Recurrent chromosome 22 deletions in osteoblastoma affect inhibitors of the Wnt/beta-catenin signaling pathway

Osteoblastoma is a bone forming tumor with histological features highly similar to osteoid osteoma; the discrimination between the tumor types is based on size and growth pattern. The vast majority of osteoblastomas are benign but there is a group of so-called aggressive osteoblastomas that can be d...

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Veröffentlicht in:	PloS one 2013-11, Vol.8 (11), p.e80725
Hauptverfasser:	Nord, Karolin H, Nilsson, Jenny, Arbajian, Elsa, Vult von Steyern, Fredrik, Brosjö, Otte, Cleton-Jansen, Anne-Marie, Szuhai, Karoly, Hogendoorn, Pancras C W
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Adolescent Adult Analysis Basic Medicine Biocompatibility Bone cancer Bone lesions Bone Neoplasms - genetics Bone Neoplasms - metabolism Child Chromosome 22 Chromosome Deletion Chromosomes Chromosomes, Human, Pair 22 Clinical Medicine Cluster Analysis DNA Copy Number Variations Female Gastric cancer Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Genes Genetic disorders Genetics Genomes Genomics Humans Inhibitors Klinisk medicin Laboratories Lesions Leukemia Male Medical and Health Sciences Medical Genetics Medicin och hälsovetenskap Medicinsk genetik Medicinska och farmaceutiska grundvetenskaper Morphology Mutation Neurological disorders Orthopedics Ortopedi Osteoblastoma Osteoblastoma - genetics Osteoblastoma - metabolism Osteogenesis Osteoid Osteoid osteoma Osteoma Osteosarcoma Patients Polymorphism, Single Nucleotide Principal components analysis Sarcoma Signal transduction Signaling Single-nucleotide polymorphism Solid tumors Stem cells Stomach cancer Tumorigenesis Tumors Vertebra Vertebrae Wnt protein Wnt Signaling Pathway Young Adult β-Catenin
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