Global Population Structure of the Genes Encoding the Malaria Vaccine Candidate, Plasmodium vivax Apical Membrane Antigen 1 (PvAMA1)

The Plasmodium vivax Apical Membrane Antigen 1 (PvAMA1) is a promising malaria vaccine candidate, however it remains unclear which regions are naturally targeted by host immunity and whether its high genetic diversity will preclude coverage by a monovalent vaccine. To assess its feasibility as a vac...

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Veröffentlicht in:	PLoS neglected tropical diseases 2013-10, Vol.7 (10), p.e2506-e2506
Hauptverfasser:	Arnott, Alicia, Mueller, Ivo, Ramsland, Paul A, Siba, Peter M, Reeder, John C, Barry, Alyssa E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Antigens, Protozoan - genetics Child Child, Preschool Cluster Analysis Composition Cross-Sectional Studies DNA, Protozoan - chemistry DNA, Protozoan - genetics Female Genes Genetic aspects Global Health Haplotypes Humans Infant Infant, Newborn Malaria Malaria, Vivax - parasitology Male Medical research Membrane Proteins - genetics Middle Aged Molecular Sequence Data Parasite antigens Phylogeography Plasmodium falciparum Plasmodium vivax Plasmodium vivax - genetics Plasmodium vivax - isolation & purification Polymorphism, Single Nucleotide Protozoan Proteins - genetics Sequence Analysis, DNA Testing Vaccines Viral vaccines Young Adult
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