Prevalence of antibiotic resistance genes and bacterial community composition in a river influenced by a wastewater treatment plant
Antibiotic resistance represents a global health problem, requiring better understanding of the ecology of antibiotic resistance genes (ARGs), their selection and their spread in the environment. Antibiotics are constantly released to the environment through wastewater treatment plant (WWTP) effluen...
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| Veröffentlicht in: | PloS one 2013-10, Vol.8 (10), p.e78906 |
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| description | Antibiotic resistance represents a global health problem, requiring better understanding of the ecology of antibiotic resistance genes (ARGs), their selection and their spread in the environment. Antibiotics are constantly released to the environment through wastewater treatment plant (WWTP) effluents. We investigated, therefore, the effect of these discharges on the prevalence of ARGs and bacterial community composition in biofilm and sediment samples of a receiving river. We used culture-independent approaches such as quantitative PCR to determine the prevalence of eleven ARGs and 16S rRNA gene-based pyrosequencing to examine the composition of bacterial communities. Concentration of antibiotics in WWTP influent and effluent were also determined. ARGs such as qnrS, bla TEM, bla CTX-M, bla SHV, erm(B), sul(I), sul(II), tet(O) and tet(W) were detected in all biofilm and sediment samples analyzed. Moreover, we observed a significant increase in the relative abundance of ARGs in biofilm samples collected downstream of the WWTP discharge. We also found significant differences with respect to community structure and composition between upstream and downstream samples. Therefore, our results indicate that WWTP discharges may contribute to the spread of ARGs into the environment and may also impact on the bacterial communities of the receiving river. |
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Antibiotics are constantly released to the environment through wastewater treatment plant (WWTP) effluents. We investigated, therefore, the effect of these discharges on the prevalence of ARGs and bacterial community composition in biofilm and sediment samples of a receiving river. We used culture-independent approaches such as quantitative PCR to determine the prevalence of eleven ARGs and 16S rRNA gene-based pyrosequencing to examine the composition of bacterial communities. Concentration of antibiotics in WWTP influent and effluent were also determined. ARGs such as qnrS, bla TEM, bla CTX-M, bla SHV, erm(B), sul(I), sul(II), tet(O) and tet(W) were detected in all biofilm and sediment samples analyzed. Moreover, we observed a significant increase in the relative abundance of ARGs in biofilm samples collected downstream of the WWTP discharge. We also found significant differences with respect to community structure and composition between upstream and downstream samples. Therefore, our results indicate that WWTP discharges may contribute to the spread of ARGs into the environment and may also impact on the bacterial communities of the receiving river.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0078906</identifier><identifier>PMID: 24205347</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aeromonas ; Anti-Bacterial Agents - analysis ; Antibiotic resistance ; Antibiotics ; Bacteria ; Bacteria - classification ; Bacteria - genetics ; Bacteria - isolation & purification ; Biofilms ; Chromatography ; Community composition ; Community structure ; Discharge ; Drug resistance ; Drug Resistance, Microbial - genetics ; Ecology ; Effluents ; Environmental impact ; Fluvial sediments ; Genes ; Genes, Bacterial ; Global health ; Laboratories ; Mass spectrometry ; Microorganisms ; Nosocomial infections ; Plasmids ; Relative abundance ; Rivers ; Rivers - microbiology ; rRNA 16S ; Scientific imaging ; Sediments ; Trends ; Waste Management ; Waste Water - chemistry ; Waste Water - microbiology ; Wastewater disposal ; Wastewater treatment ; Wastewater treatment plants ; Water treatment</subject><ispartof>PloS one, 2013-10, Vol.8 (10), p.e78906</ispartof><rights>2013 Marti et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Antibiotics are constantly released to the environment through wastewater treatment plant (WWTP) effluents. We investigated, therefore, the effect of these discharges on the prevalence of ARGs and bacterial community composition in biofilm and sediment samples of a receiving river. We used culture-independent approaches such as quantitative PCR to determine the prevalence of eleven ARGs and 16S rRNA gene-based pyrosequencing to examine the composition of bacterial communities. Concentration of antibiotics in WWTP influent and effluent were also determined. ARGs such as qnrS, bla TEM, bla CTX-M, bla SHV, erm(B), sul(I), sul(II), tet(O) and tet(W) were detected in all biofilm and sediment samples analyzed. Moreover, we observed a significant increase in the relative abundance of ARGs in biofilm samples collected downstream of the WWTP discharge. We also found significant differences with respect to community structure and composition between upstream and downstream samples. Therefore, our results indicate that WWTP discharges may contribute to the spread of ARGs into the environment and may also impact on the bacterial communities of the receiving river.</description><subject>Aeromonas</subject><subject>Anti-Bacterial Agents - analysis</subject><subject>Antibiotic resistance</subject><subject>Antibiotics</subject><subject>Bacteria</subject><subject>Bacteria - classification</subject><subject>Bacteria - genetics</subject><subject>Bacteria - isolation & purification</subject><subject>Biofilms</subject><subject>Chromatography</subject><subject>Community composition</subject><subject>Community structure</subject><subject>Discharge</subject><subject>Drug resistance</subject><subject>Drug Resistance, Microbial - genetics</subject><subject>Ecology</subject><subject>Effluents</subject><subject>Environmental impact</subject><subject>Fluvial sediments</subject><subject>Genes</subject><subject>Genes, Bacterial</subject><subject>Global health</subject><subject>Laboratories</subject><subject>Mass spectrometry</subject><subject>Microorganisms</subject><subject>Nosocomial infections</subject><subject>Plasmids</subject><subject>Relative abundance</subject><subject>Rivers</subject><subject>Rivers - 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Antibiotics are constantly released to the environment through wastewater treatment plant (WWTP) effluents. We investigated, therefore, the effect of these discharges on the prevalence of ARGs and bacterial community composition in biofilm and sediment samples of a receiving river. We used culture-independent approaches such as quantitative PCR to determine the prevalence of eleven ARGs and 16S rRNA gene-based pyrosequencing to examine the composition of bacterial communities. Concentration of antibiotics in WWTP influent and effluent were also determined. ARGs such as qnrS, bla TEM, bla CTX-M, bla SHV, erm(B), sul(I), sul(II), tet(O) and tet(W) were detected in all biofilm and sediment samples analyzed. Moreover, we observed a significant increase in the relative abundance of ARGs in biofilm samples collected downstream of the WWTP discharge. We also found significant differences with respect to community structure and composition between upstream and downstream samples. Therefore, our results indicate that WWTP discharges may contribute to the spread of ARGs into the environment and may also impact on the bacterial communities of the receiving river.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24205347</pmid><doi>10.1371/journal.pone.0078906</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Aeromonas Anti-Bacterial Agents - analysis Antibiotic resistance Antibiotics Bacteria Bacteria - classification Bacteria - genetics Bacteria - isolation & purification Biofilms Chromatography Community composition Community structure Discharge Drug resistance Drug Resistance, Microbial - genetics Ecology Effluents Environmental impact Fluvial sediments Genes Genes, Bacterial Global health Laboratories Mass spectrometry Microorganisms Nosocomial infections Plasmids Relative abundance Rivers Rivers - microbiology rRNA 16S Scientific imaging Sediments Trends Waste Management Waste Water - chemistry Waste Water - microbiology Wastewater disposal Wastewater treatment Wastewater treatment plants Water treatment |
| title | Prevalence of antibiotic resistance genes and bacterial community composition in a river influenced by a wastewater treatment plant |
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