Metabolic changes in the visual cortex of binocular blindness macaque monkeys: a proton magnetic resonance spectroscopy study
To evaluate proton magnetic resonance spectroscopy ((1)H-MRS) in a study of cross-modal plasticity in the visual cortex of binocular blindness macaque monkeys. Four healthy neonatal macaque monkeys were randomly divided into 2 groups, with 2 in each group. Optic nerve transection was performed in bo...
Gespeichert in:
| Veröffentlicht in: | PloS one 2013-11, Vol.8 (11), p.e80073-e80073 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e80073 |
|---|---|
| container_issue | 11 |
| container_start_page | e80073 |
| container_title | PloS one |
| container_volume | 8 |
| creator | Wu, Lingjie Tang, Zuohua Sun, Xinghuai Feng, Xiaoyuan Qian, Wen Wang, Jie Jin, Lixin |
| description | To evaluate proton magnetic resonance spectroscopy ((1)H-MRS) in a study of cross-modal plasticity in the visual cortex of binocular blindness macaque monkeys.
Four healthy neonatal macaque monkeys were randomly divided into 2 groups, with 2 in each group. Optic nerve transection was performed in both monkeys in the experimental group (group B) to obtain binocular blindness. Two healthy macaque monkeys served as a control group (group A). After sixteen months post-procedure, (1)H-MRS was performed in the visual cortex of all monkeys. We compared the peak areas of NAA, Cr, Cho, Glx and Ins and the ratios of NAA/Cr, Cho/Cr, Glx/Cr and Ins/Cr of each monkey in group B with group A.
The peak area of NAA and the NAA/Cr ratio in the visual cortex of monkey 4 in group B were found to be dramatically decreased, the peak area of NAA slightly decreased and the NAA/Cr ratio clearly decreased in visual cortex of monkey 3 in group B than those in group A. The peak area of Ins and the Ins/Cr ratio in the visual cortex of monkey 4 in group B slightly increased. The peak area of Cho and the Cho/Cr ratio in the visual cortex of all monkeys in group B dramatically increased compared with group A. The peak area of Glx in the visual cortex of all monkeys in group B slightly increased compared with group A.
(1)H-MRS could detect biochemical and metabolic changes in the visual cortex and therefore this technique can be used to provide valuable information for investigating the mechanisms of cross-modal plasticity of binocular blindness in a macaque monkey model. |
| doi_str_mv | 10.1371/journal.pone.0080073 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1448799783</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A478416165</galeid><doaj_id>oai_doaj_org_article_1118f12914f64369953e5eeb53ffe3e2</doaj_id><sourcerecordid>A478416165</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-2960b86fab67b1922d89681c62807eaba6378a5b40f32b1ad16348b1537c65d3</originalsourceid><addsrcrecordid>eNqNk1trFDEUxwdRbK1-A9GAIPqway4zmYwPQileFioFLb6GTObMbmo22SaZ4j743c2607IjfZA8JCS_8z-XnFMUzwmeE1aTd1d-CE7Z-cY7mGMsMK7Zg-KYNIzOOMXs4cH5qHgS4xXGFROcPy6OaElpiVl9XPz-Ckm13hqN9Eq5JURkHEorQDcmDsoi7UOCX8j3qDXO68GqgFprXOcgRrRWWl0PgNbe_YRtfI8U2gSfvMsvSwcpywaI3imnAcUN6BR81H6zRTEN3fZp8ahXNsKzcT8pLj99vDz7Mju_-Lw4Oz2fad7QNKMNx63gvWp53ZKG0k40XBDNqcA1qFZxVgtVtSXuGW2J6ghnpWhJxWrNq46dFC_3shvroxwLFyUpS1E3TS1YJhZ7ovPqSm6CWauwlV4Z-ffCh6VUIWdjQRJCRE9oQ8qel4w3TcWgAmgr1vfAgGatD6O3oV1Dp8GloOxEdPrizEou_Y1kggiGd8G8GQWCz8WNSa5N1GCtcuCHXdyVqDDLYWf01T_o_dmN1FLlBIzrffard6LytKxFSTjhVabm91B5dbA2OndZb_L9xODtxCAzuVXSUg0xysX3b__PXvyYsq8P2BUom1bR2yEZ7-IULPegzl0VA_R3RSZY7obkthpyNyRyHJJs9uLwg-6MbqeC_QEDpw15</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1448799783</pqid></control><display><type>article</type><title>Metabolic changes in the visual cortex of binocular blindness macaque monkeys: a proton magnetic resonance spectroscopy study</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Wu, Lingjie ; Tang, Zuohua ; Sun, Xinghuai ; Feng, Xiaoyuan ; Qian, Wen ; Wang, Jie ; Jin, Lixin</creator><contributor>Tian, Jie</contributor><creatorcontrib>Wu, Lingjie ; Tang, Zuohua ; Sun, Xinghuai ; Feng, Xiaoyuan ; Qian, Wen ; Wang, Jie ; Jin, Lixin ; Tian, Jie</creatorcontrib><description>To evaluate proton magnetic resonance spectroscopy ((1)H-MRS) in a study of cross-modal plasticity in the visual cortex of binocular blindness macaque monkeys.
Four healthy neonatal macaque monkeys were randomly divided into 2 groups, with 2 in each group. Optic nerve transection was performed in both monkeys in the experimental group (group B) to obtain binocular blindness. Two healthy macaque monkeys served as a control group (group A). After sixteen months post-procedure, (1)H-MRS was performed in the visual cortex of all monkeys. We compared the peak areas of NAA, Cr, Cho, Glx and Ins and the ratios of NAA/Cr, Cho/Cr, Glx/Cr and Ins/Cr of each monkey in group B with group A.
The peak area of NAA and the NAA/Cr ratio in the visual cortex of monkey 4 in group B were found to be dramatically decreased, the peak area of NAA slightly decreased and the NAA/Cr ratio clearly decreased in visual cortex of monkey 3 in group B than those in group A. The peak area of Ins and the Ins/Cr ratio in the visual cortex of monkey 4 in group B slightly increased. The peak area of Cho and the Cho/Cr ratio in the visual cortex of all monkeys in group B dramatically increased compared with group A. The peak area of Glx in the visual cortex of all monkeys in group B slightly increased compared with group A.
(1)H-MRS could detect biochemical and metabolic changes in the visual cortex and therefore this technique can be used to provide valuable information for investigating the mechanisms of cross-modal plasticity of binocular blindness in a macaque monkey model.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0080073</identifier><identifier>PMID: 24224037</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Animals, Newborn ; Binocular vision ; Blindness ; Blindness - metabolism ; Change detection ; Comparative analysis ; Cross-modal ; Glutamine ; Macaca ; Magnetic resonance ; Magnetic resonance spectroscopy ; Magnetic Resonance Spectroscopy - methods ; Monkeys ; Monkeys & apes ; Neonates ; Neurosciences ; Nuclear magnetic resonance spectroscopy ; Optic nerve ; Plastic properties ; Plasticity ; Proton magnetic resonance ; Resonance ; Rodents ; Sensory integration ; Spectroscopic analysis ; Spectroscopy ; Studies ; Visual cortex ; Visual Cortex - metabolism ; Visual plasticity</subject><ispartof>PloS one, 2013-11, Vol.8 (11), p.e80073-e80073</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Wu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Wu et al 2013 Wu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-2960b86fab67b1922d89681c62807eaba6378a5b40f32b1ad16348b1537c65d3</citedby><cites>FETCH-LOGICAL-c692t-2960b86fab67b1922d89681c62807eaba6378a5b40f32b1ad16348b1537c65d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818303/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3818303/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24224037$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Tian, Jie</contributor><creatorcontrib>Wu, Lingjie</creatorcontrib><creatorcontrib>Tang, Zuohua</creatorcontrib><creatorcontrib>Sun, Xinghuai</creatorcontrib><creatorcontrib>Feng, Xiaoyuan</creatorcontrib><creatorcontrib>Qian, Wen</creatorcontrib><creatorcontrib>Wang, Jie</creatorcontrib><creatorcontrib>Jin, Lixin</creatorcontrib><title>Metabolic changes in the visual cortex of binocular blindness macaque monkeys: a proton magnetic resonance spectroscopy study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To evaluate proton magnetic resonance spectroscopy ((1)H-MRS) in a study of cross-modal plasticity in the visual cortex of binocular blindness macaque monkeys.
Four healthy neonatal macaque monkeys were randomly divided into 2 groups, with 2 in each group. Optic nerve transection was performed in both monkeys in the experimental group (group B) to obtain binocular blindness. Two healthy macaque monkeys served as a control group (group A). After sixteen months post-procedure, (1)H-MRS was performed in the visual cortex of all monkeys. We compared the peak areas of NAA, Cr, Cho, Glx and Ins and the ratios of NAA/Cr, Cho/Cr, Glx/Cr and Ins/Cr of each monkey in group B with group A.
The peak area of NAA and the NAA/Cr ratio in the visual cortex of monkey 4 in group B were found to be dramatically decreased, the peak area of NAA slightly decreased and the NAA/Cr ratio clearly decreased in visual cortex of monkey 3 in group B than those in group A. The peak area of Ins and the Ins/Cr ratio in the visual cortex of monkey 4 in group B slightly increased. The peak area of Cho and the Cho/Cr ratio in the visual cortex of all monkeys in group B dramatically increased compared with group A. The peak area of Glx in the visual cortex of all monkeys in group B slightly increased compared with group A.
(1)H-MRS could detect biochemical and metabolic changes in the visual cortex and therefore this technique can be used to provide valuable information for investigating the mechanisms of cross-modal plasticity of binocular blindness in a macaque monkey model.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Binocular vision</subject><subject>Blindness</subject><subject>Blindness - metabolism</subject><subject>Change detection</subject><subject>Comparative analysis</subject><subject>Cross-modal</subject><subject>Glutamine</subject><subject>Macaca</subject><subject>Magnetic resonance</subject><subject>Magnetic resonance spectroscopy</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Monkeys</subject><subject>Monkeys & apes</subject><subject>Neonates</subject><subject>Neurosciences</subject><subject>Nuclear magnetic resonance spectroscopy</subject><subject>Optic nerve</subject><subject>Plastic properties</subject><subject>Plasticity</subject><subject>Proton magnetic resonance</subject><subject>Resonance</subject><subject>Rodents</subject><subject>Sensory integration</subject><subject>Spectroscopic analysis</subject><subject>Spectroscopy</subject><subject>Studies</subject><subject>Visual cortex</subject><subject>Visual Cortex - metabolism</subject><subject>Visual plasticity</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1trFDEUxwdRbK1-A9GAIPqway4zmYwPQileFioFLb6GTObMbmo22SaZ4j743c2607IjfZA8JCS_8z-XnFMUzwmeE1aTd1d-CE7Z-cY7mGMsMK7Zg-KYNIzOOMXs4cH5qHgS4xXGFROcPy6OaElpiVl9XPz-Ckm13hqN9Eq5JURkHEorQDcmDsoi7UOCX8j3qDXO68GqgFprXOcgRrRWWl0PgNbe_YRtfI8U2gSfvMsvSwcpywaI3imnAcUN6BR81H6zRTEN3fZp8ahXNsKzcT8pLj99vDz7Mju_-Lw4Oz2fad7QNKMNx63gvWp53ZKG0k40XBDNqcA1qFZxVgtVtSXuGW2J6ghnpWhJxWrNq46dFC_3shvroxwLFyUpS1E3TS1YJhZ7ovPqSm6CWauwlV4Z-ffCh6VUIWdjQRJCRE9oQ8qel4w3TcWgAmgr1vfAgGatD6O3oV1Dp8GloOxEdPrizEou_Y1kggiGd8G8GQWCz8WNSa5N1GCtcuCHXdyVqDDLYWf01T_o_dmN1FLlBIzrffard6LytKxFSTjhVabm91B5dbA2OndZb_L9xODtxCAzuVXSUg0xysX3b__PXvyYsq8P2BUom1bR2yEZ7-IULPegzl0VA_R3RSZY7obkthpyNyRyHJJs9uLwg-6MbqeC_QEDpw15</recordid><startdate>20131105</startdate><enddate>20131105</enddate><creator>Wu, Lingjie</creator><creator>Tang, Zuohua</creator><creator>Sun, Xinghuai</creator><creator>Feng, Xiaoyuan</creator><creator>Qian, Wen</creator><creator>Wang, Jie</creator><creator>Jin, Lixin</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20131105</creationdate><title>Metabolic changes in the visual cortex of binocular blindness macaque monkeys: a proton magnetic resonance spectroscopy study</title><author>Wu, Lingjie ; Tang, Zuohua ; Sun, Xinghuai ; Feng, Xiaoyuan ; Qian, Wen ; Wang, Jie ; Jin, Lixin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-2960b86fab67b1922d89681c62807eaba6378a5b40f32b1ad16348b1537c65d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Binocular vision</topic><topic>Blindness</topic><topic>Blindness - metabolism</topic><topic>Change detection</topic><topic>Comparative analysis</topic><topic>Cross-modal</topic><topic>Glutamine</topic><topic>Macaca</topic><topic>Magnetic resonance</topic><topic>Magnetic resonance spectroscopy</topic><topic>Magnetic Resonance Spectroscopy - methods</topic><topic>Monkeys</topic><topic>Monkeys & apes</topic><topic>Neonates</topic><topic>Neurosciences</topic><topic>Nuclear magnetic resonance spectroscopy</topic><topic>Optic nerve</topic><topic>Plastic properties</topic><topic>Plasticity</topic><topic>Proton magnetic resonance</topic><topic>Resonance</topic><topic>Rodents</topic><topic>Sensory integration</topic><topic>Spectroscopic analysis</topic><topic>Spectroscopy</topic><topic>Studies</topic><topic>Visual cortex</topic><topic>Visual Cortex - metabolism</topic><topic>Visual plasticity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Lingjie</creatorcontrib><creatorcontrib>Tang, Zuohua</creatorcontrib><creatorcontrib>Sun, Xinghuai</creatorcontrib><creatorcontrib>Feng, Xiaoyuan</creatorcontrib><creatorcontrib>Qian, Wen</creatorcontrib><creatorcontrib>Wang, Jie</creatorcontrib><creatorcontrib>Jin, Lixin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Lingjie</au><au>Tang, Zuohua</au><au>Sun, Xinghuai</au><au>Feng, Xiaoyuan</au><au>Qian, Wen</au><au>Wang, Jie</au><au>Jin, Lixin</au><au>Tian, Jie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic changes in the visual cortex of binocular blindness macaque monkeys: a proton magnetic resonance spectroscopy study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-11-05</date><risdate>2013</risdate><volume>8</volume><issue>11</issue><spage>e80073</spage><epage>e80073</epage><pages>e80073-e80073</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To evaluate proton magnetic resonance spectroscopy ((1)H-MRS) in a study of cross-modal plasticity in the visual cortex of binocular blindness macaque monkeys.
Four healthy neonatal macaque monkeys were randomly divided into 2 groups, with 2 in each group. Optic nerve transection was performed in both monkeys in the experimental group (group B) to obtain binocular blindness. Two healthy macaque monkeys served as a control group (group A). After sixteen months post-procedure, (1)H-MRS was performed in the visual cortex of all monkeys. We compared the peak areas of NAA, Cr, Cho, Glx and Ins and the ratios of NAA/Cr, Cho/Cr, Glx/Cr and Ins/Cr of each monkey in group B with group A.
The peak area of NAA and the NAA/Cr ratio in the visual cortex of monkey 4 in group B were found to be dramatically decreased, the peak area of NAA slightly decreased and the NAA/Cr ratio clearly decreased in visual cortex of monkey 3 in group B than those in group A. The peak area of Ins and the Ins/Cr ratio in the visual cortex of monkey 4 in group B slightly increased. The peak area of Cho and the Cho/Cr ratio in the visual cortex of all monkeys in group B dramatically increased compared with group A. The peak area of Glx in the visual cortex of all monkeys in group B slightly increased compared with group A.
(1)H-MRS could detect biochemical and metabolic changes in the visual cortex and therefore this technique can be used to provide valuable information for investigating the mechanisms of cross-modal plasticity of binocular blindness in a macaque monkey model.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24224037</pmid><doi>10.1371/journal.pone.0080073</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-11, Vol.8 (11), p.e80073-e80073 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1448799783 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animals Animals, Newborn Binocular vision Blindness Blindness - metabolism Change detection Comparative analysis Cross-modal Glutamine Macaca Magnetic resonance Magnetic resonance spectroscopy Magnetic Resonance Spectroscopy - methods Monkeys Monkeys & apes Neonates Neurosciences Nuclear magnetic resonance spectroscopy Optic nerve Plastic properties Plasticity Proton magnetic resonance Resonance Rodents Sensory integration Spectroscopic analysis Spectroscopy Studies Visual cortex Visual Cortex - metabolism Visual plasticity |
| title | Metabolic changes in the visual cortex of binocular blindness macaque monkeys: a proton magnetic resonance spectroscopy study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T05%3A23%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Metabolic%20changes%20in%20the%20visual%20cortex%20of%20binocular%20blindness%20macaque%20monkeys:%20a%20proton%20magnetic%20resonance%20spectroscopy%20study&rft.jtitle=PloS%20one&rft.au=Wu,%20Lingjie&rft.date=2013-11-05&rft.volume=8&rft.issue=11&rft.spage=e80073&rft.epage=e80073&rft.pages=e80073-e80073&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0080073&rft_dat=%3Cgale_plos_%3EA478416165%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1448799783&rft_id=info:pmid/24224037&rft_galeid=A478416165&rft_doaj_id=oai_doaj_org_article_1118f12914f64369953e5eeb53ffe3e2&rfr_iscdi=true |