Efficacy of cyclin dependent kinase 4 inhibitors as potent neuroprotective agents against insults relevant to Alzheimer's disease

Alzheimer's disease (AD) is a progressive neurodegenerative disease with no cure till today. Aberrant activation of cell cycle regulatory proteins is implicated in neurodegenerative diseases including AD. We and others have shown that Cyclin dependent kinase 4 (Cdk4) is activated in AD brain an...

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Veröffentlicht in:	PloS one 2013-11, Vol.8 (11), p.e78842-e78842
Hauptverfasser:	Sanphui, Priyankar, Pramanik, Sumit Kumar, Chatterjee, Nandini, Moorthi, Ponnusamy, Banerji, Biswadip, Biswas, Subhas Chandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Advertising executives Alzheimer Disease - drug therapy Alzheimer Disease - enzymology Alzheimer Disease - pathology Alzheimer's disease Animals Anti-Alzheimer's disease agents Apoptosis Apoptosis Regulatory Proteins - metabolism Bcl-2-Like Protein 11 BIM protein Biology Brain Caspase 3 - metabolism Cell activation Cell cycle Cell death Cell Death - drug effects Chemical synthesis Chemistry Coupling (molecular) Cyclin-dependent kinase 4 Cyclin-Dependent Kinase 4 - antagonists & inhibitors Cyclin-Dependent Kinase 4 - metabolism Cyclin-dependent kinases Death Dementia Deprivation Disease Drug development Gene expression Inhibitors Kinases Membrane Proteins - metabolism Mitochondria Molecular modelling Mortality Naphthalene Nerve growth factor Nerve Growth Factor - metabolism Neurodegeneration Neurodegenerative diseases Neurological diseases Neurons Neurons - enzymology Neurons - pathology Neuroprotection Neuroprotective agents Neuroprotective Agents - chemistry Neuroprotective Agents - pharmacology Neurosciences Pathology PC12 Cells Phenanthrene Physiology Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Proteins Proto-Oncogene Proteins - metabolism Rats Regulatory proteins Transcription factors β-Amyloid
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