Type I J-domain NbMIP1 proteins are required for both Tobacco mosaic virus infection and plant innate immunity
Tm-2² is a coiled coil-nucleotide binding-leucine rich repeat resistance protein that confers durable extreme resistance against Tomato mosaic virus (ToMV) and Tobacco mosaic virus (TMV) by recognizing the viral movement protein (MP). Here we report that the Nicotiana benthamiana J-domain MIP1 prote...
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| creator | Du, Yumei Zhao, Jinping Chen, Tianyuan Liu, Qi Zhang, Haili Wang, Yan Hong, Yiguo Xiao, Fangming Zhang, Ling Shen, Qianhua Liu, Yule |
| description | Tm-2² is a coiled coil-nucleotide binding-leucine rich repeat resistance protein that confers durable extreme resistance against Tomato mosaic virus (ToMV) and Tobacco mosaic virus (TMV) by recognizing the viral movement protein (MP). Here we report that the Nicotiana benthamiana J-domain MIP1 proteins (NbMIP1s) associate with tobamovirus MP, Tm-2² and SGT1. Silencing of NbMIP1s reduced TMV movement and compromised Tm-2²-mediated resistance against TMV and ToMV. Furthermore, silencing of NbMIP1s reduced the steady-state protein levels of ToMV MP and Tm-2². Moreover, NbMIP1s are required for plant resistance induced by other R genes and the nonhost pathogen Pseudomonas syringae pv. tomato (Pst) DC3000. In addition, we found that SGT1 associates with Tm-2² and is required for Tm-2²-mediated resistance against TMV. These results suggest that NbMIP1s function as co-chaperones during virus infection and plant immunity. |
| doi_str_mv | 10.1371/journal.ppat.1003659 |
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Here we report that the Nicotiana benthamiana J-domain MIP1 proteins (NbMIP1s) associate with tobamovirus MP, Tm-2² and SGT1. Silencing of NbMIP1s reduced TMV movement and compromised Tm-2²-mediated resistance against TMV and ToMV. Furthermore, silencing of NbMIP1s reduced the steady-state protein levels of ToMV MP and Tm-2². Moreover, NbMIP1s are required for plant resistance induced by other R genes and the nonhost pathogen Pseudomonas syringae pv. tomato (Pst) DC3000. In addition, we found that SGT1 associates with Tm-2² and is required for Tm-2²-mediated resistance against TMV. These results suggest that NbMIP1s function as co-chaperones during virus infection and plant immunity.</description><identifier>ISSN: 1553-7374</identifier><identifier>ISSN: 1553-7366</identifier><identifier>EISSN: 1553-7374</identifier><identifier>DOI: 10.1371/journal.ppat.1003659</identifier><identifier>PMID: 24098120</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Apoptosis ; Disease Resistance - genetics ; Disease Resistance - immunology ; Experiments ; Glucosyltransferases - genetics ; Glucosyltransferases - immunology ; Health aspects ; Host-parasite relationships ; Infections ; Leaves ; Molecular Chaperones - genetics ; Molecular Chaperones - immunology ; Nicotiana - genetics ; Nicotiana - immunology ; Nicotiana - virology ; Physiological aspects ; Plant defenses ; Plant Diseases - genetics ; Plant Diseases - immunology ; Plant Diseases - virology ; Plant Proteins - genetics ; Plant Proteins - immunology ; Protein folding ; Protein Structure, Tertiary ; Pseudomonas syringae ; Tobacco ; Tobacco mosaic virus ; Tobacco Mosaic Virus - genetics ; Tobacco Mosaic Virus - immunology ; Viral infections ; Viral proteins</subject><ispartof>PLoS pathogens, 2013-10, Vol.9 (10), p.e1003659-e1003659</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Du et al 2013 Du et al</rights><rights>2013 Du et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Du Y, Zhao J, Chen T, Liu Q, Zhang H, et al. (2013) Type I J-Domain NbMIP1 Proteins Are Required for Both Tobacco Mosaic Virus Infection and Plant Innate Immunity. PLoS Pathog 9(10): e1003659. doi:10.1371/journal.ppat.1003659</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c633t-47c24bd011f4706b41a51b0b2509ad35b8f9bb154ef2ebfc6e3c8f7cdb87aef63</citedby><cites>FETCH-LOGICAL-c633t-47c24bd011f4706b41a51b0b2509ad35b8f9bb154ef2ebfc6e3c8f7cdb87aef63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789785/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789785/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24098120$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Dinesh-Kumar, Savithramma P.</contributor><creatorcontrib>Du, Yumei</creatorcontrib><creatorcontrib>Zhao, Jinping</creatorcontrib><creatorcontrib>Chen, Tianyuan</creatorcontrib><creatorcontrib>Liu, Qi</creatorcontrib><creatorcontrib>Zhang, Haili</creatorcontrib><creatorcontrib>Wang, Yan</creatorcontrib><creatorcontrib>Hong, Yiguo</creatorcontrib><creatorcontrib>Xiao, Fangming</creatorcontrib><creatorcontrib>Zhang, Ling</creatorcontrib><creatorcontrib>Shen, Qianhua</creatorcontrib><creatorcontrib>Liu, Yule</creatorcontrib><title>Type I J-domain NbMIP1 proteins are required for both Tobacco mosaic virus infection and plant innate immunity</title><title>PLoS pathogens</title><addtitle>PLoS Pathog</addtitle><description>Tm-2² is a coiled coil-nucleotide binding-leucine rich repeat resistance protein that confers durable extreme resistance against Tomato mosaic virus (ToMV) and Tobacco mosaic virus (TMV) by recognizing the viral movement protein (MP). Here we report that the Nicotiana benthamiana J-domain MIP1 proteins (NbMIP1s) associate with tobamovirus MP, Tm-2² and SGT1. Silencing of NbMIP1s reduced TMV movement and compromised Tm-2²-mediated resistance against TMV and ToMV. Furthermore, silencing of NbMIP1s reduced the steady-state protein levels of ToMV MP and Tm-2². Moreover, NbMIP1s are required for plant resistance induced by other R genes and the nonhost pathogen Pseudomonas syringae pv. tomato (Pst) DC3000. In addition, we found that SGT1 associates with Tm-2² and is required for Tm-2²-mediated resistance against TMV. These results suggest that NbMIP1s function as co-chaperones during virus infection and plant immunity.</description><subject>Apoptosis</subject><subject>Disease Resistance - genetics</subject><subject>Disease Resistance - immunology</subject><subject>Experiments</subject><subject>Glucosyltransferases - genetics</subject><subject>Glucosyltransferases - immunology</subject><subject>Health aspects</subject><subject>Host-parasite relationships</subject><subject>Infections</subject><subject>Leaves</subject><subject>Molecular Chaperones - genetics</subject><subject>Molecular Chaperones - immunology</subject><subject>Nicotiana - genetics</subject><subject>Nicotiana - immunology</subject><subject>Nicotiana - virology</subject><subject>Physiological aspects</subject><subject>Plant defenses</subject><subject>Plant Diseases - genetics</subject><subject>Plant Diseases - immunology</subject><subject>Plant Diseases - virology</subject><subject>Plant Proteins - genetics</subject><subject>Plant Proteins - immunology</subject><subject>Protein folding</subject><subject>Protein Structure, Tertiary</subject><subject>Pseudomonas syringae</subject><subject>Tobacco</subject><subject>Tobacco mosaic virus</subject><subject>Tobacco Mosaic Virus - genetics</subject><subject>Tobacco Mosaic Virus - immunology</subject><subject>Viral infections</subject><subject>Viral proteins</subject><issn>1553-7374</issn><issn>1553-7366</issn><issn>1553-7374</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNqVks1u1DAUhSMEomXgDRBYYgOLDHbsxMmmUlXxM6gUBMPaunbsqUeJndpOxbw9CTOtOhIblIWj6-8eXx-fLHtJ8JJQTt5v_RgcdMthgLQkGNOqbB5lp6Qsac4pZ48f_J9kz2LcYswIJdXT7KRguKlJgU8zt94NGq3Ql7z1PViHruTX1XeChuCTti4iCBoFfTPaoFtkfEDSp2u09hKU8qj3EaxCtzaMEVlntErWOwSuRUMHLk01B0kj2_ejs2n3PHtioIv6xWFdZL8-flhffM4vv31aXZxf5qqiNOWMq4LJFhNiGMeVZARKIrEsStxAS0tZm0ZKUjJtCi2NqjRVteGqlTUHbSq6yF7vdYfOR3GwKgrCyrqhxezLIlvtidbDVgzB9hB2woMVfws-bASEZFWnBSW80RRUoxRlGBRIwpqmpUaZqi0Im7TODqeNstet0i4F6I5Ej3ecvRYbfysorxtez8O8PQgEfzPqmERvo9LdZKH24zw3o4yUnM_omz26gWm0yXI_KaoZF-e0JA0r2XTFRbb8BzV9re6t8k4bO9WPGt4dNUxM0r_TBsYYxernj_9gr45ZtmdV8DEGbe5dIVjMOb57HDHnWBxyPLW9eujofdNdcOkftU_wCg</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Du, Yumei</creator><creator>Zhao, Jinping</creator><creator>Chen, Tianyuan</creator><creator>Liu, Qi</creator><creator>Zhang, Haili</creator><creator>Wang, Yan</creator><creator>Hong, Yiguo</creator><creator>Xiao, Fangming</creator><creator>Zhang, Ling</creator><creator>Shen, Qianhua</creator><creator>Liu, Yule</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISN</scope><scope>ISR</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20131001</creationdate><title>Type I J-domain NbMIP1 proteins are required for both Tobacco mosaic virus infection and plant innate immunity</title><author>Du, Yumei ; Zhao, Jinping ; Chen, Tianyuan ; Liu, Qi ; Zhang, Haili ; Wang, Yan ; Hong, Yiguo ; Xiao, Fangming ; Zhang, Ling ; Shen, Qianhua ; Liu, Yule</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c633t-47c24bd011f4706b41a51b0b2509ad35b8f9bb154ef2ebfc6e3c8f7cdb87aef63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Apoptosis</topic><topic>Disease Resistance - genetics</topic><topic>Disease Resistance - immunology</topic><topic>Experiments</topic><topic>Glucosyltransferases - genetics</topic><topic>Glucosyltransferases - immunology</topic><topic>Health aspects</topic><topic>Host-parasite relationships</topic><topic>Infections</topic><topic>Leaves</topic><topic>Molecular Chaperones - genetics</topic><topic>Molecular Chaperones - immunology</topic><topic>Nicotiana - genetics</topic><topic>Nicotiana - immunology</topic><topic>Nicotiana - virology</topic><topic>Physiological aspects</topic><topic>Plant defenses</topic><topic>Plant Diseases - genetics</topic><topic>Plant Diseases - immunology</topic><topic>Plant Diseases - virology</topic><topic>Plant Proteins - genetics</topic><topic>Plant Proteins - immunology</topic><topic>Protein folding</topic><topic>Protein Structure, Tertiary</topic><topic>Pseudomonas syringae</topic><topic>Tobacco</topic><topic>Tobacco mosaic virus</topic><topic>Tobacco Mosaic Virus - genetics</topic><topic>Tobacco Mosaic Virus - immunology</topic><topic>Viral infections</topic><topic>Viral proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Du, Yumei</creatorcontrib><creatorcontrib>Zhao, Jinping</creatorcontrib><creatorcontrib>Chen, Tianyuan</creatorcontrib><creatorcontrib>Liu, Qi</creatorcontrib><creatorcontrib>Zhang, Haili</creatorcontrib><creatorcontrib>Wang, Yan</creatorcontrib><creatorcontrib>Hong, Yiguo</creatorcontrib><creatorcontrib>Xiao, Fangming</creatorcontrib><creatorcontrib>Zhang, Ling</creatorcontrib><creatorcontrib>Shen, Qianhua</creatorcontrib><creatorcontrib>Liu, Yule</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Canada</collection><collection>Science (Gale in Context)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS pathogens</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Du, Yumei</au><au>Zhao, Jinping</au><au>Chen, Tianyuan</au><au>Liu, Qi</au><au>Zhang, Haili</au><au>Wang, Yan</au><au>Hong, Yiguo</au><au>Xiao, Fangming</au><au>Zhang, Ling</au><au>Shen, Qianhua</au><au>Liu, Yule</au><au>Dinesh-Kumar, Savithramma P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Type I J-domain NbMIP1 proteins are required for both Tobacco mosaic virus infection and plant innate immunity</atitle><jtitle>PLoS pathogens</jtitle><addtitle>PLoS Pathog</addtitle><date>2013-10-01</date><risdate>2013</risdate><volume>9</volume><issue>10</issue><spage>e1003659</spage><epage>e1003659</epage><pages>e1003659-e1003659</pages><issn>1553-7374</issn><issn>1553-7366</issn><eissn>1553-7374</eissn><abstract>Tm-2² is a coiled coil-nucleotide binding-leucine rich repeat resistance protein that confers durable extreme resistance against Tomato mosaic virus (ToMV) and Tobacco mosaic virus (TMV) by recognizing the viral movement protein (MP). Here we report that the Nicotiana benthamiana J-domain MIP1 proteins (NbMIP1s) associate with tobamovirus MP, Tm-2² and SGT1. Silencing of NbMIP1s reduced TMV movement and compromised Tm-2²-mediated resistance against TMV and ToMV. Furthermore, silencing of NbMIP1s reduced the steady-state protein levels of ToMV MP and Tm-2². Moreover, NbMIP1s are required for plant resistance induced by other R genes and the nonhost pathogen Pseudomonas syringae pv. tomato (Pst) DC3000. In addition, we found that SGT1 associates with Tm-2² and is required for Tm-2²-mediated resistance against TMV. These results suggest that NbMIP1s function as co-chaperones during virus infection and plant immunity.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24098120</pmid><doi>10.1371/journal.ppat.1003659</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Apoptosis Disease Resistance - genetics Disease Resistance - immunology Experiments Glucosyltransferases - genetics Glucosyltransferases - immunology Health aspects Host-parasite relationships Infections Leaves Molecular Chaperones - genetics Molecular Chaperones - immunology Nicotiana - genetics Nicotiana - immunology Nicotiana - virology Physiological aspects Plant defenses Plant Diseases - genetics Plant Diseases - immunology Plant Diseases - virology Plant Proteins - genetics Plant Proteins - immunology Protein folding Protein Structure, Tertiary Pseudomonas syringae Tobacco Tobacco mosaic virus Tobacco Mosaic Virus - genetics Tobacco Mosaic Virus - immunology Viral infections Viral proteins |
| title | Type I J-domain NbMIP1 proteins are required for both Tobacco mosaic virus infection and plant innate immunity |
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