NF-κB-induced IL-6 ensures STAT3 activation and tumor aggressiveness in glioblastoma

Glioblastoma (GBM) is the most aggressive, neurologically destructive and deadly tumor of the central nervous system (CNS). In GBM, the transcription factors NF-κB and STAT3 are aberrantly activated and associated with tumor cell proliferation, survival, invasion and chemoresistance. In addition, co...

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Veröffentlicht in:	PloS one 2013-11, Vol.8 (11), p.e78728-e78728
Hauptverfasser:	McFarland, Braden C, Hong, Suk W, Rajbhandari, Rajani, Twitty, Jr, George B, Gray, G Kenneth, Yu, Hao, Benveniste, Etty N, Nozell, Susan E
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Biology Biotechnology Brain cancer Brain tumors Cell Line, Tumor Cell proliferation Cell survival Central nervous system Chemoresistance Crosstalk Female Gene expression Gene Expression Regulation, Neoplastic Genomics Glioblastoma Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - pathology Glioblastoma - therapy Glioma Heterografts Humans Immunoglobulins Interleukin 6 Interleukin-6 - biosynthesis Interleukin-6 - genetics Kinases Mice Mice, Nude Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplasm Transplantation NF-kappa B - genetics NF-kappa B - metabolism NF-κB protein Pathways Pharmacology Proteins Signal transduction Signaling Stat3 protein STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Stem cells Survival Transcription factors Tumor necrosis factor-TNF Tumor necrosis factor-α Tumors Xenografts Xenotransplantation
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