Genetic deletion of afadin causes hydrocephalus by destruction of adherens junctions in radial glial and ependymal cells in the midbrain

Adherens junctions (AJs) play a role in mechanically connecting adjacent cells to maintain tissue structure, particularly in epithelial cells. The major cell-cell adhesion molecules at AJs are cadherins and nectins. Afadin binds to both nectins and α-catenin and recruits the cadherin-β-catenin compl...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2013-11, Vol.8 (11), p.e80356
Hauptverfasser:	Yamamoto, Hideaki, Maruo, Tomohiko, Majima, Takashi, Ishizaki, Hiroyoshi, Tanaka-Okamoto, Miki, Miyoshi, Jun, Mandai, Kenji, Takai, Yoshimi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adherens junctions Adherens Junctions - pathology Adhesion Animals Biochemistry Brain Cadherins Cancer Cardiovascular disease Cell adhesion Cell adhesion & migration Cell adhesion molecules Cellular biology Cerebral Aqueduct - metabolism Cerebral Aqueduct - pathology Clonal deletion Destruction Disease Models, Animal Ependymal cells Ependymoglial Cells - metabolism Ependymoglial Cells - pathology Epithelial cells Gene Deletion Glial cells Hydrocephalus Hydrocephalus - genetics Hydrocephalus - pathology Intermediate filament proteins Medicine Mesencephalon Mesencephalon - metabolism Mesencephalon - pathology Mice Mice, Knockout Microfilament Proteins - genetics Molecular biology Morphogenesis N-Cadherin Nectin Nestin Neurons Neurons - metabolism Phenotype Protein Transport Proteins Radial glial cells Rodents Science Stenosis Third Ventricle - metabolism Third Ventricle - pathology University graduates Ventricle Ventricle (lateral) Ventricles (cerebral) Ventricular zone α-Catenin β-Catenin
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!