Polar lipids of Burkholderia pseudomallei induce different host immune responses

Melioidosis is a disease in tropical and subtropical regions of the world that is caused by Burkholderia pseudomallei. In endemic regions the disease occurs primarily in humans and goats. In the present study, we used the goat as a model to dissect the polar lipids of B. pseudomallei to identify lip...

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Veröffentlicht in:	PloS one 2013-11, Vol.8 (11), p.e80368-e80368
Hauptverfasser:	Gonzalez-Juarrero, Mercedes, Mima, Naoko, Trunck, Lily A, Schweizer, Herbert P, Bowen, Richard A, Dascher, Kyle, Mwangi, Waithaka, Eckstein, Torsten M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Analysis Animals Antibiotics Antigens Bacterial infections Burkholderia pseudomallei Burkholderia pseudomallei - immunology CD1 antigen CD25 antigen CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cytokines Dendritic cells Diagnostic software Diagnostic systems Female Glycolipids - immunology Glycolipids - metabolism Goats Goats - immunology Goats - metabolism HLA-DR alpha-Chains - immunology HLA-DR alpha-Chains - metabolism Immune response Immune system Immunology Infections Interferon Interferon-gamma - immunology Interferon-gamma - metabolism Interleukin 10 Interleukin 2 Interleukin 2 receptors Interleukin-10 - immunology Interleukin-10 - metabolism Lipids Lipids - immunology Lymphocytes Lymphocytes T Major histocompatibility complex Melioidosis Melioidosis - immunology Melioidosis - metabolism Monocytes Ornithine Ornithine - analogs & derivatives Ornithine - immunology Ornithine - metabolism Pathology Peripheral blood Phospholipids Phospholipids - immunology Phospholipids - metabolism Rhamnolipids T cells Up-Regulation - immunology Vaccines γ-Interferon
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