Sex-specific effects of high fat diet on indices of metabolic syndrome in 3xTg-AD mice: implications for Alzheimer's disease

Multiple factors of metabolic syndrome have been implicated in the pathogenesis of Alzheimer's disease (AD), including abdominal obesity, insulin resistance, endocrine dysfunction and dyslipidemia. High fat diet, a common experimental model of obesity and metabolic syndrome, has been shown to a...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e78554-e78554
Hauptverfasser:	Barron, Anna M, Rosario, Emily R, Elteriefi, Reem, Pike, Christian J
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Adiposity Alzheimer Disease - complications Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer Disease - physiopathology Alzheimer's disease Amyloid beta-Peptides - metabolism Androgens Animal models Animals Behavior, Animal Cognitive ability Diet Diet, High-Fat - adverse effects Dyslipidemia Female Gender differences High fat diet Hippocampus Hyperglycemia Hyperinsulinemia Hypogonadism - metabolism Insulin Insulin Resistance Male Males Metabolic syndrome Metabolic Syndrome - complications Metabolic Syndrome - metabolism Mice Mice, Transgenic Neurodegenerative diseases Obesity Obesity - complications Pathogenesis Phosphorylation Rodents Sex Sex Characteristics tau Proteins - metabolism β-Amyloid
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