APOBEC3G polymorphism as a selective barrier to cross-species transmission and emergence of pathogenic SIV and AIDS in a primate host

Cellular restriction factors, which render cells intrinsically resistant to viruses, potentially impose genetic barriers to cross-species transmission and emergence of viral pathogens in nature. One such factor is APOBEC3G. To overcome APOBEC3G-mediated restriction, many lentiviruses encode Vif, a p...

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Veröffentlicht in:	PLoS pathogens 2013-10, Vol.9 (10), p.e1003641-e1003641
Hauptverfasser:	Krupp, Annabel, McCarthy, Kevin R, Ooms, Marcel, Letko, Michael, Morgan, Jennifer S, Simon, Viviana, Johnson, Welkin E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome - enzymology Acquired Immunodeficiency Syndrome - genetics Acquired Immunodeficiency Syndrome - transmission Adaptation AIDS AIDS (Disease) Animals APOBEC-3G Deaminase Cercocebus atys Chlorocebus aethiops Cytidine Deaminase - genetics Cytidine Deaminase - metabolism Disease transmission Genetic aspects Genetic polymorphisms Health aspects HeLa Cells HIV Host-parasite relationships Human immunodeficiency virus Humans Hypotheses Macaca Medical research Monkeys & apes Physiological aspects Plasmids Polymorphism, Genetic Primates Proteins Simian Acquired Immunodeficiency Syndrome - enzymology Simian Acquired Immunodeficiency Syndrome - genetics Simian Acquired Immunodeficiency Syndrome - transmission Simian immunodeficiency virus Species Specificity Viral infections Viruses
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