Anaerobic co-culture of mesenchymal stem cells and anaerobic pathogens - a new in vitro model system

Human mesenchymal stem cells (hMSCs) are multipotent by nature and are originally isolated from bone marrow. In light of a future application of hMSCs in the oral cavity, a body compartment with varying oxygen partial pressures and an omnipresence of different bacterial species i.e. periodontitis pa...

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Veröffentlicht in:	PloS one 2013-11, Vol.8 (11), p.e78226-e78226
Hauptverfasser:	Kriebel, Katja, Biedermann, Anne, Kreikemeyer, Bernd, Lang, Hermann
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregatibacter actinomycetemcomitans Aggregatibacter actinomycetemcomitans - pathogenicity Aggregatibacter actinomycetemcomitans - physiology Anaerobic conditions Anaerobiosis Analysis Animal behavior Anoxic conditions B cells Bacteria Bacterial Adhesion Bacterial infections Biotechnology Bone marrow Cell culture Cell Hypoxia Cell Line Cell lines Coculture Techniques Cultivation Cytokines Dentistry Epithelial cells Epithelial Cells - cytology Epithelial Cells - immunology Epithelial Cells - microbiology Fibroblasts Fusobacterium nucleatum Fusobacterium nucleatum - pathogenicity Fusobacterium nucleatum - physiology Gene expression Gingiva - cytology Gingiva - immunology Gingiva - microbiology Humans Hypoxia Immunology In vivo methods and tests Infections Inflammation Inoculum Interleukin 8 Interleukin-8 - biosynthesis Interleukin-8 - secretion Internalization Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - immunology Mesenchymal Stromal Cells - microbiology Mesenchyme Oral cavity Oxygen Pathogenic microorganisms Pathogens Periodontitis Porphyromonas gingivalis Porphyromonas gingivalis - pathogenicity Porphyromonas gingivalis - physiology Species Stem cells Testing equipment
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