New oral anticoagulants are not superior to warfarin in secondary prevention of stroke or transient ischemic attacks, but lower the risk of intracranial bleeding: insights from a meta-analysis and indirect treatment comparisons

Patients with Atrial Fibrillation (AF) and prior stroke are classified as high risk in all risk stratification schemes. A systematic review and meta-analysis was performed to compare the efficacy and safety of New Oral Anticoagulants (NOACs) to warfarin in patients with AF and previous stroke or tra...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e77694-e77694
Hauptverfasser:	Sardar, Partha, Chatterjee, Saurav, Wu, Wen-Chih, Lichstein, Edgar, Ghosh, Joydeep, Aikat, Shamik, Mukherjee, Debabrata
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Aged Anticoagulants Anticoagulants - therapeutic use Bleeding Cardiac arrhythmia Cerebrovascular system Clinical trials Confidence intervals Effectiveness Female Fibrillation Hemorrhage - prevention & control Humans Intracranial Hemorrhages - prevention & control Ischemia Ischemic Attack, Transient - drug therapy Ischemic Attack, Transient - prevention & control Maimonides (Moses ben Maimon) (1135-1204) Male Meta-analysis Middle Aged Patients Prevention Randomization Randomized Controlled Trials as Topic Risk Safety Secondary Prevention - methods Stroke Stroke - drug therapy Stroke - prevention & control Systematic review Transient ischemic attack Warfarin Warfarin - therapeutic use
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