A study assessing the association of glycated hemoglobin A1C (HbA1C) associated variants with HbA1C, chronic kidney disease and diabetic retinopathy in populations of Asian ancestry
Glycated hemoglobin A1C (HbA1C) level is used as a diagnostic marker for diabetes mellitus and a predictor of diabetes associated complications. Genome-wide association studies have identified genetic variants associated with HbA1C level. Most of these studies have been conducted in populations of E...
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| Veröffentlicht in: | PloS one 2013-11, Vol.8 (11), p.e79767-e79767 |
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| creator | Chen, Peng Ong, Rick Twee-Hee Tay, Wan-Ting Sim, Xueling Ali, Mohammad Xu, Haiyan Suo, Chen Liu, Jianjun Chia, Kee-Seng Vithana, Eranga Young, Terri L Aung, Tin Lim, Wei-Yen Khor, Chiea-Chuen Cheng, Ching-Yu Wong, Tien-Yin Teo, Yik-Ying Tai, E-Shyong |
| description | Glycated hemoglobin A1C (HbA1C) level is used as a diagnostic marker for diabetes mellitus and a predictor of diabetes associated complications. Genome-wide association studies have identified genetic variants associated with HbA1C level. Most of these studies have been conducted in populations of European ancestry. Here we report the findings from a meta-analysis of genome-wide association studies of HbA1C levels in 6,682 non-diabetic subjects of Chinese, Malay and South Asian ancestries. We also sought to examine the associations between HbA1C associated SNPs and microvascular complications associated with diabetes mellitus, namely chronic kidney disease and retinopathy. A cluster of 6 SNPs on chromosome 17 showed an association with HbA1C which achieved genome-wide significance in the Malays but not in Chinese and Asian Indians. No other variants achieved genome-wide significance in the individual studies or in the meta-analysis. When we investigated the reproducibility of the findings that emerged from the European studies, six loci out of fifteen were found to be associated with HbA1C with effect sizes similar to those reported in the populations of European ancestry and P-value ≤ 0.05. No convincing associations with chronic kidney disease and retinopathy were identified in this study. |
| doi_str_mv | 10.1371/journal.pone.0079767 |
| format | Article |
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Genome-wide association studies have identified genetic variants associated with HbA1C level. Most of these studies have been conducted in populations of European ancestry. Here we report the findings from a meta-analysis of genome-wide association studies of HbA1C levels in 6,682 non-diabetic subjects of Chinese, Malay and South Asian ancestries. We also sought to examine the associations between HbA1C associated SNPs and microvascular complications associated with diabetes mellitus, namely chronic kidney disease and retinopathy. A cluster of 6 SNPs on chromosome 17 showed an association with HbA1C which achieved genome-wide significance in the Malays but not in Chinese and Asian Indians. No other variants achieved genome-wide significance in the individual studies or in the meta-analysis. When we investigated the reproducibility of the findings that emerged from the European studies, six loci out of fifteen were found to be associated with HbA1C with effect sizes similar to those reported in the populations of European ancestry and P-value ≤ 0.05. No convincing associations with chronic kidney disease and retinopathy were identified in this study.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0079767</identifier><identifier>PMID: 24244560</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Asian people ; Asian People - genetics ; Bioinformatics ; Cardiovascular disease ; Chromosome 17 ; Complications ; Diabetes ; Diabetes mellitus ; Diabetic retinopathy ; Diabetic Retinopathy - blood ; Diabetic Retinopathy - epidemiology ; Diabetic Retinopathy - genetics ; Diagnostic systems ; Ethics ; Ethnicity - genetics ; Female ; Genetic Association Studies ; Genetic diversity ; Genetic variance ; Genome-wide association studies ; Genome-Wide Association Study ; Genomes ; Genotype ; Glucose ; Glycated Hemoglobin - genetics ; Glycated Hemoglobin - metabolism ; Hemoglobin ; Humans ; Kidney diseases ; Kidneys ; Life sciences ; Male ; Meta-analysis ; Meta-Analysis as Topic ; Microvasculature ; Middle Aged ; Mortality ; Phenotype ; Polymorphism, Single Nucleotide ; Populations ; Prevalence ; Principal components analysis ; Public health ; Renal Insufficiency, Chronic - blood ; Renal Insufficiency, Chronic - epidemiology ; Renal Insufficiency, Chronic - genetics ; Reproducibility ; Retinopathy ; Singapore ; Single-nucleotide polymorphism ; Studies ; White People - genetics ; Young Adult</subject><ispartof>PloS one, 2013-11, Vol.8 (11), p.e79767-e79767</ispartof><rights>2013 Peng Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Peng Chen 2013 Peng Chen</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-c04e31343a886bfabd96f9019d430835c694d3137ec04775241070f2f31b288a3</citedby><cites>FETCH-LOGICAL-c526t-c04e31343a886bfabd96f9019d430835c694d3137ec04775241070f2f31b288a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820602/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820602/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24244560$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>He, Mingguang</contributor><creatorcontrib>Chen, Peng</creatorcontrib><creatorcontrib>Ong, Rick Twee-Hee</creatorcontrib><creatorcontrib>Tay, Wan-Ting</creatorcontrib><creatorcontrib>Sim, Xueling</creatorcontrib><creatorcontrib>Ali, Mohammad</creatorcontrib><creatorcontrib>Xu, Haiyan</creatorcontrib><creatorcontrib>Suo, Chen</creatorcontrib><creatorcontrib>Liu, Jianjun</creatorcontrib><creatorcontrib>Chia, Kee-Seng</creatorcontrib><creatorcontrib>Vithana, Eranga</creatorcontrib><creatorcontrib>Young, Terri L</creatorcontrib><creatorcontrib>Aung, Tin</creatorcontrib><creatorcontrib>Lim, Wei-Yen</creatorcontrib><creatorcontrib>Khor, Chiea-Chuen</creatorcontrib><creatorcontrib>Cheng, Ching-Yu</creatorcontrib><creatorcontrib>Wong, Tien-Yin</creatorcontrib><creatorcontrib>Teo, Yik-Ying</creatorcontrib><creatorcontrib>Tai, E-Shyong</creatorcontrib><title>A study assessing the association of glycated hemoglobin A1C (HbA1C) associated variants with HbA1C, chronic kidney disease and diabetic retinopathy in populations of Asian ancestry</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Glycated hemoglobin A1C (HbA1C) level is used as a diagnostic marker for diabetes mellitus and a predictor of diabetes associated complications. Genome-wide association studies have identified genetic variants associated with HbA1C level. Most of these studies have been conducted in populations of European ancestry. Here we report the findings from a meta-analysis of genome-wide association studies of HbA1C levels in 6,682 non-diabetic subjects of Chinese, Malay and South Asian ancestries. We also sought to examine the associations between HbA1C associated SNPs and microvascular complications associated with diabetes mellitus, namely chronic kidney disease and retinopathy. A cluster of 6 SNPs on chromosome 17 showed an association with HbA1C which achieved genome-wide significance in the Malays but not in Chinese and Asian Indians. No other variants achieved genome-wide significance in the individual studies or in the meta-analysis. When we investigated the reproducibility of the findings that emerged from the European studies, six loci out of fifteen were found to be associated with HbA1C with effect sizes similar to those reported in the populations of European ancestry and P-value ≤ 0.05. No convincing associations with chronic kidney disease and retinopathy were identified in this study.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Asian people</subject><subject>Asian People - genetics</subject><subject>Bioinformatics</subject><subject>Cardiovascular disease</subject><subject>Chromosome 17</subject><subject>Complications</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetic retinopathy</subject><subject>Diabetic Retinopathy - blood</subject><subject>Diabetic Retinopathy - epidemiology</subject><subject>Diabetic Retinopathy - genetics</subject><subject>Diagnostic systems</subject><subject>Ethics</subject><subject>Ethnicity - genetics</subject><subject>Female</subject><subject>Genetic Association Studies</subject><subject>Genetic diversity</subject><subject>Genetic variance</subject><subject>Genome-wide association studies</subject><subject>Genome-Wide Association Study</subject><subject>Genomes</subject><subject>Genotype</subject><subject>Glucose</subject><subject>Glycated Hemoglobin - genetics</subject><subject>Glycated Hemoglobin - metabolism</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Kidney diseases</subject><subject>Kidneys</subject><subject>Life sciences</subject><subject>Male</subject><subject>Meta-analysis</subject><subject>Meta-Analysis as Topic</subject><subject>Microvasculature</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Phenotype</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Populations</subject><subject>Prevalence</subject><subject>Principal components analysis</subject><subject>Public health</subject><subject>Renal Insufficiency, Chronic - blood</subject><subject>Renal Insufficiency, Chronic - epidemiology</subject><subject>Renal Insufficiency, Chronic - genetics</subject><subject>Reproducibility</subject><subject>Retinopathy</subject><subject>Singapore</subject><subject>Single-nucleotide polymorphism</subject><subject>Studies</subject><subject>White People - genetics</subject><subject>Young 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study assessing the association of glycated hemoglobin A1C (HbA1C) associated variants with HbA1C, chronic kidney disease and diabetic retinopathy in populations of Asian ancestry</title><author>Chen, Peng ; Ong, Rick Twee-Hee ; Tay, Wan-Ting ; Sim, Xueling ; Ali, Mohammad ; Xu, Haiyan ; Suo, Chen ; Liu, Jianjun ; Chia, Kee-Seng ; Vithana, Eranga ; Young, Terri L ; Aung, Tin ; Lim, Wei-Yen ; Khor, Chiea-Chuen ; Cheng, Ching-Yu ; Wong, Tien-Yin ; Teo, Yik-Ying ; Tai, E-Shyong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-c04e31343a886bfabd96f9019d430835c694d3137ec04775241070f2f31b288a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Asian people</topic><topic>Asian People - genetics</topic><topic>Bioinformatics</topic><topic>Cardiovascular disease</topic><topic>Chromosome 17</topic><topic>Complications</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetic retinopathy</topic><topic>Diabetic Retinopathy - blood</topic><topic>Diabetic Retinopathy - epidemiology</topic><topic>Diabetic Retinopathy - genetics</topic><topic>Diagnostic systems</topic><topic>Ethics</topic><topic>Ethnicity - genetics</topic><topic>Female</topic><topic>Genetic Association Studies</topic><topic>Genetic diversity</topic><topic>Genetic variance</topic><topic>Genome-wide association studies</topic><topic>Genome-Wide Association Study</topic><topic>Genomes</topic><topic>Genotype</topic><topic>Glucose</topic><topic>Glycated Hemoglobin - genetics</topic><topic>Glycated Hemoglobin - metabolism</topic><topic>Hemoglobin</topic><topic>Humans</topic><topic>Kidney diseases</topic><topic>Kidneys</topic><topic>Life sciences</topic><topic>Male</topic><topic>Meta-analysis</topic><topic>Meta-Analysis as Topic</topic><topic>Microvasculature</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Phenotype</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Populations</topic><topic>Prevalence</topic><topic>Principal components analysis</topic><topic>Public health</topic><topic>Renal Insufficiency, Chronic - blood</topic><topic>Renal Insufficiency, Chronic - epidemiology</topic><topic>Renal Insufficiency, Chronic - genetics</topic><topic>Reproducibility</topic><topic>Retinopathy</topic><topic>Singapore</topic><topic>Single-nucleotide polymorphism</topic><topic>Studies</topic><topic>White People - genetics</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Peng</creatorcontrib><creatorcontrib>Ong, Rick Twee-Hee</creatorcontrib><creatorcontrib>Tay, Wan-Ting</creatorcontrib><creatorcontrib>Sim, Xueling</creatorcontrib><creatorcontrib>Ali, Mohammad</creatorcontrib><creatorcontrib>Xu, Haiyan</creatorcontrib><creatorcontrib>Suo, 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Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Peng</au><au>Ong, Rick Twee-Hee</au><au>Tay, Wan-Ting</au><au>Sim, Xueling</au><au>Ali, Mohammad</au><au>Xu, Haiyan</au><au>Suo, Chen</au><au>Liu, Jianjun</au><au>Chia, Kee-Seng</au><au>Vithana, Eranga</au><au>Young, Terri L</au><au>Aung, Tin</au><au>Lim, Wei-Yen</au><au>Khor, Chiea-Chuen</au><au>Cheng, Ching-Yu</au><au>Wong, Tien-Yin</au><au>Teo, Yik-Ying</au><au>Tai, E-Shyong</au><au>He, Mingguang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A study assessing the association of glycated hemoglobin A1C (HbA1C) associated variants with HbA1C, chronic kidney disease and diabetic retinopathy in populations of Asian ancestry</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-11-07</date><risdate>2013</risdate><volume>8</volume><issue>11</issue><spage>e79767</spage><epage>e79767</epage><pages>e79767-e79767</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Glycated hemoglobin A1C (HbA1C) level is used as a diagnostic marker for diabetes mellitus and a predictor of diabetes associated complications. Genome-wide association studies have identified genetic variants associated with HbA1C level. Most of these studies have been conducted in populations of European ancestry. Here we report the findings from a meta-analysis of genome-wide association studies of HbA1C levels in 6,682 non-diabetic subjects of Chinese, Malay and South Asian ancestries. We also sought to examine the associations between HbA1C associated SNPs and microvascular complications associated with diabetes mellitus, namely chronic kidney disease and retinopathy. A cluster of 6 SNPs on chromosome 17 showed an association with HbA1C which achieved genome-wide significance in the Malays but not in Chinese and Asian Indians. No other variants achieved genome-wide significance in the individual studies or in the meta-analysis. When we investigated the reproducibility of the findings that emerged from the European studies, six loci out of fifteen were found to be associated with HbA1C with effect sizes similar to those reported in the populations of European ancestry and P-value ≤ 0.05. No convincing associations with chronic kidney disease and retinopathy were identified in this study.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24244560</pmid><doi>10.1371/journal.pone.0079767</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-11, Vol.8 (11), p.e79767-e79767 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1458280869 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Aged Aged, 80 and over Asian people Asian People - genetics Bioinformatics Cardiovascular disease Chromosome 17 Complications Diabetes Diabetes mellitus Diabetic retinopathy Diabetic Retinopathy - blood Diabetic Retinopathy - epidemiology Diabetic Retinopathy - genetics Diagnostic systems Ethics Ethnicity - genetics Female Genetic Association Studies Genetic diversity Genetic variance Genome-wide association studies Genome-Wide Association Study Genomes Genotype Glucose Glycated Hemoglobin - genetics Glycated Hemoglobin - metabolism Hemoglobin Humans Kidney diseases Kidneys Life sciences Male Meta-analysis Meta-Analysis as Topic Microvasculature Middle Aged Mortality Phenotype Polymorphism, Single Nucleotide Populations Prevalence Principal components analysis Public health Renal Insufficiency, Chronic - blood Renal Insufficiency, Chronic - epidemiology Renal Insufficiency, Chronic - genetics Reproducibility Retinopathy Singapore Single-nucleotide polymorphism Studies White People - genetics Young Adult |
| title | A study assessing the association of glycated hemoglobin A1C (HbA1C) associated variants with HbA1C, chronic kidney disease and diabetic retinopathy in populations of Asian ancestry |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T00%3A57%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20study%20assessing%20the%20association%20of%20glycated%20hemoglobin%20A1C%20(HbA1C)%20associated%20variants%20with%20HbA1C,%20chronic%20kidney%20disease%20and%20diabetic%20retinopathy%20in%20populations%20of%20Asian%20ancestry&rft.jtitle=PloS%20one&rft.au=Chen,%20Peng&rft.date=2013-11-07&rft.volume=8&rft.issue=11&rft.spage=e79767&rft.epage=e79767&rft.pages=e79767-e79767&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0079767&rft_dat=%3Cproquest_plos_%3E3126413591%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1458280869&rft_id=info:pmid/24244560&rft_doaj_id=oai_doaj_org_article_60964d72adbc4b3f9a9d07c36378fa81&rfr_iscdi=true |