Effects of bone marrow-derived mesenchymal stem cells on the axonal outgrowth through activation of PI3K/AKT signaling in primary cortical neurons followed oxygen-glucose deprivation injury

Transplantation with bone marrow-derived mesenchymal stem cells (BMSCs) improves the survival of neurons and axonal outgrowth after stroke remains undetermined. Here, we investigated whether PI3K/AKT signaling pathway is involved in these therapeutic effects of BMSCs. (1) BMSCs and cortical neurons...

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Veröffentlicht in:	PloS one 2013-11, Vol.8 (11), p.e78514-e78514
Hauptverfasser:	Liu, Yong, Zhang, Yixian, Lin, Longzai, Lin, Feifei, Li, Tin, Du, Houwei, Chen, Ronghua, Zheng, Wei, Liu, Nan
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Analysis Animals Axons Axons - metabolism Bone marrow Bone Marrow Cells - cytology Bone marrow transplantation Brain - cytology Brain research Cell culture Cell cycle Cell Survival Conditioning Damage assessment Deprivation Enzyme inhibitors Female GAP-43 protein GAP-43 Protein - metabolism Gene Expression Regulation Glucose Glucose - deficiency Health aspects Inhibitors Injuries Insulin-like growth factors Ischemia Kinases Laboratory animals Mesenchymal Stem Cell Transplantation Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchyme Neurogenesis Neurology Neurons Oxygen Oxygen - metabolism Paracrine signalling Phosphatidylinositol 3-Kinases - metabolism Pregnancy Proteins Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Sprague-Dawley Rodents Signal Transduction Stem cells Stroke Survival Transplantation Transplants & implants Western blotting
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