The oxytocin receptor gene (OXTR) in relation to state levels of loneliness in adolescence: evidence for micro-level gene-environment interactions
Previous research has shown that the rs53576 variant of the oxytocin receptor gene (OXTR) is associated with trait levels of loneliness, but results are inconsistent. The aim of the present study is to examine micro-level effects of the OXTR rs53576 variant on state levels of loneliness in early ado...
Gespeichert in:
| Veröffentlicht in: | PloS one 2013-11, Vol.8 (11), p.e77689-e77689 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e77689 |
|---|---|
| container_issue | 11 |
| container_start_page | e77689 |
| container_title | PloS one |
| container_volume | 8 |
| creator | van Roekel, Eeske Verhagen, Maaike Scholte, Ron H J Kleinjan, Marloes Goossens, Luc Engels, Rutger C M E |
| description | Previous research has shown that the rs53576 variant of the oxytocin receptor gene (OXTR) is associated with trait levels of loneliness, but results are inconsistent. The aim of the present study is to examine micro-level effects of the OXTR rs53576 variant on state levels of loneliness in early adolescents. In addition, gene-environment interactions are examined between this OXTR variant and positive and negative perceptions of company. Data were collected in 278 adolescents (58% girls), by means of the Experience Sampling Method (ESM). Sampling periods consisted of six days with nine assessments per day. A relation was found between the OXTR rs53576 variant and state loneliness, in girls only. Girls carrying an A allele had higher levels of state loneliness than girls carrying the GG genotype. In addition, adolescents with an A allele were more affected by negative perceptions of company than GG carriers, on weekend days only. No significant gene-environment interactions were found with positive company. Adolescents carrying an A allele were more susceptible to negative environments during weekend days than GG carriers. Our findings emphasize the importance of operationalizing the phenotype and the environment accurately. |
| doi_str_mv | 10.1371/journal.pone.0077689 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1448416219</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A478425909</galeid><doaj_id>oai_doaj_org_article_627a35e7418843a0a66e9dc66c6f633b</doaj_id><sourcerecordid>A478425909</sourcerecordid><originalsourceid>FETCH-LOGICAL-c593t-bbf874bf41e747228b63c2f7343b29a0ace036fab25f9027d8f92517e162267e3</originalsourceid><addsrcrecordid>eNptUttq2zAYNmNj7bK9wdgMu-kunMmSLNm9GJSyQ6FQGBnsTsjyr1RBkTJJCetr7IknJ25pRtGFxK_v8J-K4m2N5jXh9aeV3wYn7XzjHcwR4py13bPitO4IrhhG5Pmj90nxKsYVQg1pGXtZnGCKMeEYnRZ_F7dQ-j93ySvjygAKNsmHcgkOyrObX4sfH8t93MpkvCuTL2OSCUoLO7Cx9Lq02d8aBzGOSDl4C1GBU3Bews4M46vUWXJtVPDVnreXr8DtTPBuDS5lZoIg1egRXxcvtLQR3kz3rPj59cvi8nt1ffPt6vLiulJNR1LV97rltNe0Bk45xm3PiMKaE0p63EkkFSDCtOxxozuE-dDqDjc1h5phzDiQWfH-oLuxPoqpnVHUlLY0Y3LzZsXVATF4uRKbYNYy3AkvjdgHfFgKGZJRFgTDXJImZ1K3LSXZnTHoBsWYYpoR0metz5Pbtl_DkDuUgrRHosc_ztyKpd8J0ta87mgWOJsEgv-9hZjE2uRGWysd-O2Yd9M2iLYMZeiH_6BPVzehljIXYJz22VeNouKC8pbipkMjav4EKp8B8kTz7LXJ8SMCPRDyuGMMoB9qrJEYN_c-GTFurpg2N9PePe7PA-l-Vck_g1nspQ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1448416219</pqid></control><display><type>article</type><title>The oxytocin receptor gene (OXTR) in relation to state levels of loneliness in adolescence: evidence for micro-level gene-environment interactions</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>van Roekel, Eeske ; Verhagen, Maaike ; Scholte, Ron H J ; Kleinjan, Marloes ; Goossens, Luc ; Engels, Rutger C M E</creator><contributor>Krueger, Frank</contributor><creatorcontrib>van Roekel, Eeske ; Verhagen, Maaike ; Scholte, Ron H J ; Kleinjan, Marloes ; Goossens, Luc ; Engels, Rutger C M E ; Krueger, Frank</creatorcontrib><description>Previous research has shown that the rs53576 variant of the oxytocin receptor gene (OXTR) is associated with trait levels of loneliness, but results are inconsistent. The aim of the present study is to examine micro-level effects of the OXTR rs53576 variant on state levels of loneliness in early adolescents. In addition, gene-environment interactions are examined between this OXTR variant and positive and negative perceptions of company. Data were collected in 278 adolescents (58% girls), by means of the Experience Sampling Method (ESM). Sampling periods consisted of six days with nine assessments per day. A relation was found between the OXTR rs53576 variant and state loneliness, in girls only. Girls carrying an A allele had higher levels of state loneliness than girls carrying the GG genotype. In addition, adolescents with an A allele were more affected by negative perceptions of company than GG carriers, on weekend days only. No significant gene-environment interactions were found with positive company. Adolescents carrying an A allele were more susceptible to negative environments during weekend days than GG carriers. Our findings emphasize the importance of operationalizing the phenotype and the environment accurately.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0077689</identifier><identifier>PMID: 24223720</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescence ; Adolescent ; Adolescents ; Alleles ; Behavior ; Carriers ; Child development ; Environment ; Female ; Gene-Environment Interaction ; Genes ; Genetic aspects ; Genetic Association Studies ; Genotype-environment interactions ; Genotypes ; Girls ; Humans ; Loneliness ; Male ; Oxytocin ; Phenotype ; Phenotypes ; Polymorphism, Single Nucleotide ; Receptors, Oxytocin - genetics ; Risk ; Sampling ; Sampling methods ; Science ; Sex Characteristics ; Social isolation ; Studies ; Teenagers ; Youth</subject><ispartof>PloS one, 2013-11, Vol.8 (11), p.e77689-e77689</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 van Roekel et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 van Roekel et al 2013 van Roekel et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c593t-bbf874bf41e747228b63c2f7343b29a0ace036fab25f9027d8f92517e162267e3</citedby><cites>FETCH-LOGICAL-c593t-bbf874bf41e747228b63c2f7343b29a0ace036fab25f9027d8f92517e162267e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817194/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817194/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24223720$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Krueger, Frank</contributor><creatorcontrib>van Roekel, Eeske</creatorcontrib><creatorcontrib>Verhagen, Maaike</creatorcontrib><creatorcontrib>Scholte, Ron H J</creatorcontrib><creatorcontrib>Kleinjan, Marloes</creatorcontrib><creatorcontrib>Goossens, Luc</creatorcontrib><creatorcontrib>Engels, Rutger C M E</creatorcontrib><title>The oxytocin receptor gene (OXTR) in relation to state levels of loneliness in adolescence: evidence for micro-level gene-environment interactions</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Previous research has shown that the rs53576 variant of the oxytocin receptor gene (OXTR) is associated with trait levels of loneliness, but results are inconsistent. The aim of the present study is to examine micro-level effects of the OXTR rs53576 variant on state levels of loneliness in early adolescents. In addition, gene-environment interactions are examined between this OXTR variant and positive and negative perceptions of company. Data were collected in 278 adolescents (58% girls), by means of the Experience Sampling Method (ESM). Sampling periods consisted of six days with nine assessments per day. A relation was found between the OXTR rs53576 variant and state loneliness, in girls only. Girls carrying an A allele had higher levels of state loneliness than girls carrying the GG genotype. In addition, adolescents with an A allele were more affected by negative perceptions of company than GG carriers, on weekend days only. No significant gene-environment interactions were found with positive company. Adolescents carrying an A allele were more susceptible to negative environments during weekend days than GG carriers. Our findings emphasize the importance of operationalizing the phenotype and the environment accurately.</description><subject>Adolescence</subject><subject>Adolescent</subject><subject>Adolescents</subject><subject>Alleles</subject><subject>Behavior</subject><subject>Carriers</subject><subject>Child development</subject><subject>Environment</subject><subject>Female</subject><subject>Gene-Environment Interaction</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic Association Studies</subject><subject>Genotype-environment interactions</subject><subject>Genotypes</subject><subject>Girls</subject><subject>Humans</subject><subject>Loneliness</subject><subject>Male</subject><subject>Oxytocin</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Receptors, Oxytocin - genetics</subject><subject>Risk</subject><subject>Sampling</subject><subject>Sampling methods</subject><subject>Science</subject><subject>Sex Characteristics</subject><subject>Social isolation</subject><subject>Studies</subject><subject>Teenagers</subject><subject>Youth</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptUttq2zAYNmNj7bK9wdgMu-kunMmSLNm9GJSyQ6FQGBnsTsjyr1RBkTJJCetr7IknJ25pRtGFxK_v8J-K4m2N5jXh9aeV3wYn7XzjHcwR4py13bPitO4IrhhG5Pmj90nxKsYVQg1pGXtZnGCKMeEYnRZ_F7dQ-j93ySvjygAKNsmHcgkOyrObX4sfH8t93MpkvCuTL2OSCUoLO7Cx9Lq02d8aBzGOSDl4C1GBU3Bews4M46vUWXJtVPDVnreXr8DtTPBuDS5lZoIg1egRXxcvtLQR3kz3rPj59cvi8nt1ffPt6vLiulJNR1LV97rltNe0Bk45xm3PiMKaE0p63EkkFSDCtOxxozuE-dDqDjc1h5phzDiQWfH-oLuxPoqpnVHUlLY0Y3LzZsXVATF4uRKbYNYy3AkvjdgHfFgKGZJRFgTDXJImZ1K3LSXZnTHoBsWYYpoR0metz5Pbtl_DkDuUgrRHosc_ztyKpd8J0ta87mgWOJsEgv-9hZjE2uRGWysd-O2Yd9M2iLYMZeiH_6BPVzehljIXYJz22VeNouKC8pbipkMjav4EKp8B8kTz7LXJ8SMCPRDyuGMMoB9qrJEYN_c-GTFurpg2N9PePe7PA-l-Vck_g1nspQ</recordid><startdate>20131104</startdate><enddate>20131104</enddate><creator>van Roekel, Eeske</creator><creator>Verhagen, Maaike</creator><creator>Scholte, Ron H J</creator><creator>Kleinjan, Marloes</creator><creator>Goossens, Luc</creator><creator>Engels, Rutger C M E</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20131104</creationdate><title>The oxytocin receptor gene (OXTR) in relation to state levels of loneliness in adolescence: evidence for micro-level gene-environment interactions</title><author>van Roekel, Eeske ; Verhagen, Maaike ; Scholte, Ron H J ; Kleinjan, Marloes ; Goossens, Luc ; Engels, Rutger C M E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c593t-bbf874bf41e747228b63c2f7343b29a0ace036fab25f9027d8f92517e162267e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescence</topic><topic>Adolescent</topic><topic>Adolescents</topic><topic>Alleles</topic><topic>Behavior</topic><topic>Carriers</topic><topic>Child development</topic><topic>Environment</topic><topic>Female</topic><topic>Gene-Environment Interaction</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic Association Studies</topic><topic>Genotype-environment interactions</topic><topic>Genotypes</topic><topic>Girls</topic><topic>Humans</topic><topic>Loneliness</topic><topic>Male</topic><topic>Oxytocin</topic><topic>Phenotype</topic><topic>Phenotypes</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Receptors, Oxytocin - genetics</topic><topic>Risk</topic><topic>Sampling</topic><topic>Sampling methods</topic><topic>Science</topic><topic>Sex Characteristics</topic><topic>Social isolation</topic><topic>Studies</topic><topic>Teenagers</topic><topic>Youth</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Roekel, Eeske</creatorcontrib><creatorcontrib>Verhagen, Maaike</creatorcontrib><creatorcontrib>Scholte, Ron H J</creatorcontrib><creatorcontrib>Kleinjan, Marloes</creatorcontrib><creatorcontrib>Goossens, Luc</creatorcontrib><creatorcontrib>Engels, Rutger C M E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Roekel, Eeske</au><au>Verhagen, Maaike</au><au>Scholte, Ron H J</au><au>Kleinjan, Marloes</au><au>Goossens, Luc</au><au>Engels, Rutger C M E</au><au>Krueger, Frank</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The oxytocin receptor gene (OXTR) in relation to state levels of loneliness in adolescence: evidence for micro-level gene-environment interactions</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-11-04</date><risdate>2013</risdate><volume>8</volume><issue>11</issue><spage>e77689</spage><epage>e77689</epage><pages>e77689-e77689</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Previous research has shown that the rs53576 variant of the oxytocin receptor gene (OXTR) is associated with trait levels of loneliness, but results are inconsistent. The aim of the present study is to examine micro-level effects of the OXTR rs53576 variant on state levels of loneliness in early adolescents. In addition, gene-environment interactions are examined between this OXTR variant and positive and negative perceptions of company. Data were collected in 278 adolescents (58% girls), by means of the Experience Sampling Method (ESM). Sampling periods consisted of six days with nine assessments per day. A relation was found between the OXTR rs53576 variant and state loneliness, in girls only. Girls carrying an A allele had higher levels of state loneliness than girls carrying the GG genotype. In addition, adolescents with an A allele were more affected by negative perceptions of company than GG carriers, on weekend days only. No significant gene-environment interactions were found with positive company. Adolescents carrying an A allele were more susceptible to negative environments during weekend days than GG carriers. Our findings emphasize the importance of operationalizing the phenotype and the environment accurately.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24223720</pmid><doi>10.1371/journal.pone.0077689</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-11, Vol.8 (11), p.e77689-e77689 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1448416219 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescence Adolescent Adolescents Alleles Behavior Carriers Child development Environment Female Gene-Environment Interaction Genes Genetic aspects Genetic Association Studies Genotype-environment interactions Genotypes Girls Humans Loneliness Male Oxytocin Phenotype Phenotypes Polymorphism, Single Nucleotide Receptors, Oxytocin - genetics Risk Sampling Sampling methods Science Sex Characteristics Social isolation Studies Teenagers Youth |
| title | The oxytocin receptor gene (OXTR) in relation to state levels of loneliness in adolescence: evidence for micro-level gene-environment interactions |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T13%3A18%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20oxytocin%20receptor%20gene%20(OXTR)%20in%20relation%20to%20state%20levels%20of%20loneliness%20in%20adolescence:%20evidence%20for%20micro-level%20gene-environment%20interactions&rft.jtitle=PloS%20one&rft.au=van%20Roekel,%20Eeske&rft.date=2013-11-04&rft.volume=8&rft.issue=11&rft.spage=e77689&rft.epage=e77689&rft.pages=e77689-e77689&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0077689&rft_dat=%3Cgale_plos_%3EA478425909%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1448416219&rft_id=info:pmid/24223720&rft_galeid=A478425909&rft_doaj_id=oai_doaj_org_article_627a35e7418843a0a66e9dc66c6f633b&rfr_iscdi=true |