Traumatic brain injury precipitates cognitive impairment and extracellular Aβ aggregation in Alzheimer's disease transgenic mice

Traumatic brain injury (TBI) has become a signature wound of the wars in Iraq and Afghanistan. Many American soldiers, even those undiagnosed but likely suffering from mild TBI, display Alzheimer's disease (AD)-like cognitive impairments, suggesting a pathological overlap between TBI and AD. Th...

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Veröffentlicht in:	PloS one 2013-11, Vol.8 (11), p.e78851-e78851
Hauptverfasser:	Tajiri, Naoki, Kellogg, S Leilani, Shimizu, Toru, Arendash, Gary W, Borlongan, Cesar V
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - physiopathology Alzheimer's disease Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Animals Brain Brain Injuries - complications Brain Injuries - physiopathology Chemical precipitation Cognition Disorders - etiology Cognition Disorders - physiopathology Cognitive ability Cortex (parietal) Deposits Disease Models, Animal Extracellular Space - metabolism Head injuries Hippocampus - injuries Hippocampus - metabolism Humans Impairment Maze Learning - physiology Memory - physiology Memory tasks Mice Mice, Inbred C57BL Mice, Inbred Strains Mice, Transgenic Microscopy, Confocal Neurodegenerative diseases Parietal Lobe - injuries Parietal Lobe - metabolism Pathology Precipitates Presenilin 1 Presenilin-1 - genetics Presenilin-1 - metabolism Rodents Spatial analysis Spatial memory Surgery Time Factors Transgenic mice Traumatic brain injury Wounds β-Amyloid
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