Echocardiography, spirometry, and systemic acute-phase inflammatory proteins in smokers with COPD or CHF: an observational study
Chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) may coexist in elderly patients with a history of smoking. Low-grade systemic inflammation induced by smoking may represent the link between these 2 conditions. In this study, we investigated left ventricular dysfunction in...
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| Veröffentlicht in: | PloS one 2013-11, Vol.8 (11), p.e80166-e80166 |
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| creator | Beghé, Bianca Verduri, Alessia Bottazzi, Barbara Stendardo, Mariarita Fucili, Alessandro Balduzzi, Sara Leuzzi, Chiara Papi, Alberto Mantovani, Alberto Fabbri, Leonardo M Ceconi, Claudio Boschetto, Piera |
| description | Chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) may coexist in elderly patients with a history of smoking. Low-grade systemic inflammation induced by smoking may represent the link between these 2 conditions. In this study, we investigated left ventricular dysfunction in patients primarily diagnosed with COPD, and nonreversible airflow limitation in patients primarily diagnosed with CHF. The levels of circulating high-sensitive C-reactive protein (Hs-CRP), pentraxin 3 (PTX3), interleukin-1β (IL-1 β), and soluble type II receptor of IL-1 (sIL-1RII) were also measured as markers of systemic inflammation in these 2 cohorts. Patients aged ≥ 50 years and with ≥ 10 pack years of cigarette smoking who presented with a diagnosis of stable COPD (n=70) or stable CHF (n=124) were recruited. All patients underwent echocardiography, N-terminal pro-hormone of brain natriuretic peptide measurements, and post-bronchodilator spirometry. Plasma levels of Hs-CRP, PTX3, IL-1 β, and sIL-1RII were determined by using a sandwich enzyme-linked immuno-sorbent assay in all patients and in 24 healthy smokers (control subjects). Although we were unable to find a single COPD patient with left ventricular dysfunction, we found nonreversible airflow limitation in 34% of patients with CHF. On the other hand, COPD patients had higher plasma levels of Hs-CRP, IL1 β, and sIL-1RII compared with CHF patients and control subjects (p < 0.05). None of the inflammatory biomarkers was different between CHF patients and control subjects. In conclusion, although the COPD patients had no evidence of CHF, up to one third of patients with CHF had airflow limitation, suggesting that routine spirometry is warranted in patients with CHF, whereas echocardiography is not required in well characterized patients with COPD. Only smokers with COPD seem to have evidence of systemic inflammation. |
| doi_str_mv | 10.1371/journal.pone.0080166 |
| format | Article |
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Low-grade systemic inflammation induced by smoking may represent the link between these 2 conditions. In this study, we investigated left ventricular dysfunction in patients primarily diagnosed with COPD, and nonreversible airflow limitation in patients primarily diagnosed with CHF. The levels of circulating high-sensitive C-reactive protein (Hs-CRP), pentraxin 3 (PTX3), interleukin-1β (IL-1 β), and soluble type II receptor of IL-1 (sIL-1RII) were also measured as markers of systemic inflammation in these 2 cohorts. Patients aged ≥ 50 years and with ≥ 10 pack years of cigarette smoking who presented with a diagnosis of stable COPD (n=70) or stable CHF (n=124) were recruited. All patients underwent echocardiography, N-terminal pro-hormone of brain natriuretic peptide measurements, and post-bronchodilator spirometry. Plasma levels of Hs-CRP, PTX3, IL-1 β, and sIL-1RII were determined by using a sandwich enzyme-linked immuno-sorbent assay in all patients and in 24 healthy smokers (control subjects). Although we were unable to find a single COPD patient with left ventricular dysfunction, we found nonreversible airflow limitation in 34% of patients with CHF. On the other hand, COPD patients had higher plasma levels of Hs-CRP, IL1 β, and sIL-1RII compared with CHF patients and control subjects (p < 0.05). None of the inflammatory biomarkers was different between CHF patients and control subjects. In conclusion, although the COPD patients had no evidence of CHF, up to one third of patients with CHF had airflow limitation, suggesting that routine spirometry is warranted in patients with CHF, whereas echocardiography is not required in well characterized patients with COPD. Only smokers with COPD seem to have evidence of systemic inflammation.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0080166</identifier><identifier>PMID: 24244639</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Air flow ; Biomarkers ; Biomarkers - blood ; Brain ; Brain natriuretic peptide ; Bronchodilators ; C-reactive protein ; C-Reactive Protein - metabolism ; Cardiology ; Cardiovascular disease ; Case-Control Studies ; Chronic Disease ; Chronic illnesses ; Chronic obstructive lung disease ; Chronic obstructive pulmonary disease ; Cigarette smoking ; Comorbidity ; Coronary artery disease ; Cytokines ; Echocardiography ; Female ; Geriatrics ; Heart diseases ; Heart failure ; Heart Failure - blood ; Heart Failure - diagnosis ; Heart Failure - diagnostic imaging ; Heart Failure - physiopathology ; Hospitals ; Humans ; Immunology ; Inflammation ; Inflammation - blood ; Inflammation - diagnosis ; Inflammation - diagnostic imaging ; Inflammation - physiopathology ; Interleukin 1 ; Interleukin-1beta - blood ; Interleukins ; Laboratories ; Lung diseases ; Male ; Medical research ; Middle Aged ; Natriuretic Peptide, Brain - blood ; Natriuretic peptides ; Observational studies ; Obstructive lung disease ; Older people ; Patients ; Pentraxins ; Peptide Fragments - blood ; Plasma levels ; Proteins ; Pulmonary Disease, Chronic Obstructive - blood ; Pulmonary Disease, Chronic Obstructive - diagnosis ; Pulmonary Disease, Chronic Obstructive - diagnostic imaging ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Receptors, Interleukin-1 Type II - blood ; Serum Amyloid P-Component - metabolism ; Smokers ; Smoking ; Smoking - physiopathology ; Spirometry ; Thorax ; Ultrasonography ; Ventricle ; Ventricular Dysfunction, Left - blood</subject><ispartof>PloS one, 2013-11, Vol.8 (11), p.e80166-e80166</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Beghé et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Beghé et al 2013 Beghé et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-a661610c94fb7cd145e2426da8b4fef02116e7bd0d5b7bd31fb5663607ace5d13</citedby><cites>FETCH-LOGICAL-c692t-a661610c94fb7cd145e2426da8b4fef02116e7bd0d5b7bd31fb5663607ace5d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823838/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823838/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24244639$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beghé, Bianca</creatorcontrib><creatorcontrib>Verduri, Alessia</creatorcontrib><creatorcontrib>Bottazzi, Barbara</creatorcontrib><creatorcontrib>Stendardo, Mariarita</creatorcontrib><creatorcontrib>Fucili, Alessandro</creatorcontrib><creatorcontrib>Balduzzi, Sara</creatorcontrib><creatorcontrib>Leuzzi, Chiara</creatorcontrib><creatorcontrib>Papi, Alberto</creatorcontrib><creatorcontrib>Mantovani, Alberto</creatorcontrib><creatorcontrib>Fabbri, Leonardo M</creatorcontrib><creatorcontrib>Ceconi, Claudio</creatorcontrib><creatorcontrib>Boschetto, Piera</creatorcontrib><title>Echocardiography, spirometry, and systemic acute-phase inflammatory proteins in smokers with COPD or CHF: an observational study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) may coexist in elderly patients with a history of smoking. Low-grade systemic inflammation induced by smoking may represent the link between these 2 conditions. In this study, we investigated left ventricular dysfunction in patients primarily diagnosed with COPD, and nonreversible airflow limitation in patients primarily diagnosed with CHF. The levels of circulating high-sensitive C-reactive protein (Hs-CRP), pentraxin 3 (PTX3), interleukin-1β (IL-1 β), and soluble type II receptor of IL-1 (sIL-1RII) were also measured as markers of systemic inflammation in these 2 cohorts. Patients aged ≥ 50 years and with ≥ 10 pack years of cigarette smoking who presented with a diagnosis of stable COPD (n=70) or stable CHF (n=124) were recruited. All patients underwent echocardiography, N-terminal pro-hormone of brain natriuretic peptide measurements, and post-bronchodilator spirometry. Plasma levels of Hs-CRP, PTX3, IL-1 β, and sIL-1RII were determined by using a sandwich enzyme-linked immuno-sorbent assay in all patients and in 24 healthy smokers (control subjects). Although we were unable to find a single COPD patient with left ventricular dysfunction, we found nonreversible airflow limitation in 34% of patients with CHF. On the other hand, COPD patients had higher plasma levels of Hs-CRP, IL1 β, and sIL-1RII compared with CHF patients and control subjects (p < 0.05). None of the inflammatory biomarkers was different between CHF patients and control subjects. In conclusion, although the COPD patients had no evidence of CHF, up to one third of patients with CHF had airflow limitation, suggesting that routine spirometry is warranted in patients with CHF, whereas echocardiography is not required in well characterized patients with COPD. Only smokers with COPD seem to have evidence of systemic inflammation.</description><subject>Aged</subject><subject>Air flow</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Brain</subject><subject>Brain natriuretic peptide</subject><subject>Bronchodilators</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Case-Control Studies</subject><subject>Chronic Disease</subject><subject>Chronic illnesses</subject><subject>Chronic obstructive lung disease</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Cigarette smoking</subject><subject>Comorbidity</subject><subject>Coronary artery disease</subject><subject>Cytokines</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Geriatrics</subject><subject>Heart diseases</subject><subject>Heart failure</subject><subject>Heart Failure - blood</subject><subject>Heart Failure - diagnosis</subject><subject>Heart Failure - diagnostic imaging</subject><subject>Heart Failure - physiopathology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunology</subject><subject>Inflammation</subject><subject>Inflammation - blood</subject><subject>Inflammation - diagnosis</subject><subject>Inflammation - diagnostic imaging</subject><subject>Inflammation - physiopathology</subject><subject>Interleukin 1</subject><subject>Interleukin-1beta - blood</subject><subject>Interleukins</subject><subject>Laboratories</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Medical research</subject><subject>Middle Aged</subject><subject>Natriuretic Peptide, Brain - blood</subject><subject>Natriuretic peptides</subject><subject>Observational studies</subject><subject>Obstructive lung disease</subject><subject>Older people</subject><subject>Patients</subject><subject>Pentraxins</subject><subject>Peptide Fragments - blood</subject><subject>Plasma levels</subject><subject>Proteins</subject><subject>Pulmonary Disease, Chronic Obstructive - blood</subject><subject>Pulmonary Disease, Chronic Obstructive - diagnosis</subject><subject>Pulmonary Disease, Chronic Obstructive - diagnostic imaging</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Receptors, Interleukin-1 Type II - blood</subject><subject>Serum Amyloid P-Component - metabolism</subject><subject>Smokers</subject><subject>Smoking</subject><subject>Smoking - physiopathology</subject><subject>Spirometry</subject><subject>Thorax</subject><subject>Ultrasonography</subject><subject>Ventricle</subject><subject>Ventricular Dysfunction, Left - blood</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk99v0zAQxyMEYqPwHyCwhIRAosWOEyfhAWkqG6s0aYhfr9bFdhqXJA62M-gbfzrumk0N2gPyg63z577nO99F0VOCF4Rm5O3GDLaDZtGbTi0wzjFh7F50TAoaz1mM6f2D81H0yLkNxinNGXsYHcVJnCSMFsfRn1NRGwFWarO20NfbN8j12ppWeRvO0Enkts6rVgsEYvBq3tfgFNJd1UDbgjd2i3prvNKdC1bkWvNDWYd-aV-j5eWnD8hYtDw_exe0kCmdslfgtQkvR84Pcvs4elBB49STcZ9F385Ovy7P5xeXH1fLk4u5YEXs58AYYQSLIqnKTEiSpCokwSTkZVKpCseEMJWVEsu0DBslVZkyRhnOQKhUEjqLnu91-8Y4PhbP8SCEQ-VijAOx2hPSwIb3Vrdgt9yA5tcGY9ccrNeiURwrljFaFTJLWJJlAmKQMk9EiXPIYqGC1vsx2lC2SgrVeQvNRHR60-mar80Vp3lM87Bm0atRwJqfg3Ket9oJ1TTQKTNcv7tI0xCeBvTFP-jd2Y3UGkIC4ftMiCt2ovwkyXIak5QVgVrcQYUldx0QOq3SwT5xeD1xCIxXv_0aBuf46svn_2cvv0_ZlwdsraDxtTPNsGsdNwWTPSiscc6q6rbIBPPdoNxUg-8GhY-DEtyeHX7QrdPNZNC_WW4PXg</recordid><startdate>20131111</startdate><enddate>20131111</enddate><creator>Beghé, Bianca</creator><creator>Verduri, Alessia</creator><creator>Bottazzi, Barbara</creator><creator>Stendardo, Mariarita</creator><creator>Fucili, Alessandro</creator><creator>Balduzzi, Sara</creator><creator>Leuzzi, Chiara</creator><creator>Papi, Alberto</creator><creator>Mantovani, Alberto</creator><creator>Fabbri, Leonardo M</creator><creator>Ceconi, Claudio</creator><creator>Boschetto, Piera</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20131111</creationdate><title>Echocardiography, spirometry, and systemic acute-phase inflammatory proteins in smokers with COPD or CHF: an observational study</title><author>Beghé, Bianca ; Verduri, Alessia ; Bottazzi, Barbara ; Stendardo, Mariarita ; Fucili, Alessandro ; Balduzzi, Sara ; Leuzzi, Chiara ; Papi, Alberto ; Mantovani, Alberto ; Fabbri, Leonardo M ; Ceconi, Claudio ; Boschetto, Piera</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-a661610c94fb7cd145e2426da8b4fef02116e7bd0d5b7bd31fb5663607ace5d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Air flow</topic><topic>Biomarkers</topic><topic>Biomarkers - 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metabolism</topic><topic>Smokers</topic><topic>Smoking</topic><topic>Smoking - physiopathology</topic><topic>Spirometry</topic><topic>Thorax</topic><topic>Ultrasonography</topic><topic>Ventricle</topic><topic>Ventricular Dysfunction, Left - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beghé, Bianca</creatorcontrib><creatorcontrib>Verduri, Alessia</creatorcontrib><creatorcontrib>Bottazzi, Barbara</creatorcontrib><creatorcontrib>Stendardo, Mariarita</creatorcontrib><creatorcontrib>Fucili, Alessandro</creatorcontrib><creatorcontrib>Balduzzi, Sara</creatorcontrib><creatorcontrib>Leuzzi, Chiara</creatorcontrib><creatorcontrib>Papi, Alberto</creatorcontrib><creatorcontrib>Mantovani, Alberto</creatorcontrib><creatorcontrib>Fabbri, Leonardo M</creatorcontrib><creatorcontrib>Ceconi, Claudio</creatorcontrib><creatorcontrib>Boschetto, Piera</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beghé, Bianca</au><au>Verduri, Alessia</au><au>Bottazzi, Barbara</au><au>Stendardo, Mariarita</au><au>Fucili, Alessandro</au><au>Balduzzi, Sara</au><au>Leuzzi, Chiara</au><au>Papi, Alberto</au><au>Mantovani, Alberto</au><au>Fabbri, Leonardo M</au><au>Ceconi, Claudio</au><au>Boschetto, Piera</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Echocardiography, spirometry, and systemic acute-phase inflammatory proteins in smokers with COPD or CHF: an observational study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-11-11</date><risdate>2013</risdate><volume>8</volume><issue>11</issue><spage>e80166</spage><epage>e80166</epage><pages>e80166-e80166</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) may coexist in elderly patients with a history of smoking. Low-grade systemic inflammation induced by smoking may represent the link between these 2 conditions. In this study, we investigated left ventricular dysfunction in patients primarily diagnosed with COPD, and nonreversible airflow limitation in patients primarily diagnosed with CHF. The levels of circulating high-sensitive C-reactive protein (Hs-CRP), pentraxin 3 (PTX3), interleukin-1β (IL-1 β), and soluble type II receptor of IL-1 (sIL-1RII) were also measured as markers of systemic inflammation in these 2 cohorts. Patients aged ≥ 50 years and with ≥ 10 pack years of cigarette smoking who presented with a diagnosis of stable COPD (n=70) or stable CHF (n=124) were recruited. All patients underwent echocardiography, N-terminal pro-hormone of brain natriuretic peptide measurements, and post-bronchodilator spirometry. Plasma levels of Hs-CRP, PTX3, IL-1 β, and sIL-1RII were determined by using a sandwich enzyme-linked immuno-sorbent assay in all patients and in 24 healthy smokers (control subjects). Although we were unable to find a single COPD patient with left ventricular dysfunction, we found nonreversible airflow limitation in 34% of patients with CHF. On the other hand, COPD patients had higher plasma levels of Hs-CRP, IL1 β, and sIL-1RII compared with CHF patients and control subjects (p < 0.05). None of the inflammatory biomarkers was different between CHF patients and control subjects. In conclusion, although the COPD patients had no evidence of CHF, up to one third of patients with CHF had airflow limitation, suggesting that routine spirometry is warranted in patients with CHF, whereas echocardiography is not required in well characterized patients with COPD. Only smokers with COPD seem to have evidence of systemic inflammation.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24244639</pmid><doi>10.1371/journal.pone.0080166</doi><tpages>e80166</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-11, Vol.8 (11), p.e80166-e80166 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1450016200 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Aged Air flow Biomarkers Biomarkers - blood Brain Brain natriuretic peptide Bronchodilators C-reactive protein C-Reactive Protein - metabolism Cardiology Cardiovascular disease Case-Control Studies Chronic Disease Chronic illnesses Chronic obstructive lung disease Chronic obstructive pulmonary disease Cigarette smoking Comorbidity Coronary artery disease Cytokines Echocardiography Female Geriatrics Heart diseases Heart failure Heart Failure - blood Heart Failure - diagnosis Heart Failure - diagnostic imaging Heart Failure - physiopathology Hospitals Humans Immunology Inflammation Inflammation - blood Inflammation - diagnosis Inflammation - diagnostic imaging Inflammation - physiopathology Interleukin 1 Interleukin-1beta - blood Interleukins Laboratories Lung diseases Male Medical research Middle Aged Natriuretic Peptide, Brain - blood Natriuretic peptides Observational studies Obstructive lung disease Older people Patients Pentraxins Peptide Fragments - blood Plasma levels Proteins Pulmonary Disease, Chronic Obstructive - blood Pulmonary Disease, Chronic Obstructive - diagnosis Pulmonary Disease, Chronic Obstructive - diagnostic imaging Pulmonary Disease, Chronic Obstructive - physiopathology Receptors, Interleukin-1 Type II - blood Serum Amyloid P-Component - metabolism Smokers Smoking Smoking - physiopathology Spirometry Thorax Ultrasonography Ventricle Ventricular Dysfunction, Left - blood |
| title | Echocardiography, spirometry, and systemic acute-phase inflammatory proteins in smokers with COPD or CHF: an observational study |
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