Chemokine receptors CCR6 and CXCR3 are necessary for CD4(+) T cell mediated ocular surface disease in experimental dry eye disease

CD4(+) T cells are essential to pathogenesis of ocular surface disease in dry eye. Two subtypes of CD4(+) T cells, Th1 and Th17 cells, function concurrently in dry eye to mediate disease. This occurs in spite of the cross-regulation of IFN-γ and IL-17A, the prototypical cytokines Th1 and Th17 cells,...

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Veröffentlicht in:	PloS one 2013-11, Vol.8 (11), p.e78508
Hauptverfasser:	Coursey, Terry G, Gandhi, Niral B, Volpe, Eugene A, Pflugfelder, Stephen C, de Paiva, Cintia S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animal models Animal tissues Animals CCR6 protein CD4 antigen Cell Movement Cell surface Chemokine receptors Chemokines Conjunctiva Conjunctiva - immunology Conjunctiva - pathology Cornea Cornea - immunology Cornea - pathology Crohn's disease Crohns disease CXCR3 protein Cytokines Desiccants Disease Models, Animal Epithelial cells Epithelial Cells - immunology Epithelial Cells - pathology Eye Eye diseases Female Goblet Cells - immunology Goblet Cells - pathology Helper cells Immune response Immune system Infiltration Inflammation Interferon-gamma - genetics Interferon-gamma - immunology Interleukin-17 - genetics Interleukin-17 - immunology Ligands Localization Lymph nodes Lymph Nodes - immunology Lymph Nodes - pathology Lymphatic system Lymphocytes Lymphocytes T Matrix metalloproteinase Matrix Metalloproteinases - genetics Matrix Metalloproteinases - immunology Medicine Metalloproteinase Mice Mice, Knockout Pathogenesis Psoriasis Receptors Receptors, CCR6 - deficiency Receptors, CCR6 - genetics Receptors, CCR6 - immunology Receptors, CXCR3 - deficiency Receptors, CXCR3 - genetics Receptors, CXCR3 - immunology Rodents Scopolamine T cell receptors Th1 Cells - immunology Th1 Cells - pathology Th17 Cells - immunology Th17 Cells - pathology Therapeutic applications Xerophthalmia - chemically induced Xerophthalmia - genetics Xerophthalmia - immunology Xerophthalmia - pathology γ-Interferon
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