eIF4EBP3L acts as a gatekeeper of TORC1 in activity-dependent muscle growth by specifically regulating Mef2ca translational initiation

Muscle fiber size is activity-dependent and clinically important in ageing, bed-rest, and cachexia, where muscle weakening leads to disability, prolonged recovery times, and increased costs. Inactivity causes muscle wasting by triggering protein degradation and may simultaneously prevent protein syn...

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Veröffentlicht in:	PLoS biology 2013-10, Vol.11 (10), p.e1001679-e1001679
Hauptverfasser:	Yogev, Orli, Williams, Victoria C, Hinits, Yaniv, Hughes, Simon M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding sites Carrier Proteins - genetics Carrier Proteins - metabolism Cell cycle Cell growth Embryos Experiments Gene expression Gene Expression Regulation, Developmental Gene Knockdown Techniques Genetic regulation Genetic translation Health aspects Kinases MEF2 Transcription Factors - genetics MEF2 Transcription Factors - metabolism Models, Biological Muscle proteins Muscle, Skeletal - growth & development Muscle, Skeletal - metabolism Muscular system Musculoskeletal system Myofibrils - metabolism Myogenic Regulatory Factors - genetics Myogenic Regulatory Factors - metabolism Myosin Heavy Chains - metabolism Peptide Chain Initiation, Translational - genetics Physiological aspects Protein synthesis Proteins Rapamycin Transcription Factors - metabolism Up-Regulation Zebrafish - genetics Zebrafish - growth & development Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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