Role of TRPM7 channels in hyperglycemia-mediated injury of vascular endothelial cells

This study investigated the change of transient receptor potential melastatin 7 (TRPM7) expression by high glucose and its role in hyperglycemia induced injury of vascular endothelial cells. Human umbilical vein endothelial cells (HUVECs) were incubated in the presence or absence of high concentrati...

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Veröffentlicht in:	PloS one 2013-11, Vol.8 (11), p.e79540
Hauptverfasser:	Sun, Huawei, Leng, Tiandong, Zeng, Zhao, Gao, Xiuren, Inoue, Koichi, Xiong, Zhi-Gang
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Blood circulation disorders Butadienes - pharmacology Cardiology Cell Survival - drug effects Channels Complications and side effects Cytotoxicity Development and progression Diabetes Dose-Response Relationship, Drug Endothelial cells Endothelium Experiments Exposure Extracellular signal-regulated kinase Gene expression Gene Expression Regulation - drug effects Gene Silencing Genetic aspects Glucose Glucose - pharmacology Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Human Umbilical Vein Endothelial Cells - pathology Humans Hyperglycemia Hyperglycemia - genetics Hyperglycemia - metabolism Hyperglycemia - pathology Immunofluorescence Immunoglobulins Injuries Kinases MAP Kinase Signaling System - drug effects Medicine mRNA Neurosciences Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type III - metabolism Nitric-oxide synthase Nitriles - pharmacology Oxidative stress Oxygen Phosphatase Physiological aspects Polymerase chain reaction Protein-Serine-Threonine Kinases Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Risk factors RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - genetics Rodents Signal transduction Signaling siRNA Smooth muscle Toxicity Transient receptor potential proteins TRPM Cation Channels - deficiency TRPM Cation Channels - genetics TRPM Cation Channels - metabolism Umbilical vein Western blotting
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