Design principles of the yeast G1/S switch

A hallmark of the G1/S transition in budding yeast cell cycle is the proteolytic degradation of the B-type cyclin-Cdk stoichiometric inhibitor Sic1. Deleting SIC1 or altering Sic1 degradation dynamics increases genomic instability. Certain key facts about the parts of the G1/S circuitry are establis...

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Veröffentlicht in:	PLoS biology 2013-10, Vol.11 (10), p.e1001673-e1001673
Hauptverfasser:	Yang, Xiaojing, Lau, Kai-Yeung, Sevim, Volkan, Tang, Chao
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell cycle Feedback, Physiological G1 Phase Health aspects Kinases Medical research Phosphorylation Physiological aspects Proteolysis S Phase Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - metabolism Time Factors Yeast Yeast fungi
Online-Zugang:	Volltext
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