Monoacylglycerol lipase (MAGL) inhibition attenuates acute lung injury in mice

Endocannabinoid signaling is terminated by enzymatic hydrolysis, a process that, for 2-Arachidonoylglycerol (2-AG), is mediated by monoacylglycerol lipase (MAGL). The piperidine carbamate, 4-nitrophenyl- 4-(dibenzo[d] [1,3]dioxol-5-yl (hydroxy) methyl) piperidine- 1-carboxylate (JZL184), is a drug t...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e77706-e77706
Hauptverfasser:	Costola-de-Souza, Carolina, Ribeiro, Alison, Ferraz-de-Paula, Viviane, Calefi, Atilio Sersun, Aloia, Thiago Pinheiro Arrais, Gimenes-Júnior, João Antonio, de Almeida, Vinicius Izidio, Pinheiro, Milena Lobão, Palermo-Neto, João
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Arachidonoylglycerol Acute Lung Injury - drug therapy Acute Lung Injury - metabolism Alveoli Animal models Animals Arachidonic Acids - metabolism Benzodioxoles - pharmacology Bronchoalveolar Lavage Fluid Bronchus Cannabinoid CB1 receptors Cannabinoid CB2 receptors Capillary Permeability - drug effects Cell Adhesion Molecules - drug effects Cell Adhesion Molecules - metabolism Dermatitis Endocannabinoids - metabolism Experiments Glycerides - metabolism Indoles Inflammation Inflammation - drug therapy Inflammation - metabolism Inhibition Laboratory animals Leukocyte migration Leukocytes Leukocytes - drug effects Leukocytes - metabolism Ligands Lipase Lipopolysaccharides Lungs Male Medical research Mice Mice, Inbred C57BL Monoacylglycerol Lipases - antagonists & inhibitors Monoacylglycerol Lipases - metabolism Neutrophils Pathology Permeability Piperidine Piperidines - pharmacology Polyethylene glycol Pyrazole Receptor, Cannabinoid, CB1 - antagonists & inhibitors Receptor, Cannabinoid, CB1 - metabolism Receptor, Cannabinoid, CB2 - antagonists & inhibitors Receptor, Cannabinoid, CB2 - metabolism Receptors Selectivity Signaling Veterinary colleges Veterinary medicine
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