Proliferation of colorectal cancer is promoted by two signaling transduction expression patterns: ErbB2/ErbB3/AKT and MET/ErbB3/MAPK

One of the recent breakthroughs in cancer research is the identification of activating mutations in various receptor tyrosine kinase(RTK) pathways in many cancers including colorectal cancer(CRC). We hypothesize that, alternative to mutations, overexpression of various oncogenic RTKs may also underp...

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Veröffentlicht in:	PloS one 2013, Vol.8 (10), p.e78086-e78086
Hauptverfasser:	Yao, Yong-Liang, Shao, Jie, Zhang, Chunfu, Wu, Jian-Hong, Zhang, Qing-Hui, Wang, Jian-Jun, Zhu, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation AKT protein c-Met protein Cancer Cancer therapies Cell Line, Tumor Cell Proliferation Cell survival Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Epidermal growth factor ErbB-2 protein ErbB-3 protein Humans Immunohistochemistry Indoles - pharmacology Inhibitors Kinases Laboratories MAP kinase Mutation Pathogenesis Protein-tyrosine kinase receptors Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-met - antagonists & inhibitors Proto-Oncogene Proteins c-met - metabolism Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Receptor, ErbB-3 - genetics Receptor, ErbB-3 - metabolism Signal transduction Signal Transduction - genetics Signal Transduction - physiology Signaling Sulfones - pharmacology Tyrosine
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