The LIM-only protein FHL2 attenuates lung inflammation during bleomycin-induced fibrosis

Fibrogenesis is usually initiated when regenerative processes have failed and/or chronic inflammation occurs. It is characterised by the activation of tissue fibroblasts and dysregulated synthesis of extracellular matrix proteins. FHL2 (four-and-a-half LIM domain protein 2) is a scaffolding protein...

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Veröffentlicht in:	PloS one 2013-11, Vol.8 (11), p.e81356
Hauptverfasser:	Alnajar, Abdulaleem, Nordhoff, Carolin, Schied, Tanja, Chiquet-Ehrismann, Ruth, Loser, Karin, Vogl, Thomas, Ludwig, Stephan, Wixler, Viktor
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Animal sciences Animals Bleomycin Cascades Cell activation Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism Cytokines DC-SIGN protein Extracellular matrix Extracellular Matrix - genetics Extracellular Matrix - metabolism Extracellular Matrix - pathology FHL2 protein Fibroblasts Fibroblasts - metabolism Fibroblasts - pathology Fibrosis Gene Expression Regulation Inflammation Kinases Laboratory animals Lectins, C-Type - genetics Lectins, C-Type - metabolism LIM protein LIM-Homeodomain Proteins - antagonists & inhibitors LIM-Homeodomain Proteins - genetics LIM-Homeodomain Proteins - metabolism Lungs Macrophage Activation Macrophages Macrophages, Peritoneal - metabolism Macrophages, Peritoneal - pathology Matrix protein Mice Molecular biology Muscle Proteins - antagonists & inhibitors Muscle Proteins - genetics Muscle Proteins - metabolism Muscles Pneumonia - chemically induced Pneumonia - genetics Pneumonia - metabolism Pneumonia - pathology Proteins Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - genetics Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Regulation Respiratory tract diseases RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Scaffolding Signal Transduction Signaling Smooth muscle Synthesis Tenascin Tenascin - genetics Tenascin - metabolism Tenascin C Transcription Transcription (Genetics) Transcription Factors - antagonists & inhibitors Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic Tumors Virology Wound healing Zoology
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