Impairment of pneumococcal antigen specific isotype-switched Igg memory B-cell immunity in HIV infected Malawian adults

Pneumococcal disease is associated with a particularly high morbidity and mortality amongst adults in HIV endemic countries. Our previous findings implicating a B-cell defect in HIV-infected children from the same population led us to comprehensively characterize B-cell subsets in minimally symptoma...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2013-11, Vol.8 (11), p.e78592-e78592
Hauptverfasser:	Iwajomo, Oluwadamilola H, Finn, Adam, Ogunniyi, Abiodun D, Williams, Neil A, Heyderman, Robert S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adults Antigens Antigens, Bacterial - blood Antigens, Bacterial - immunology Apoptosis B-Lymphocyte Subsets - immunology B-Lymphocyte Subsets - pathology Case-Control Studies CD19 antigen CD27 antigen Cell activation Children Disease susceptibility Drug therapy Enzymes Female HIV HIV - immunology HIV infections HIV Infections - blood HIV Infections - complications HIV Infections - immunology HIV Infections - virology HIV patients Hospitals Human immunodeficiency virus Humans Immune response Immune response (cell-mediated) Immune system Immunity Immunoglobulin Class Switching Immunoglobulin D Immunoglobulin G Immunoglobulin G - blood Immunoglobulin M Immunoglobulin M - blood Immunoglobulins Immunologic Memory Immunological memory Immunology Impairment Infection Infections Infectious diseases Lymphocyte Activation Lymphocyte Depletion Lymphocytes Lymphocytes B Lymphocytes T Malawi Male Medicine Morbidity Mortality Pneumonia, Pneumococcal - blood Pneumonia, Pneumococcal - complications Pneumonia, Pneumococcal - immunology Pneumonia, Pneumococcal - microbiology Proteins Statistical analysis Streptococcus infections Streptococcus pneumoniae Streptococcus pneumoniae - immunology T cell receptors T cells Vaccines
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!