Sex-specific effects of high fat diet on indices of metabolic syndrome in 3xTg-AD mice: implications for Alzheimer's disease
Multiple factors of metabolic syndrome have been implicated in the pathogenesis of Alzheimer's disease (AD), including abdominal obesity, insulin resistance, endocrine dysfunction and dyslipidemia. High fat diet, a common experimental model of obesity and metabolic syndrome, has been shown to a...
Gespeichert in:
| Veröffentlicht in: | PloS one 2013-10, Vol.8 (10), p.e78554-e78554 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e78554 |
|---|---|
| container_issue | 10 |
| container_start_page | e78554 |
| container_title | PloS one |
| container_volume | 8 |
| creator | Barron, Anna M Rosario, Emily R Elteriefi, Reem Pike, Christian J |
| description | Multiple factors of metabolic syndrome have been implicated in the pathogenesis of Alzheimer's disease (AD), including abdominal obesity, insulin resistance, endocrine dysfunction and dyslipidemia. High fat diet, a common experimental model of obesity and metabolic syndrome, has been shown to accelerate cognitive decline and AD-related neuropathology in animal models. However, sex interacts with the metabolic outcomes of high fat diet and, therefore, may alter neuropathological consequences of dietary manipulations. This study examines the effects of sex and high fat diet on metabolic and AD-related neuropathological outcomes in 3xTg-AD mice. Three month-old male and female 3xTg-AD mice were fed either standard or high fat diets for 4 months. Obesity was observed in all high fat fed mice; however, ectopic fat accumulation, hyperglycemia and hyperinsulinemia were observed only in males. Interestingly, despite the different metabolic outcomes of high fat diet, the neuropathological consequences were similar: both male and female mice maintained under high fat diet exhibited significant worsening in behavioral performance and hippocampal accumulation of β-amyloid protein. Because high fat diet resulted in obesity and increased AD-like pathology in both sexes, these data support a role of obesity-related factors in promoting AD pathogenesis. |
| doi_str_mv | 10.1371/journal.pone.0078554 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_plos_</sourceid><recordid>TN_cdi_plos_journals_1446373694</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_35a84f488a744a46b3c2ec354b03df2d</doaj_id><sourcerecordid>3111158421</sourcerecordid><originalsourceid>FETCH-LOGICAL-c592t-3011d5aeade995b5ff67affd1546b016442bc09a172939edd561c83855b37fe33</originalsourceid><addsrcrecordid>eNptkktv1DAUhSMEog_4BwgssSibDH4n6QJpVF6VKrGgrC3Hvp7xKImDnUEt4sfjmUmrFrGy5fud43uvTlG8InhBWEXeb8I2DrpbjGGABcZVLQR_UhyThtFSUsyePrgfFScpbTAWrJbyeXFEOcWCivq4-PMdbso0gvHOGwTOgZkSCg6t_WqNnJ6Q9TChMCA_WG9gX-th0m3osiDdDjaGHnIVsZvrVbn8iPqMnSPfjxnQkw9DQi5EtOx-r8H3EM9S9kygE7wonjndJXg5n6fFj8-fri--llffvlxeLK9KIxo6lQwTYoUGbaFpRCuck5V2zhLBZYuJ5Jy2BjeaVLRhDVgrJDE1ywtpWeWAsdPizcF37EJS8-KSIpxLVjHZ8ExcHggb9EaN0fc63qqgvdo_hLhSOk7edKCY0DV3vK51xbnOHTBDwTDBW8ysozZ7fZh_27Y9WAPDFHX3yPRxZfBrtQq_FKsJpqLKBu9mgxh-biFNqvfJQNfpAcJ233dTScHkDn37D_r_6fiBMjGkFMHdN0Ow2oXpTqV2YVJzmLLs9cNB7kV36WF_AQvVyIk</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1446373694</pqid></control><display><type>article</type><title>Sex-specific effects of high fat diet on indices of metabolic syndrome in 3xTg-AD mice: implications for Alzheimer's disease</title><source>Public Library of Science (PLoS) Journals Open Access</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Barron, Anna M ; Rosario, Emily R ; Elteriefi, Reem ; Pike, Christian J</creator><contributor>Ginsberg, Stephen D.</contributor><creatorcontrib>Barron, Anna M ; Rosario, Emily R ; Elteriefi, Reem ; Pike, Christian J ; Ginsberg, Stephen D.</creatorcontrib><description>Multiple factors of metabolic syndrome have been implicated in the pathogenesis of Alzheimer's disease (AD), including abdominal obesity, insulin resistance, endocrine dysfunction and dyslipidemia. High fat diet, a common experimental model of obesity and metabolic syndrome, has been shown to accelerate cognitive decline and AD-related neuropathology in animal models. However, sex interacts with the metabolic outcomes of high fat diet and, therefore, may alter neuropathological consequences of dietary manipulations. This study examines the effects of sex and high fat diet on metabolic and AD-related neuropathological outcomes in 3xTg-AD mice. Three month-old male and female 3xTg-AD mice were fed either standard or high fat diets for 4 months. Obesity was observed in all high fat fed mice; however, ectopic fat accumulation, hyperglycemia and hyperinsulinemia were observed only in males. Interestingly, despite the different metabolic outcomes of high fat diet, the neuropathological consequences were similar: both male and female mice maintained under high fat diet exhibited significant worsening in behavioral performance and hippocampal accumulation of β-amyloid protein. Because high fat diet resulted in obesity and increased AD-like pathology in both sexes, these data support a role of obesity-related factors in promoting AD pathogenesis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0078554</identifier><identifier>PMID: 24205258</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Accumulation ; Adiposity ; Alzheimer Disease - complications ; Alzheimer Disease - metabolism ; Alzheimer Disease - pathology ; Alzheimer Disease - physiopathology ; Alzheimer's disease ; Amyloid beta-Peptides - metabolism ; Androgens ; Animal models ; Animals ; Behavior, Animal ; Cognitive ability ; Diet ; Diet, High-Fat - adverse effects ; Dyslipidemia ; Female ; Gender differences ; High fat diet ; Hippocampus ; Hyperglycemia ; Hyperinsulinemia ; Hypogonadism - metabolism ; Insulin ; Insulin Resistance ; Male ; Males ; Metabolic syndrome ; Metabolic Syndrome - complications ; Metabolic Syndrome - metabolism ; Mice ; Mice, Transgenic ; Neurodegenerative diseases ; Obesity ; Obesity - complications ; Pathogenesis ; Phosphorylation ; Rodents ; Sex ; Sex Characteristics ; tau Proteins - metabolism ; β-Amyloid</subject><ispartof>PloS one, 2013-10, Vol.8 (10), p.e78554-e78554</ispartof><rights>2013 Barron et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Barron et al 2013 Barron et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c592t-3011d5aeade995b5ff67affd1546b016442bc09a172939edd561c83855b37fe33</citedby><cites>FETCH-LOGICAL-c592t-3011d5aeade995b5ff67affd1546b016442bc09a172939edd561c83855b37fe33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810257/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810257/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27902,27903,53768,53770,79345,79346</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24205258$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ginsberg, Stephen D.</contributor><creatorcontrib>Barron, Anna M</creatorcontrib><creatorcontrib>Rosario, Emily R</creatorcontrib><creatorcontrib>Elteriefi, Reem</creatorcontrib><creatorcontrib>Pike, Christian J</creatorcontrib><title>Sex-specific effects of high fat diet on indices of metabolic syndrome in 3xTg-AD mice: implications for Alzheimer's disease</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Multiple factors of metabolic syndrome have been implicated in the pathogenesis of Alzheimer's disease (AD), including abdominal obesity, insulin resistance, endocrine dysfunction and dyslipidemia. High fat diet, a common experimental model of obesity and metabolic syndrome, has been shown to accelerate cognitive decline and AD-related neuropathology in animal models. However, sex interacts with the metabolic outcomes of high fat diet and, therefore, may alter neuropathological consequences of dietary manipulations. This study examines the effects of sex and high fat diet on metabolic and AD-related neuropathological outcomes in 3xTg-AD mice. Three month-old male and female 3xTg-AD mice were fed either standard or high fat diets for 4 months. Obesity was observed in all high fat fed mice; however, ectopic fat accumulation, hyperglycemia and hyperinsulinemia were observed only in males. Interestingly, despite the different metabolic outcomes of high fat diet, the neuropathological consequences were similar: both male and female mice maintained under high fat diet exhibited significant worsening in behavioral performance and hippocampal accumulation of β-amyloid protein. Because high fat diet resulted in obesity and increased AD-like pathology in both sexes, these data support a role of obesity-related factors in promoting AD pathogenesis.</description><subject>Accumulation</subject><subject>Adiposity</subject><subject>Alzheimer Disease - complications</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Alzheimer's disease</subject><subject>Amyloid beta-Peptides - metabolism</subject><subject>Androgens</subject><subject>Animal models</subject><subject>Animals</subject><subject>Behavior, Animal</subject><subject>Cognitive ability</subject><subject>Diet</subject><subject>Diet, High-Fat - adverse effects</subject><subject>Dyslipidemia</subject><subject>Female</subject><subject>Gender differences</subject><subject>High fat diet</subject><subject>Hippocampus</subject><subject>Hyperglycemia</subject><subject>Hyperinsulinemia</subject><subject>Hypogonadism - metabolism</subject><subject>Insulin</subject><subject>Insulin Resistance</subject><subject>Male</subject><subject>Males</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - complications</subject><subject>Metabolic Syndrome - metabolism</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Neurodegenerative diseases</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Pathogenesis</subject><subject>Phosphorylation</subject><subject>Rodents</subject><subject>Sex</subject><subject>Sex Characteristics</subject><subject>tau Proteins - metabolism</subject><subject>β-Amyloid</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptkktv1DAUhSMEog_4BwgssSibDH4n6QJpVF6VKrGgrC3Hvp7xKImDnUEt4sfjmUmrFrGy5fud43uvTlG8InhBWEXeb8I2DrpbjGGABcZVLQR_UhyThtFSUsyePrgfFScpbTAWrJbyeXFEOcWCivq4-PMdbso0gvHOGwTOgZkSCg6t_WqNnJ6Q9TChMCA_WG9gX-th0m3osiDdDjaGHnIVsZvrVbn8iPqMnSPfjxnQkw9DQi5EtOx-r8H3EM9S9kygE7wonjndJXg5n6fFj8-fri--llffvlxeLK9KIxo6lQwTYoUGbaFpRCuck5V2zhLBZYuJ5Jy2BjeaVLRhDVgrJDE1ywtpWeWAsdPizcF37EJS8-KSIpxLVjHZ8ExcHggb9EaN0fc63qqgvdo_hLhSOk7edKCY0DV3vK51xbnOHTBDwTDBW8ysozZ7fZh_27Y9WAPDFHX3yPRxZfBrtQq_FKsJpqLKBu9mgxh-biFNqvfJQNfpAcJ233dTScHkDn37D_r_6fiBMjGkFMHdN0Ow2oXpTqV2YVJzmLLs9cNB7kV36WF_AQvVyIk</recordid><startdate>20131028</startdate><enddate>20131028</enddate><creator>Barron, Anna M</creator><creator>Rosario, Emily R</creator><creator>Elteriefi, Reem</creator><creator>Pike, Christian J</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20131028</creationdate><title>Sex-specific effects of high fat diet on indices of metabolic syndrome in 3xTg-AD mice: implications for Alzheimer's disease</title><author>Barron, Anna M ; Rosario, Emily R ; Elteriefi, Reem ; Pike, Christian J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c592t-3011d5aeade995b5ff67affd1546b016442bc09a172939edd561c83855b37fe33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Accumulation</topic><topic>Adiposity</topic><topic>Alzheimer Disease - complications</topic><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer Disease - physiopathology</topic><topic>Alzheimer's disease</topic><topic>Amyloid beta-Peptides - metabolism</topic><topic>Androgens</topic><topic>Animal models</topic><topic>Animals</topic><topic>Behavior, Animal</topic><topic>Cognitive ability</topic><topic>Diet</topic><topic>Diet, High-Fat - adverse effects</topic><topic>Dyslipidemia</topic><topic>Female</topic><topic>Gender differences</topic><topic>High fat diet</topic><topic>Hippocampus</topic><topic>Hyperglycemia</topic><topic>Hyperinsulinemia</topic><topic>Hypogonadism - metabolism</topic><topic>Insulin</topic><topic>Insulin Resistance</topic><topic>Male</topic><topic>Males</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - complications</topic><topic>Metabolic Syndrome - metabolism</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Neurodegenerative diseases</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Pathogenesis</topic><topic>Phosphorylation</topic><topic>Rodents</topic><topic>Sex</topic><topic>Sex Characteristics</topic><topic>tau Proteins - metabolism</topic><topic>β-Amyloid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barron, Anna M</creatorcontrib><creatorcontrib>Rosario, Emily R</creatorcontrib><creatorcontrib>Elteriefi, Reem</creatorcontrib><creatorcontrib>Pike, Christian J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barron, Anna M</au><au>Rosario, Emily R</au><au>Elteriefi, Reem</au><au>Pike, Christian J</au><au>Ginsberg, Stephen D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex-specific effects of high fat diet on indices of metabolic syndrome in 3xTg-AD mice: implications for Alzheimer's disease</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-10-28</date><risdate>2013</risdate><volume>8</volume><issue>10</issue><spage>e78554</spage><epage>e78554</epage><pages>e78554-e78554</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Multiple factors of metabolic syndrome have been implicated in the pathogenesis of Alzheimer's disease (AD), including abdominal obesity, insulin resistance, endocrine dysfunction and dyslipidemia. High fat diet, a common experimental model of obesity and metabolic syndrome, has been shown to accelerate cognitive decline and AD-related neuropathology in animal models. However, sex interacts with the metabolic outcomes of high fat diet and, therefore, may alter neuropathological consequences of dietary manipulations. This study examines the effects of sex and high fat diet on metabolic and AD-related neuropathological outcomes in 3xTg-AD mice. Three month-old male and female 3xTg-AD mice were fed either standard or high fat diets for 4 months. Obesity was observed in all high fat fed mice; however, ectopic fat accumulation, hyperglycemia and hyperinsulinemia were observed only in males. Interestingly, despite the different metabolic outcomes of high fat diet, the neuropathological consequences were similar: both male and female mice maintained under high fat diet exhibited significant worsening in behavioral performance and hippocampal accumulation of β-amyloid protein. Because high fat diet resulted in obesity and increased AD-like pathology in both sexes, these data support a role of obesity-related factors in promoting AD pathogenesis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24205258</pmid><doi>10.1371/journal.pone.0078554</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-10, Vol.8 (10), p.e78554-e78554 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1446373694 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Accumulation Adiposity Alzheimer Disease - complications Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer Disease - physiopathology Alzheimer's disease Amyloid beta-Peptides - metabolism Androgens Animal models Animals Behavior, Animal Cognitive ability Diet Diet, High-Fat - adverse effects Dyslipidemia Female Gender differences High fat diet Hippocampus Hyperglycemia Hyperinsulinemia Hypogonadism - metabolism Insulin Insulin Resistance Male Males Metabolic syndrome Metabolic Syndrome - complications Metabolic Syndrome - metabolism Mice Mice, Transgenic Neurodegenerative diseases Obesity Obesity - complications Pathogenesis Phosphorylation Rodents Sex Sex Characteristics tau Proteins - metabolism β-Amyloid |
| title | Sex-specific effects of high fat diet on indices of metabolic syndrome in 3xTg-AD mice: implications for Alzheimer's disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T09%3A10%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sex-specific%20effects%20of%20high%20fat%20diet%20on%20indices%20of%20metabolic%20syndrome%20in%203xTg-AD%20mice:%20implications%20for%20Alzheimer's%20disease&rft.jtitle=PloS%20one&rft.au=Barron,%20Anna%20M&rft.date=2013-10-28&rft.volume=8&rft.issue=10&rft.spage=e78554&rft.epage=e78554&rft.pages=e78554-e78554&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0078554&rft_dat=%3Cproquest_plos_%3E3111158421%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1446373694&rft_id=info:pmid/24205258&rft_doaj_id=oai_doaj_org_article_35a84f488a744a46b3c2ec354b03df2d&rfr_iscdi=true |