Heme oxygenase-1 (HO-1) expression in prostate cancer cells modulates the oxidative response in bone cells

Prostate cancer (PCa) is a leading cause of death among males. It is currently estimated that inflammatory responses are linked to 15-20% of all deaths from cancer worldwide. PCa is dominated by complications arising from metastasis to the bone where the tumor cells interact with the bone microenvir...

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Veröffentlicht in:	PloS one 2013-11, Vol.8 (11), p.e80315-e80315
Hauptverfasser:	Ferrando, Mercedes, Wan, Xinhai, Meiss, Roberto, Yang, Jun, De Siervi, Adriana, Navone, Nora, Vazquez, Elba
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals B cells Biocompatibility Biomedical materials Blotting, Western Bone cancer Bone growth Bone remodeling Bone tumors Cancer Cancer cells Cancer metastasis Cell culture Cell Cycle - drug effects Cell growth Cell Line Cell Line, Tumor Cell migration Cell proliferation Cell Proliferation - drug effects Cells, Cultured Change detection Complications Enzymes Explants Femur Flow Cytometry Forkhead protein Gene expression Heme Heme oxygenase (decyclizing) Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism Hemin Hemin - pharmacology Humans Immunoglobulins Immunohistochemistry Impact analysis Inflammation Laboratories Male Males Metastases Metastasis Mice Mice, SCID Oncology Organ Culture Techniques Osteoblastogenesis Osteoblasts Osteoblasts - drug effects Osteoblasts - metabolism Osteogenesis Oxidative stress Oxygenase Pharmacology Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Rodents Signaling Stem cells Tumor cells Tumors
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