Heterogeneity of functional properties of Clone 66 murine breast cancer cells expressing various stem cell phenotypes

Breast cancer grows, metastasizes and relapses from rare, therapy resistant cells with a stem cell phenotype (cancer stem cells/CSCs). However, there is a lack of studies comparing the functions of CSCs isolated using different phenotypes in order to determine if CSCs are homogeneous or heterogeneou...

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Veröffentlicht in:	PloS one 2013-11, Vol.8 (11), p.e78725
Hauptverfasser:	Mukhopadhyay, Partha, Farrell, Tracy, Sharma, Gayatri, McGuire, Timothy R, O'Kane, Barbara, Sharp, J Graham
Format:	Artikel
Sprache:	eng
Schlagworte:	Agar Angiogenesis Animals Biomarkers, Tumor - metabolism Breast cancer Cancer Cancer cells Carcinogenesis Cell adhesion & migration Cell Line, Tumor Cell Proliferation Cell Transplantation Chemokines Chemokines - biosynthesis Chemokines - metabolism Clone Cells - metabolism Clone Cells - pathology Cloning Colonies Comparative analysis Cytokines Dilution Female Gene Expression Regulation, Neoplastic Genetic aspects Growth factors Heterogeneity Humans Leukemia Lymphoma Mammary Neoplasms, Experimental - metabolism Mammary Neoplasms, Experimental - pathology Melanoma Metastasis Mice Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Phenotype Phenotypes Populations Properties (attributes) RANTES Skin cancer Stem cell transplantation Stem cells Stromal Cells - pathology Syngeneic grafts Tumorigenesis Tumors
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