11, Vol.8 (11), p.e80591-e80591 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Analysis Animals Aorta Blood Pressure Carotid arteries Catheters Critical care Electric Impedance Electrodes Fluctuations Heart Heart diseases Heart failure Heart Valves - physiology Hemodynamics Impedance Laboratories Life sciences Livestock Male Measuring instruments Models, Animal Muscle contraction Myocardial Contraction - physiology Prostheses and implants Stroke Stroke Volume Swine Systolic pressure Validation studies Veins & arteries Ventricle Ventricular Function, Left |
| title | Impact of acute changes of left ventricular contractility on the transvalvular impedance: validation study by pressure-volume loop analysis in healthy pigs |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T23%3A12%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20acute%20changes%20of%20left%20ventricular%20contractility%20on%20the%20transvalvular%20impedance:%20validation%20study%20by%20pressure-volume%20loop%20analysis%20in%20healthy%20pigs&rft.jtitle=PloS%20one&rft.au=Lionetti,%20Vincenzo&rft.date=2013-11-19&rft.volume=8&rft.issue=11&rft.spage=e80591&rft.epage=e80591&rft.pages=e80591-e80591&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0080591&rft_dat=%3Cgale_plos_%3EA478207560%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1459676988&rft_id=info:pmid/24260431&rft_galeid=A478207560&rft_doaj_id=oai_doaj_org_article_67638663d3534f12bac20091178117e4&rfr_iscdi=true |