Prognostic significance of circulating tumor cells in non-small-cell lung cancer patients: a meta-analysis
The prognostic significance of circulating tumor cells (CTCs) detected in patients with non-small-cell lung cancer (NSCLC) is still inconsistent. We aimed to assess the prognostic relevance of CTCs using a meta-analysis. We searched PubMed, Web of Science and EMBASE for relevant studies that assesse...
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| description | The prognostic significance of circulating tumor cells (CTCs) detected in patients with non-small-cell lung cancer (NSCLC) is still inconsistent. We aimed to assess the prognostic relevance of CTCs using a meta-analysis.
We searched PubMed, Web of Science and EMBASE for relevant studies that assessed the prognostic relevance of CTCs in NSCLC. Statistical analyses were conducted to calculate the summary incidence, odds ratio, relative risks (RRs) and 95% confidence intervals (CIs) using fixed or random-effects models according to the heterogeneity of included studies.
A total of 20 studies, comprising 1576 patients, met the inclusion criteria. In identified studies, CTCs were not correlated with histology (adenocarcinoma vs squamous cell carcinoma) (odds ratio [OR] = 0.88; 95% confidence interval [CI]: 0.59-1.33; Z = -0.61; P = 0.545). However, pooled analyses showed that CTCs were associated with lymph node metastasis (OR = 2.06; 95% CI: 1.18-3.62; Z = 2.20; P = 0.027) and tumor stage (OR = 1.95; 95% CI: 1.08-3.54; Z = 2.53; P = 0.011). Moreover, CTCs were significantly associated with shorter overall survival (relative risk [RR] = 2.19; 95% CI: 1.53-3.12; Z = 4.32; P |
| doi_str_mv | 10.1371/journal.pone.0078070 |
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We searched PubMed, Web of Science and EMBASE for relevant studies that assessed the prognostic relevance of CTCs in NSCLC. Statistical analyses were conducted to calculate the summary incidence, odds ratio, relative risks (RRs) and 95% confidence intervals (CIs) using fixed or random-effects models according to the heterogeneity of included studies.
A total of 20 studies, comprising 1576 patients, met the inclusion criteria. In identified studies, CTCs were not correlated with histology (adenocarcinoma vs squamous cell carcinoma) (odds ratio [OR] = 0.88; 95% confidence interval [CI]: 0.59-1.33; Z = -0.61; P = 0.545). However, pooled analyses showed that CTCs were associated with lymph node metastasis (OR = 2.06; 95% CI: 1.18-3.62; Z = 2.20; P = 0.027) and tumor stage (OR = 1.95; 95% CI: 1.08-3.54; Z = 2.53; P = 0.011). Moreover, CTCs were significantly associated with shorter overall survival (relative risk [RR] = 2.19; 95% CI: 1.53-3.12; Z = 4.32; P<0.0001) and progression-free/disease-free survival (RR = 2.14; 95% CI: 1.36-3.38; Z = 3.28; P<0.0001).
The presence of CTCs indicates a poor prognosis in patients with NSCLC. Further well-designed prospective studies are required to explore the clinical applications of CTCs in lung cancer.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0078070</identifier><identifier>PMID: 24223761</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adenocarcinoma ; Analysis ; Cancer ; Cancer metastasis ; Cancer research ; Cancer therapies ; Carcinoma, Non-Small-Cell Lung - mortality ; Carcinoma, Non-Small-Cell Lung - secondary ; Care and treatment ; Confidence intervals ; Correlation analysis ; Disease ; Histology ; Hospitals ; Humans ; Lung cancer ; Lung diseases ; Lung Neoplasms - mortality ; Lung Neoplasms - pathology ; Lungs ; Lymph nodes ; Lymphatic Metastasis ; Lymphatic system ; Medical ethics ; Medical prognosis ; Medicine ; Meta-analysis ; Metastases ; Metastasis ; Neoplasm Staging ; Neoplastic Cells, Circulating - pathology ; Non-small cell lung cancer ; Non-small cell lung carcinoma ; Odds Ratio ; Oncology ; Patients ; Prognosis ; Risk ; Risk assessment ; Squamous cell carcinoma ; Statistical analysis ; Studies ; Survival ; Survival Analysis ; Therapeutic applications ; Tumor cells</subject><ispartof>PloS one, 2013-11, Vol.8 (11), p.e78070-e78070</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Huang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Huang et al 2013 Huang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-2fea3d727b4930dad5ca6dd50afba12d705dcb7f2e26139481f5a3346359dd0e3</citedby><cites>FETCH-LOGICAL-c758t-2fea3d727b4930dad5ca6dd50afba12d705dcb7f2e26139481f5a3346359dd0e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817175/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817175/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24223761$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Pallante, Pierlorenzo</contributor><creatorcontrib>Wang, Jianwei</creatorcontrib><creatorcontrib>Huang, Jianwei</creatorcontrib><creatorcontrib>Wang, Ke</creatorcontrib><creatorcontrib>Xu, Jianjun</creatorcontrib><creatorcontrib>Huang, Jian</creatorcontrib><creatorcontrib>Zhang, Tao</creatorcontrib><title>Prognostic significance of circulating tumor cells in non-small-cell lung cancer patients: a meta-analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The prognostic significance of circulating tumor cells (CTCs) detected in patients with non-small-cell lung cancer (NSCLC) is still inconsistent. We aimed to assess the prognostic relevance of CTCs using a meta-analysis.
We searched PubMed, Web of Science and EMBASE for relevant studies that assessed the prognostic relevance of CTCs in NSCLC. Statistical analyses were conducted to calculate the summary incidence, odds ratio, relative risks (RRs) and 95% confidence intervals (CIs) using fixed or random-effects models according to the heterogeneity of included studies.
A total of 20 studies, comprising 1576 patients, met the inclusion criteria. In identified studies, CTCs were not correlated with histology (adenocarcinoma vs squamous cell carcinoma) (odds ratio [OR] = 0.88; 95% confidence interval [CI]: 0.59-1.33; Z = -0.61; P = 0.545). However, pooled analyses showed that CTCs were associated with lymph node metastasis (OR = 2.06; 95% CI: 1.18-3.62; Z = 2.20; P = 0.027) and tumor stage (OR = 1.95; 95% CI: 1.08-3.54; Z = 2.53; P = 0.011). Moreover, CTCs were significantly associated with shorter overall survival (relative risk [RR] = 2.19; 95% CI: 1.53-3.12; Z = 4.32; P<0.0001) and progression-free/disease-free survival (RR = 2.14; 95% CI: 1.36-3.38; Z = 3.28; P<0.0001).
The presence of CTCs indicates a poor prognosis in patients with NSCLC. Further well-designed prospective studies are required to explore the clinical applications of CTCs in lung cancer.</description><subject>Adenocarcinoma</subject><subject>Analysis</subject><subject>Cancer</subject><subject>Cancer metastasis</subject><subject>Cancer research</subject><subject>Cancer therapies</subject><subject>Carcinoma, Non-Small-Cell Lung - mortality</subject><subject>Carcinoma, Non-Small-Cell Lung - secondary</subject><subject>Care and treatment</subject><subject>Confidence intervals</subject><subject>Correlation analysis</subject><subject>Disease</subject><subject>Histology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Lung cancer</subject><subject>Lung diseases</subject><subject>Lung Neoplasms - mortality</subject><subject>Lung Neoplasms - pathology</subject><subject>Lungs</subject><subject>Lymph nodes</subject><subject>Lymphatic Metastasis</subject><subject>Lymphatic system</subject><subject>Medical ethics</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Meta-analysis</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Neoplasm Staging</subject><subject>Neoplastic Cells, Circulating - pathology</subject><subject>Non-small cell lung cancer</subject><subject>Non-small cell lung carcinoma</subject><subject>Odds Ratio</subject><subject>Oncology</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Risk</subject><subject>Risk assessment</subject><subject>Squamous cell carcinoma</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Survival</subject><subject>Survival Analysis</subject><subject>Therapeutic applications</subject><subject>Tumor cells</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk0tr3DAUhU1padK0_6C0hkJpF55KlmXZXRRC6GMgkNLXVtzRw9EgSxPJLs2_r5xxwrhkUbyQufrOke6xb5Y9x2iFCcPvtn4MDuxq551aIcQaxNCD7Bi3pCzqEpGHB-9H2ZMYtwhR0tT14-yorMqSsBofZ9uvwXfOx8GIPJrOGW0EOKFyr3NhghgtDMZ1-TD2PuRCWRtz43LnXRF7sLaYSrkdE3KjC_kuCZQb4vsc8l4NUEC65XU08Wn2SION6tm8nmQ_P338cfalOL_4vD47PS8Eo81QlFoBkaxkm6olSIKkAmopKQK9AVxKhqgUG6ZLVdaYtFWDNQVCqprQVkqkyEn2cu-7sz7yOabIcVU1FU5pVIlY7wnpYct3wfQQrrkHw28KPnQcQkrEKi4R0pXYUN1AWhUCRIXGTa20FCXUbfL6MJ82bnolRWo9gF2YLnecueSd_81JgxlmNBm8mQ2CvxpVHHhv4pQqOOXH6d60oSi12ST01T_o_d3NVAepAeO0T-eKyZSfVqypSto2OFGre6j0SNUbkf4pbVJ9IXi7ECRmUH-GDsYY-fr7t_9nL34t2dcH7KUCO1xGb8fBeBeXYLUHRfAxBqXvQsaITyNxmwafRoLPI5FkLw4_0J3odgbIX1qdCGA</recordid><startdate>20131104</startdate><enddate>20131104</enddate><creator>Wang, Jianwei</creator><creator>Huang, Jianwei</creator><creator>Wang, Ke</creator><creator>Xu, Jianjun</creator><creator>Huang, Jian</creator><creator>Zhang, Tao</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20131104</creationdate><title>Prognostic significance of circulating tumor cells in non-small-cell lung cancer patients: a meta-analysis</title><author>Wang, Jianwei ; Huang, Jianwei ; Wang, Ke ; Xu, Jianjun ; Huang, Jian ; Zhang, Tao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-2fea3d727b4930dad5ca6dd50afba12d705dcb7f2e26139481f5a3346359dd0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adenocarcinoma</topic><topic>Analysis</topic><topic>Cancer</topic><topic>Cancer metastasis</topic><topic>Cancer research</topic><topic>Cancer therapies</topic><topic>Carcinoma, Non-Small-Cell Lung - mortality</topic><topic>Carcinoma, Non-Small-Cell Lung - secondary</topic><topic>Care and treatment</topic><topic>Confidence intervals</topic><topic>Correlation analysis</topic><topic>Disease</topic><topic>Histology</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Lung cancer</topic><topic>Lung diseases</topic><topic>Lung Neoplasms - mortality</topic><topic>Lung Neoplasms - pathology</topic><topic>Lungs</topic><topic>Lymph nodes</topic><topic>Lymphatic Metastasis</topic><topic>Lymphatic system</topic><topic>Medical ethics</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Meta-analysis</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Neoplasm Staging</topic><topic>Neoplastic Cells, Circulating - pathology</topic><topic>Non-small cell lung cancer</topic><topic>Non-small cell lung carcinoma</topic><topic>Odds Ratio</topic><topic>Oncology</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Risk</topic><topic>Risk assessment</topic><topic>Squamous cell carcinoma</topic><topic>Statistical analysis</topic><topic>Studies</topic><topic>Survival</topic><topic>Survival Analysis</topic><topic>Therapeutic applications</topic><topic>Tumor cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Jianwei</creatorcontrib><creatorcontrib>Huang, Jianwei</creatorcontrib><creatorcontrib>Wang, Ke</creatorcontrib><creatorcontrib>Xu, Jianjun</creatorcontrib><creatorcontrib>Huang, Jian</creatorcontrib><creatorcontrib>Zhang, Tao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Source (ProQuest)</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Database (1962 - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Jianwei</au><au>Huang, Jianwei</au><au>Wang, Ke</au><au>Xu, Jianjun</au><au>Huang, Jian</au><au>Zhang, Tao</au><au>Pallante, Pierlorenzo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic significance of circulating tumor cells in non-small-cell lung cancer patients: a meta-analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-11-04</date><risdate>2013</risdate><volume>8</volume><issue>11</issue><spage>e78070</spage><epage>e78070</epage><pages>e78070-e78070</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The prognostic significance of circulating tumor cells (CTCs) detected in patients with non-small-cell lung cancer (NSCLC) is still inconsistent. We aimed to assess the prognostic relevance of CTCs using a meta-analysis.
We searched PubMed, Web of Science and EMBASE for relevant studies that assessed the prognostic relevance of CTCs in NSCLC. Statistical analyses were conducted to calculate the summary incidence, odds ratio, relative risks (RRs) and 95% confidence intervals (CIs) using fixed or random-effects models according to the heterogeneity of included studies.
A total of 20 studies, comprising 1576 patients, met the inclusion criteria. In identified studies, CTCs were not correlated with histology (adenocarcinoma vs squamous cell carcinoma) (odds ratio [OR] = 0.88; 95% confidence interval [CI]: 0.59-1.33; Z = -0.61; P = 0.545). However, pooled analyses showed that CTCs were associated with lymph node metastasis (OR = 2.06; 95% CI: 1.18-3.62; Z = 2.20; P = 0.027) and tumor stage (OR = 1.95; 95% CI: 1.08-3.54; Z = 2.53; P = 0.011). Moreover, CTCs were significantly associated with shorter overall survival (relative risk [RR] = 2.19; 95% CI: 1.53-3.12; Z = 4.32; P<0.0001) and progression-free/disease-free survival (RR = 2.14; 95% CI: 1.36-3.38; Z = 3.28; P<0.0001).
The presence of CTCs indicates a poor prognosis in patients with NSCLC. Further well-designed prospective studies are required to explore the clinical applications of CTCs in lung cancer.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24223761</pmid><doi>10.1371/journal.pone.0078070</doi><tpages>e78070</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma Analysis Cancer Cancer metastasis Cancer research Cancer therapies Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - secondary Care and treatment Confidence intervals Correlation analysis Disease Histology Hospitals Humans Lung cancer Lung diseases Lung Neoplasms - mortality Lung Neoplasms - pathology Lungs Lymph nodes Lymphatic Metastasis Lymphatic system Medical ethics Medical prognosis Medicine Meta-analysis Metastases Metastasis Neoplasm Staging Neoplastic Cells, Circulating - pathology Non-small cell lung cancer Non-small cell lung carcinoma Odds Ratio Oncology Patients Prognosis Risk Risk assessment Squamous cell carcinoma Statistical analysis Studies Survival Survival Analysis Therapeutic applications Tumor cells |
| title | Prognostic significance of circulating tumor cells in non-small-cell lung cancer patients: a meta-analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T18%3A33%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prognostic%20significance%20of%20circulating%20tumor%20cells%20in%20non-small-cell%20lung%20cancer%20patients:%20a%20meta-analysis&rft.jtitle=PloS%20one&rft.au=Wang,%20Jianwei&rft.date=2013-11-04&rft.volume=8&rft.issue=11&rft.spage=e78070&rft.epage=e78070&rft.pages=e78070-e78070&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0078070&rft_dat=%3Cgale_plos_%3EA478425981%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1448416204&rft_id=info:pmid/24223761&rft_galeid=A478425981&rft_doaj_id=oai_doaj_org_article_d00f4cb5f8af4ce0a05cf186efdc2a69&rfr_iscdi=true |