MuSK myasthenia gravis IgG4 disrupts the interaction of LRP4 with MuSK but both IgG4 and IgG1-3 can disperse preformed agrin-independent AChR clusters

A variable proportion of patients with generalized myasthenia gravis (MG) have autoantibodies to muscle specific tyrosine kinase (MuSK). During development agrin, released from the motor nerve, interacts with low density lipoprotein receptor-related protein-4 (LRP4), which then binds to MuSK; MuSK i...

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Veröffentlicht in:	PloS one 2013-11, Vol.8 (11), p.e80695-e80695
Hauptverfasser:	Koneczny, Inga, Cossins, Judith, Waters, Patrick, Beeson, David, Vincent, Angela
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Agrin Agrin - metabolism Antibiotics Antibodies Autoantibodies Autoimmunity Binding Child Child, Preschool Clustering Clusters Consent Crosslinking Density Dispersion Endocytosis Fab Female Fragments Hostages Humans Immunoglobulin G Immunoglobulin G - metabolism Immunoglobulins Immunoprecipitation Inhibition LDL-Receptor Related Proteins - metabolism Low density lipoprotein Low density lipoprotein receptors Male Medicine Muscles Myasthenia Myasthenia gravis Myasthenia Gravis - immunology Myasthenia Gravis - metabolism Myotubes Neuromuscular junctions Neurosciences Patients Plasmas (physics) Protein Binding Protein-tyrosine kinase Proteins Receptor density Receptor Protein-Tyrosine Kinases - metabolism Receptors Receptors, Cholinergic - metabolism Synapses Tyrosine Young Adult
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