Alcohol consumption, one-carbon metabolites, liver cancer and liver disease mortality
Excess alcohol consumption adversely affects one-carbon metabolism and increases the risk of liver disease and liver cancer. Conversely, higher folate levels have been inversely associated with liver damage. The current study investigated the effects of alcohol and one-carbon metabolite intake on li...
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| creator | Schwartz, Lauren M Persson, E Christina Weinstein, Stephanie J Graubard, Barry I Freedman, Neal D Männistö, Satu Albanes, Demetrius McGlynn, Katherine A |
| description | Excess alcohol consumption adversely affects one-carbon metabolism and increases the risk of liver disease and liver cancer. Conversely, higher folate levels have been inversely associated with liver damage. The current study investigated the effects of alcohol and one-carbon metabolite intake on liver cancer incidence and liver disease mortality within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study.
Cox proportional hazards modeling was used to calculate hazard ratios and 95% confidence intervals (CIs) in a population of 27,086 Finnish males with 194 incident liver cancers and 213 liver disease deaths. In a nested case-control subset (95 liver cancers, 103 controls), logistic regression was used to calculate odds ratios and 95% CIs for serum one-carbon metabolites in relation to liver cancer risk.
Daily alcohol consumption of more than 20.44 g was associated with an increased risk of both liver cancer incidence (Hazard Ratio (HR) 1.52, 95%CI 1.06-2.18) and liver disease mortality (HR 6.68, 95%CI 4.16-10.71). These risks were unaffected by one-carbon metabolite intake. Similarly, in the case-control study, none of the serum one-carbon metabolites were associated with liver cancer.
The current study provided no convincing evidence for a protective association of one-carbon metabolite intake or serum level on the risk of liver cancer or liver disease mortality. |
| doi_str_mv | 10.1371/journal.pone.0078156 |
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Cox proportional hazards modeling was used to calculate hazard ratios and 95% confidence intervals (CIs) in a population of 27,086 Finnish males with 194 incident liver cancers and 213 liver disease deaths. In a nested case-control subset (95 liver cancers, 103 controls), logistic regression was used to calculate odds ratios and 95% CIs for serum one-carbon metabolites in relation to liver cancer risk.
Daily alcohol consumption of more than 20.44 g was associated with an increased risk of both liver cancer incidence (Hazard Ratio (HR) 1.52, 95%CI 1.06-2.18) and liver disease mortality (HR 6.68, 95%CI 4.16-10.71). These risks were unaffected by one-carbon metabolite intake. Similarly, in the case-control study, none of the serum one-carbon metabolites were associated with liver cancer.
The current study provided no convincing evidence for a protective association of one-carbon metabolite intake or serum level on the risk of liver cancer or liver disease mortality.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0078156</identifier><identifier>PMID: 24205137</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Alcohol Drinking - adverse effects ; Alcohol Drinking - metabolism ; Alcohol use ; Alcoholic beverages ; Cancer ; Carbon ; Carbon - blood ; Carbon - metabolism ; Carotene ; Confidence intervals ; Disease control ; Disease prevention ; Folic acid ; Hazards ; Health hazards ; Health risk assessment ; Health risks ; Humans ; Incidence ; Liver ; Liver cancer ; Liver diseases ; Liver Diseases - blood ; Liver Diseases - metabolism ; Liver Diseases - mortality ; Liver Neoplasms - blood ; Liver Neoplasms - metabolism ; Liver Neoplasms - mortality ; Males ; Metabolism ; Metabolites ; Mortality ; Proportional Hazards Models ; Risk ; Risk Factors ; Statistical analysis ; Surveys and Questionnaires ; Tocopherol</subject><ispartof>PloS one, 2013-10, Vol.8 (10), p.e78156-e78156</ispartof><rights>2013. This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-b6ed88a1e0084760043c1ccb123cd94da702327348233d28b227e2ed135e05373</citedby><cites>FETCH-LOGICAL-c526t-b6ed88a1e0084760043c1ccb123cd94da702327348233d28b227e2ed135e05373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810254/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810254/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2106,2932,23875,27933,27934,53800,53802</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24205137$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Villa, Erica</contributor><creatorcontrib>Schwartz, Lauren M</creatorcontrib><creatorcontrib>Persson, E Christina</creatorcontrib><creatorcontrib>Weinstein, Stephanie J</creatorcontrib><creatorcontrib>Graubard, Barry I</creatorcontrib><creatorcontrib>Freedman, Neal D</creatorcontrib><creatorcontrib>Männistö, Satu</creatorcontrib><creatorcontrib>Albanes, Demetrius</creatorcontrib><creatorcontrib>McGlynn, Katherine A</creatorcontrib><title>Alcohol consumption, one-carbon metabolites, liver cancer and liver disease mortality</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Excess alcohol consumption adversely affects one-carbon metabolism and increases the risk of liver disease and liver cancer. Conversely, higher folate levels have been inversely associated with liver damage. The current study investigated the effects of alcohol and one-carbon metabolite intake on liver cancer incidence and liver disease mortality within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study.
Cox proportional hazards modeling was used to calculate hazard ratios and 95% confidence intervals (CIs) in a population of 27,086 Finnish males with 194 incident liver cancers and 213 liver disease deaths. In a nested case-control subset (95 liver cancers, 103 controls), logistic regression was used to calculate odds ratios and 95% CIs for serum one-carbon metabolites in relation to liver cancer risk.
Daily alcohol consumption of more than 20.44 g was associated with an increased risk of both liver cancer incidence (Hazard Ratio (HR) 1.52, 95%CI 1.06-2.18) and liver disease mortality (HR 6.68, 95%CI 4.16-10.71). These risks were unaffected by one-carbon metabolite intake. Similarly, in the case-control study, none of the serum one-carbon metabolites were associated with liver cancer.
The current study provided no convincing evidence for a protective association of one-carbon metabolite intake or serum level on the risk of liver cancer or liver disease mortality.</description><subject>Alcohol Drinking - adverse effects</subject><subject>Alcohol Drinking - metabolism</subject><subject>Alcohol use</subject><subject>Alcoholic beverages</subject><subject>Cancer</subject><subject>Carbon</subject><subject>Carbon - blood</subject><subject>Carbon - metabolism</subject><subject>Carotene</subject><subject>Confidence intervals</subject><subject>Disease control</subject><subject>Disease prevention</subject><subject>Folic acid</subject><subject>Hazards</subject><subject>Health hazards</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Humans</subject><subject>Incidence</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Liver diseases</subject><subject>Liver Diseases - blood</subject><subject>Liver Diseases - metabolism</subject><subject>Liver Diseases - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schwartz, Lauren M</au><au>Persson, E Christina</au><au>Weinstein, Stephanie J</au><au>Graubard, Barry I</au><au>Freedman, Neal D</au><au>Männistö, Satu</au><au>Albanes, Demetrius</au><au>McGlynn, Katherine A</au><au>Villa, Erica</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alcohol consumption, one-carbon metabolites, liver cancer and liver disease mortality</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-10-28</date><risdate>2013</risdate><volume>8</volume><issue>10</issue><spage>e78156</spage><epage>e78156</epage><pages>e78156-e78156</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Excess alcohol consumption adversely affects one-carbon metabolism and increases the risk of liver disease and liver cancer. Conversely, higher folate levels have been inversely associated with liver damage. The current study investigated the effects of alcohol and one-carbon metabolite intake on liver cancer incidence and liver disease mortality within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study.
Cox proportional hazards modeling was used to calculate hazard ratios and 95% confidence intervals (CIs) in a population of 27,086 Finnish males with 194 incident liver cancers and 213 liver disease deaths. In a nested case-control subset (95 liver cancers, 103 controls), logistic regression was used to calculate odds ratios and 95% CIs for serum one-carbon metabolites in relation to liver cancer risk.
Daily alcohol consumption of more than 20.44 g was associated with an increased risk of both liver cancer incidence (Hazard Ratio (HR) 1.52, 95%CI 1.06-2.18) and liver disease mortality (HR 6.68, 95%CI 4.16-10.71). These risks were unaffected by one-carbon metabolite intake. Similarly, in the case-control study, none of the serum one-carbon metabolites were associated with liver cancer.
The current study provided no convincing evidence for a protective association of one-carbon metabolite intake or serum level on the risk of liver cancer or liver disease mortality.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24205137</pmid><doi>10.1371/journal.pone.0078156</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Alcohol Drinking - adverse effects Alcohol Drinking - metabolism Alcohol use Alcoholic beverages Cancer Carbon Carbon - blood Carbon - metabolism Carotene Confidence intervals Disease control Disease prevention Folic acid Hazards Health hazards Health risk assessment Health risks Humans Incidence Liver Liver cancer Liver diseases Liver Diseases - blood Liver Diseases - metabolism Liver Diseases - mortality Liver Neoplasms - blood Liver Neoplasms - metabolism Liver Neoplasms - mortality Males Metabolism Metabolites Mortality Proportional Hazards Models Risk Risk Factors Statistical analysis Surveys and Questionnaires Tocopherol |
| title | Alcohol consumption, one-carbon metabolites, liver cancer and liver disease mortality |
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