Genome-Wide Contribution of Genotype by Environment Interaction to Variation of Diabetes-Related Traits

While genome-wide association studies (GWAS) and candidate gene approaches have identified many genetic variants that contribute to disease risk as main effects, the impact of genotype by environment (GxE) interactions remains rather under-surveyed. To explore the importance of GxE interactions for...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e77442-e77442
Hauptverfasser:	Zheng, Ju-Sheng, Arnett, Donna K, Lee, Yu-Chi, Shen, Jian, Parnell, Laurence D, Smith, Caren E, Richardson, Kris, Li, Duo, Borecki, Ingrid B, Ordovás, José M, Lai, Chao-Qiang, Saez, Maria Eugenia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Carbohydrates diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - ethnology Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - pathology Diet Dietary Carbohydrates - administration & dosage Dietary Fats - administration & dosage Dietary fiber dietary protein Dietary Proteins - administration & dosage Environmental factors Environmental impact European Americans European Continental Ancestry Group fasting Fatty acids Fatty Acids, Omega-6 - administration & dosage Female Gene-Environment Interaction genes Genetic diversity Genetic variance genetic variation Genome, Human Genome-Wide Association Study Genomes Genotype genotype-environment interaction Health risk assessment Health risks Homeostasis Humans Insulin Insulin resistance Insulin Resistance - genetics lifestyle Male Middle Aged Nutrition research omega-6 fatty acids Phenotype phenotypic variation Polymorphism, Single Nucleotide Polyunsaturated fatty acids Quantitative Trait, Heritable risk Risk Factors Single-nucleotide polymorphism United States variance
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