MAIT cells detect and efficiently lyse bacterially-infected epithelial cells

Mucosal associated invariant T cells (MAIT) are innate T lymphocytes that detect a large variety of bacteria and yeasts. This recognition depends on the detection of microbial compounds presented by the evolutionarily conserved major-histocompatibility-complex (MHC) class I molecule, MR1. Here we sh...

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Veröffentlicht in:	PLoS pathogens 2013-10, Vol.9 (10), p.e1003681-e1003681
Hauptverfasser:	Le Bourhis, Lionel, Dusseaux, Mathilde, Bohineust, Armelle, Bessoles, Stéphanie, Martin, Emmanuel, Premel, Virginie, Coré, Maxime, Sleurs, David, Serriari, Nacer-Eddine, Treiner, Emmanuel, Hivroz, Claire, Sansonetti, Philippe, Gougeon, Marie-Lise, Soudais, Claire, Lantz, Olivier
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Bacterial infections Bacteriology Cytotoxicity Dysentery, Bacillary - immunology Dysentery, Bacillary - pathology Epithelial cells Epithelial Cells - immunology Epithelial Cells - microbiology Epithelial Cells - pathology Experiments Female Genetic aspects Health aspects Histocompatibility Antigens Class I - immunology Host-parasite relationships Humans Immunity, Mucosal Intestinal Mucosa - immunology Intestinal Mucosa - microbiology Intestinal Mucosa - pathology Life Sciences Lymphocytes Major histocompatibility complex Male Microbiology Minor Histocompatibility Antigens NK Cell Lectin-Like Receptor Subfamily B - immunology Physiological aspects Salmonella Salmonella Infections - immunology Salmonella Infections - pathology Salmonella typhimurium - immunology Shigella dysenteriae - immunology Software T-Lymphocytes - immunology T-Lymphocytes - pathology
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