A novel scoring system to measure radiographic abnormalities and related spirometric values in cured pulmonary tuberculosis
Despite chemotherapy, patients with cured pulmonary tuberculosis may result in lung functional impairment. To evaluate a novel scoring system based on the degree of radiographic abnormalities and related spirometric values in patients with cured pulmonary tuberculosis. One hundred and twenty seven p...
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| Veröffentlicht in: | PloS one 2013-11, Vol.8 (11), p.e78926 |
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| creator | Báez-Saldaña, Renata López-Arteaga, Yesenia Bizarrón-Muro, Alma Ferreira-Guerrero, Elizabeth Ferreyra-Reyes, Leticia Delgado-Sánchez, Guadalupe Cruz-Hervert, Luis Pablo Mongua-Rodríguez, Norma García-García, Lourdes |
| description | Despite chemotherapy, patients with cured pulmonary tuberculosis may result in lung functional impairment.
To evaluate a novel scoring system based on the degree of radiographic abnormalities and related spirometric values in patients with cured pulmonary tuberculosis.
One hundred and twenty seven patients with cured pulmonary tuberculosis were prospectively enrolled in a referral hospital specializing in respiratory diseases. Spirometry was performed and the extent of radiographic abnormalities was evaluated twice by each of two readers to generate a novel quantitative score. Scoring reproducibility was analyzed by the intra-class correlation coefficient (ICC) and the Bland-Altman method. Multiple linear regression models were performed to assess the association of the extent of radiographic abnormalities with spirometric values.
The intra-observer agreement for scoring of radiographic abnormalities (SRA) showed an ICC of 0.81 (CI:95%, 0.67-0.95) and 0.78 (CI:95%, 0.65-0.92), for reader 1 and 2, respectively. Inter-observer reproducibility for the first measurement was 0.83 (CI:95%, 0.71-0.95), and for the second measurement was 0.74 (CI:95%, 0.58-0.90). The Bland-Altman analysis of the intra-observer agreement showed a mean bias of 0.87% and -0.55% and an inter-observer agreement of -0.35% and -1.78%, indicating a minor average systematic variability. After adjustment for age, gender, height, smoking status, pack-years of smoking, and degree of dyspnea, the scoring degree of radiographic abnormalities was significantly and negatively associated with absolute and percent predicted values of FVC: -0.07 (CI:95%, -0.01 to -0.04); -2.48 (CI:95%, -3.45 to -1.50); and FEV1 -0.07 (CI:95%, -0.10 to -0.05); -2.92 (CI:95%, -3.87 to -1.97) respectively, in the patients studied.
The extent of radiographic abnormalities, as evaluated through our novel scoring system, was inversely associated with spirometric values, and exhibited good reliability and reproducibility. As intra-observer and inter-observer agreement of the SRA varied from good to excellent, the use of SRA in this setting appears acceptable. |
| doi_str_mv | 10.1371/journal.pone.0078926 |
| format | Article |
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To evaluate a novel scoring system based on the degree of radiographic abnormalities and related spirometric values in patients with cured pulmonary tuberculosis.
One hundred and twenty seven patients with cured pulmonary tuberculosis were prospectively enrolled in a referral hospital specializing in respiratory diseases. Spirometry was performed and the extent of radiographic abnormalities was evaluated twice by each of two readers to generate a novel quantitative score. Scoring reproducibility was analyzed by the intra-class correlation coefficient (ICC) and the Bland-Altman method. Multiple linear regression models were performed to assess the association of the extent of radiographic abnormalities with spirometric values.
The intra-observer agreement for scoring of radiographic abnormalities (SRA) showed an ICC of 0.81 (CI:95%, 0.67-0.95) and 0.78 (CI:95%, 0.65-0.92), for reader 1 and 2, respectively. Inter-observer reproducibility for the first measurement was 0.83 (CI:95%, 0.71-0.95), and for the second measurement was 0.74 (CI:95%, 0.58-0.90). The Bland-Altman analysis of the intra-observer agreement showed a mean bias of 0.87% and -0.55% and an inter-observer agreement of -0.35% and -1.78%, indicating a minor average systematic variability. After adjustment for age, gender, height, smoking status, pack-years of smoking, and degree of dyspnea, the scoring degree of radiographic abnormalities was significantly and negatively associated with absolute and percent predicted values of FVC: -0.07 (CI:95%, -0.01 to -0.04); -2.48 (CI:95%, -3.45 to -1.50); and FEV1 -0.07 (CI:95%, -0.10 to -0.05); -2.92 (CI:95%, -3.87 to -1.97) respectively, in the patients studied.
The extent of radiographic abnormalities, as evaluated through our novel scoring system, was inversely associated with spirometric values, and exhibited good reliability and reproducibility. As intra-observer and inter-observer agreement of the SRA varied from good to excellent, the use of SRA in this setting appears acceptable.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0078926</identifier><identifier>PMID: 24223865</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abnormalities ; Adult ; Cancer ; Care and treatment ; Chemotherapy ; Chronic obstructive pulmonary disease ; Correlation analysis ; Correlation coefficient ; Correlation coefficients ; Diagnosis ; Dyspnea ; Female ; Humans ; Infections ; Linear Models ; Lung - diagnostic imaging ; Lung - drug effects ; Lung - physiopathology ; Lung diseases ; Lungs ; Male ; Medical diagnosis ; Middle Aged ; Observer Variation ; Outcome Assessment, Health Care - methods ; Outcome Assessment, Health Care - statistics & numerical data ; Patients ; Pulmonary tuberculosis ; Radiography - methods ; Regression analysis ; Regression models ; Reproducibility ; Respiration ; Respiratory diseases ; Respiratory Function Tests ; Scoring ; Smoking ; Spirometry ; Spirometry - methods ; Tuberculosis ; Tuberculosis, Pulmonary - diagnostic imaging ; Tuberculosis, Pulmonary - drug therapy ; Tuberculosis, Pulmonary - physiopathology ; Values</subject><ispartof>PloS one, 2013-11, Vol.8 (11), p.e78926</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Báez-Saldaña et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Báez-Saldaña et al 2013 Báez-Saldaña et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-32512d0f22278955c51e06110c57022126aa123034ece9199d8fb390554809863</citedby><cites>FETCH-LOGICAL-c692t-32512d0f22278955c51e06110c57022126aa123034ece9199d8fb390554809863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815252/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815252/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24223865$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Pai, Madhukar</contributor><creatorcontrib>Báez-Saldaña, Renata</creatorcontrib><creatorcontrib>López-Arteaga, Yesenia</creatorcontrib><creatorcontrib>Bizarrón-Muro, Alma</creatorcontrib><creatorcontrib>Ferreira-Guerrero, Elizabeth</creatorcontrib><creatorcontrib>Ferreyra-Reyes, Leticia</creatorcontrib><creatorcontrib>Delgado-Sánchez, Guadalupe</creatorcontrib><creatorcontrib>Cruz-Hervert, Luis Pablo</creatorcontrib><creatorcontrib>Mongua-Rodríguez, Norma</creatorcontrib><creatorcontrib>García-García, Lourdes</creatorcontrib><title>A novel scoring system to measure radiographic abnormalities and related spirometric values in cured pulmonary tuberculosis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Despite chemotherapy, patients with cured pulmonary tuberculosis may result in lung functional impairment.
To evaluate a novel scoring system based on the degree of radiographic abnormalities and related spirometric values in patients with cured pulmonary tuberculosis.
One hundred and twenty seven patients with cured pulmonary tuberculosis were prospectively enrolled in a referral hospital specializing in respiratory diseases. Spirometry was performed and the extent of radiographic abnormalities was evaluated twice by each of two readers to generate a novel quantitative score. Scoring reproducibility was analyzed by the intra-class correlation coefficient (ICC) and the Bland-Altman method. Multiple linear regression models were performed to assess the association of the extent of radiographic abnormalities with spirometric values.
The intra-observer agreement for scoring of radiographic abnormalities (SRA) showed an ICC of 0.81 (CI:95%, 0.67-0.95) and 0.78 (CI:95%, 0.65-0.92), for reader 1 and 2, respectively. Inter-observer reproducibility for the first measurement was 0.83 (CI:95%, 0.71-0.95), and for the second measurement was 0.74 (CI:95%, 0.58-0.90). The Bland-Altman analysis of the intra-observer agreement showed a mean bias of 0.87% and -0.55% and an inter-observer agreement of -0.35% and -1.78%, indicating a minor average systematic variability. After adjustment for age, gender, height, smoking status, pack-years of smoking, and degree of dyspnea, the scoring degree of radiographic abnormalities was significantly and negatively associated with absolute and percent predicted values of FVC: -0.07 (CI:95%, -0.01 to -0.04); -2.48 (CI:95%, -3.45 to -1.50); and FEV1 -0.07 (CI:95%, -0.10 to -0.05); -2.92 (CI:95%, -3.87 to -1.97) respectively, in the patients studied.
The extent of radiographic abnormalities, as evaluated through our novel scoring system, was inversely associated with spirometric values, and exhibited good reliability and reproducibility. As intra-observer and inter-observer agreement of the SRA varied from good to excellent, the use of SRA in this setting appears acceptable.</description><subject>Abnormalities</subject><subject>Adult</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Chemotherapy</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Correlation analysis</subject><subject>Correlation coefficient</subject><subject>Correlation coefficients</subject><subject>Diagnosis</subject><subject>Dyspnea</subject><subject>Female</subject><subject>Humans</subject><subject>Infections</subject><subject>Linear Models</subject><subject>Lung - diagnostic imaging</subject><subject>Lung - drug effects</subject><subject>Lung - physiopathology</subject><subject>Lung diseases</subject><subject>Lungs</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Middle Aged</subject><subject>Observer Variation</subject><subject>Outcome Assessment, Health Care - methods</subject><subject>Outcome Assessment, Health Care - statistics & numerical data</subject><subject>Patients</subject><subject>Pulmonary tuberculosis</subject><subject>Radiography - methods</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Reproducibility</subject><subject>Respiration</subject><subject>Respiratory diseases</subject><subject>Respiratory Function Tests</subject><subject>Scoring</subject><subject>Smoking</subject><subject>Spirometry</subject><subject>Spirometry - methods</subject><subject>Tuberculosis</subject><subject>Tuberculosis, Pulmonary - diagnostic imaging</subject><subject>Tuberculosis, Pulmonary - drug therapy</subject><subject>Tuberculosis, Pulmonary - physiopathology</subject><subject>Values</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1uLUzEQxw-iuGv1G4gGBNGH1lxOzuVFKIuXwsKCt9cwzZm2KTlJN8kpLn550213aWUfJA8JM7_5T2aSKYqXjE6YqNmHtR-CAzvZeIcTSuum5dWj4py1go8rTsXjo_NZ8SzGNaVSNFX1tDjjJef5KM-LP1Pi_BYtidoH45Yk3sSEPUme9AhxCEgCdMYvA2xWRhOYOx96sCYZjARcRwJaSNiRuDHB95hCprZgh-w2juis0JHNYHvvINyQNMwx6MH6aOLz4skCbMQXh31U_Pz86cfF1_Hl1ZfZxfRyrKuWp7HgkvGOLjjnuUgptWRIK8aoljXlnPEKgHFBRYkaW9a2XbOYi5ZKWTa0bSoxKl7vdTc5rTr0LSpWlnXDOWV1JmZ7ovOwVptg-nxX5cGoW4MPSwUhGW1RNVAJwbWYU2DlHKGpmag01hyY1jQ7RsXHQ7Zh3mOn0aUA9kT01OPMSi39VomGSS55Fnh3EAj-Orcxqd5EjdaCQz_s7i0bSbm4Rd_8gz5c3YFaQi7AuIXPefVOVE0zVJZNlX_KqJg8QOXVYW90_mQLk-0nAe9PAjKT8HdawhCjmn3_9v_s1a9T9u0Ru0KwaRW9HZLxLp6C5R7UwccYcHHfZEbVbkbuuqF2M6IOM5LDXh0_0H3Q3VCIv4ZlDKE</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>Báez-Saldaña, 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novel scoring system to measure radiographic abnormalities and related spirometric values in cured pulmonary tuberculosis</title><author>Báez-Saldaña, Renata ; López-Arteaga, Yesenia ; Bizarrón-Muro, Alma ; Ferreira-Guerrero, Elizabeth ; Ferreyra-Reyes, Leticia ; Delgado-Sánchez, Guadalupe ; Cruz-Hervert, Luis Pablo ; Mongua-Rodríguez, Norma ; García-García, Lourdes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-32512d0f22278955c51e06110c57022126aa123034ece9199d8fb390554809863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Abnormalities</topic><topic>Adult</topic><topic>Cancer</topic><topic>Care and treatment</topic><topic>Chemotherapy</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Correlation analysis</topic><topic>Correlation coefficient</topic><topic>Correlation coefficients</topic><topic>Diagnosis</topic><topic>Dyspnea</topic><topic>Female</topic><topic>Humans</topic><topic>Infections</topic><topic>Linear Models</topic><topic>Lung - diagnostic imaging</topic><topic>Lung - drug effects</topic><topic>Lung - physiopathology</topic><topic>Lung diseases</topic><topic>Lungs</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Middle Aged</topic><topic>Observer Variation</topic><topic>Outcome Assessment, Health Care - methods</topic><topic>Outcome Assessment, Health Care - statistics & numerical data</topic><topic>Patients</topic><topic>Pulmonary tuberculosis</topic><topic>Radiography - methods</topic><topic>Regression analysis</topic><topic>Regression models</topic><topic>Reproducibility</topic><topic>Respiration</topic><topic>Respiratory diseases</topic><topic>Respiratory Function Tests</topic><topic>Scoring</topic><topic>Smoking</topic><topic>Spirometry</topic><topic>Spirometry - methods</topic><topic>Tuberculosis</topic><topic>Tuberculosis, Pulmonary - diagnostic imaging</topic><topic>Tuberculosis, Pulmonary - drug therapy</topic><topic>Tuberculosis, Pulmonary - physiopathology</topic><topic>Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Báez-Saldaña, Renata</creatorcontrib><creatorcontrib>López-Arteaga, Yesenia</creatorcontrib><creatorcontrib>Bizarrón-Muro, Alma</creatorcontrib><creatorcontrib>Ferreira-Guerrero, Elizabeth</creatorcontrib><creatorcontrib>Ferreyra-Reyes, Leticia</creatorcontrib><creatorcontrib>Delgado-Sánchez, Guadalupe</creatorcontrib><creatorcontrib>Cruz-Hervert, Luis Pablo</creatorcontrib><creatorcontrib>Mongua-Rodríguez, Norma</creatorcontrib><creatorcontrib>García-García, Lourdes</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE 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Madhukar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A novel scoring system to measure radiographic abnormalities and related spirometric values in cured pulmonary tuberculosis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>8</volume><issue>11</issue><spage>e78926</spage><pages>e78926-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Despite chemotherapy, patients with cured pulmonary tuberculosis may result in lung functional impairment.
To evaluate a novel scoring system based on the degree of radiographic abnormalities and related spirometric values in patients with cured pulmonary tuberculosis.
One hundred and twenty seven patients with cured pulmonary tuberculosis were prospectively enrolled in a referral hospital specializing in respiratory diseases. Spirometry was performed and the extent of radiographic abnormalities was evaluated twice by each of two readers to generate a novel quantitative score. Scoring reproducibility was analyzed by the intra-class correlation coefficient (ICC) and the Bland-Altman method. Multiple linear regression models were performed to assess the association of the extent of radiographic abnormalities with spirometric values.
The intra-observer agreement for scoring of radiographic abnormalities (SRA) showed an ICC of 0.81 (CI:95%, 0.67-0.95) and 0.78 (CI:95%, 0.65-0.92), for reader 1 and 2, respectively. Inter-observer reproducibility for the first measurement was 0.83 (CI:95%, 0.71-0.95), and for the second measurement was 0.74 (CI:95%, 0.58-0.90). The Bland-Altman analysis of the intra-observer agreement showed a mean bias of 0.87% and -0.55% and an inter-observer agreement of -0.35% and -1.78%, indicating a minor average systematic variability. After adjustment for age, gender, height, smoking status, pack-years of smoking, and degree of dyspnea, the scoring degree of radiographic abnormalities was significantly and negatively associated with absolute and percent predicted values of FVC: -0.07 (CI:95%, -0.01 to -0.04); -2.48 (CI:95%, -3.45 to -1.50); and FEV1 -0.07 (CI:95%, -0.10 to -0.05); -2.92 (CI:95%, -3.87 to -1.97) respectively, in the patients studied.
The extent of radiographic abnormalities, as evaluated through our novel scoring system, was inversely associated with spirometric values, and exhibited good reliability and reproducibility. As intra-observer and inter-observer agreement of the SRA varied from good to excellent, the use of SRA in this setting appears acceptable.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24223865</pmid><doi>10.1371/journal.pone.0078926</doi><tpages>e78926</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-11, Vol.8 (11), p.e78926 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1447822017 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Abnormalities Adult Cancer Care and treatment Chemotherapy Chronic obstructive pulmonary disease Correlation analysis Correlation coefficient Correlation coefficients Diagnosis Dyspnea Female Humans Infections Linear Models Lung - diagnostic imaging Lung - drug effects Lung - physiopathology Lung diseases Lungs Male Medical diagnosis Middle Aged Observer Variation Outcome Assessment, Health Care - methods Outcome Assessment, Health Care - statistics & numerical data Patients Pulmonary tuberculosis Radiography - methods Regression analysis Regression models Reproducibility Respiration Respiratory diseases Respiratory Function Tests Scoring Smoking Spirometry Spirometry - methods Tuberculosis Tuberculosis, Pulmonary - diagnostic imaging Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - physiopathology Values |
| title | A novel scoring system to measure radiographic abnormalities and related spirometric values in cured pulmonary tuberculosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T21%3A06%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20novel%20scoring%20system%20to%20measure%20radiographic%20abnormalities%20and%20related%20spirometric%20values%20in%20cured%20pulmonary%20tuberculosis&rft.jtitle=PloS%20one&rft.au=B%C3%A1ez-Salda%C3%B1a,%20Renata&rft.date=2013-11-01&rft.volume=8&rft.issue=11&rft.spage=e78926&rft.pages=e78926-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0078926&rft_dat=%3Cgale_plos_%3EA478448619%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1447822017&rft_id=info:pmid/24223865&rft_galeid=A478448619&rft_doaj_id=oai_doaj_org_article_8a6332c3b0a14bea87136ce72a1cc02c&rfr_iscdi=true |