Regulation of epithelial differentiation in rat intestine by intraluminal delivery of an adenoviral vector or silencing RNA coding for Schlafen 3

Although we stimulate enterocytic proliferation to ameliorate short gut syndrome or mucosal atrophy, less effort has been directed at enterocytic differentiation. Schlafen 3 (Slfn3) is a poorly understood protein induced during IEC-6 enterocytic differentiation. We hypothesized that exogenous manipu...

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Veröffentlicht in:	PloS one 2013-11, Vol.8 (11), p.e79745-e79745
Hauptverfasser:	Kovalenko, Pavlo L, Yuan, Lisi, Sun, Kelian, Kunovska, Lyudmyla, Seregin, Sergey, Amalfitano, Andrea, Basson, Marc D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Advertising executives AKT protein Anastomosis Animals Apoptosis Atrophy Biomarkers Caco-2 Cells Cell cycle Cell Differentiation - genetics Cell Proliferation Crypts Differentiation Digestive system Digestive tract Dingell, John D Enteral nutrition Epithelial cells Experiments Gastrointestinal tract Gene Expression Gene Transfer Techniques Genetic Vectors - genetics Glucose transporter Humans Immunohistochemistry Intestinal Mucosa - cytology Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Intestine Jejunum Jejunum - metabolism Kinases Laboratory animals Male Markers Microfilament Proteins - genetics mRNA Mucosa Nutrition Parenteral nutrition Phosphorylation Proteins - genetics Rats Ribonucleic acid RNA RNA, Messenger - genetics RNA, Small Interfering - genetics RNA-mediated interference Rodents Signaling Surgery Target recognition Transduction, Genetic Transfection Transgenes Villus
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